Aliases for LRRFIP1 Gene
External Ids for LRRFIP1 Gene
Previous GeneCards Identifiers for LRRFIP1 Gene
GeneCards Summary for LRRFIP1 Gene
LRRFIP1 (LRR Binding FLII Interacting Protein 1) is a Protein Coding gene. Diseases associated with LRRFIP1 include Marasmus. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and double-stranded RNA binding. An important paralog of this gene is LRRFIP2.
UniProtKB/Swiss-Prot Summary for LRRFIP1 Gene
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.