Aliases for LRRFIP1 Gene
Aliases for LRRFIP1 Gene
External Ids for LRRFIP1 Gene
- HGNC: 6702
- Entrez Gene: 9208
- Ensembl: ENSG00000124831
- OMIM: 603256
- UniProtKB: Q32MZ4
Previous GeneCards Identifiers for LRRFIP1 Gene
- GC02P236649
- GC02P237282
- GC02P238617
- GC02P238823
- GC02P238887
- GC02P238382
- GC02P238265
- GC02P230392
- GC02P238536
Summaries for LRRFIP1 Gene
GeneCards Summary for LRRFIP1 Gene
LRRFIP1 (LRR Binding FLII Interacting Protein 1) is a Protein Coding gene. Diseases associated with LRRFIP1 include Gingival Recession. Among its related pathways are HIV Life Cycle and FGFR1 mutant receptor activation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and double-stranded RNA binding. An important paralog of this gene is LRRFIP2.
UniProtKB/Swiss-Prot for LRRFIP1 Gene
-
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5-AGCCCCCGGCG-3) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Additional gene information for LRRFIP1 Gene
- Monarch Initiative
- Search for LRRFIP1 at DataMed
- Search for LRRFIP1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRFIP1 Gene
Genomics for LRRFIP1 Gene
GeneHancer (GH) Regulatory Elements for LRRFIP1 Gene
Promoters and enhancers for LRRFIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around LRRFIP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LRRFIP1 gene promoter:
-
- HNF-4alpha1
- HNF-4alpha2
- GR-alpha
- GR
- Max1
- COUP-TF
- COUP-TF1
- COUP
Regulatory Element Products
Genomic Locations for LRRFIP1 Gene
Genomic Locations for LRRFIP1 Gene
- chr2:237,627,576-237,813,682
- (GRCh38/hg38)
- Size:
- 186,107 bases
- Orientation:
- Plus strand
- chr2:238,536,219-238,722,325
- (GRCh37/hg19)
- Size:
- 186,107 bases
- Orientation:
- Plus strand
Genomic View for LRRFIP1 Gene
Genes around LRRFIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by Entrez Gene
- 2q37.3 by HGNC
- 2q37.3 by Ensembl
LRRFIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LRRFIP1 Gene
Proteins for LRRFIP1 Gene
-
Protein details for LRRFIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q32MZ4-LRRF1_HUMAN
- Recommended name:
- Leucine-rich repeat flightless-interacting protein 1
- Protein Accession:
- Q32MZ4
- E9PGZ2
- O75766
- O75799
- Q32MZ5
- Q53T49
- Q6PKG2
- Q9Y607
Protein attributes for LRRFIP1 Gene
- Size:
- 808 amino acids
- Molecular mass:
- 89253 Da
- Quaternary structure:
-
- Homodimer. May also form higher oligomers. Interacts with FLII. Interacts with MYD88. Competes with FLII for MyD88-binding, even in the absence of LPS.
- SequenceCaution:
-
- Sequence=AAH01385.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAY14672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for LRRFIP1 Gene
Post-translational modifications for LRRFIP1 Gene
Other Protein References for LRRFIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LRRFIP1
-
Abcam antibodies for LRRFIP1
- Invitrogen Antibodies for LRRFIP1 (AFLGC-LRRFIP1)
- GeneTex LRRFIP1 Antibody for LRRFIP1
-
Boster Bio Antibodies for LRRFIP1
-
Custom Antibody ServicesProSci Antibodies for LRRFIP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for LRRFIP1
Protein Products
-
OriGene Purified Proteins for LRRFIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for LRRFIP1
- Origene Custom Protein Services for LRRFIP1
- Search GeneTex for Proteins for LRRFIP1
-
Abcam proteins for LRRFIP1
Assay Products
- antibodies-online: Search results for 4 available TRIP Elisa Kits ranked by validation data
- Compare Top TRIP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for LRRFIP1 Gene
Domains & Families for LRRFIP1 Gene
Gene Families for LRRFIP1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Suggested Antigen Peptide Sequences for LRRFIP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q32MZ4UniProtKB/Swiss-Prot:
LRRF1_HUMAN :- The DNA-binding domain is intrinsically unstructured.
- Belongs to the LRRFIP family.
- Domain:
-
- The DNA-binding domain is intrinsically unstructured.
- The coiled coil mediates dimerization.
- Family:
-
- Belongs to the LRRFIP family.
Function for LRRFIP1 Gene
Molecular function for LRRFIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5-AGCCCCCGGCG-3) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
- GENATLAS Biochemistry:
- leucine rich repeat in FLII-interacting protein 1,identical to the TAR RNA interacting protein,with specific alternatively spliced transcripts,mainly expressed in heart and skeletal muscle
Phenotypes From GWAS Catalog for LRRFIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 14522076 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 14522076 |
| GO:0003677 | DNA binding | IDA,IEA | 23099021 |
| GO:0003725 | double-stranded RNA binding | TAS | 9671805 |
Phenotypes for LRRFIP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LRRFIP1
-
CRISPR Products
-
OriGene CRISPR knockouts for LRRFIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRRFIP1
- genomics-online: gRNA clones - Search results for available TRIP gene related products
- Applied Biological Materials CRISPR for LRRFIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRFIP1
- GenScript: Design CRISPR guide RNA sequences for LRRFIP1
miRNA for LRRFIP1 Gene
- miRTarBase miRNAs that target LRRFIP1
-
- hsa-mir-21-5p (MIRT001220)
- hsa-mir-30a-5p (MIRT005182)
- hsa-mir-215-5p (MIRT024762)
- hsa-mir-34a-5p (MIRT025366)
- hsa-mir-192-5p (MIRT026309)
- hsa-mir-877-3p (MIRT037048)
- hsa-mir-877-5p (MIRT037289)
- hsa-mir-186-5p (MIRT045105)
- hsa-mir-149-5p (MIRT045426)
- hsa-mir-218-5p (MIRT440307)
- hsa-mir-7152-5p (MIRT648095)
- hsa-mir-3074-5p (MIRT648096)
- hsa-mir-6868-3p (MIRT648097)
- hsa-mir-6780a-3p (MIRT648098)
- hsa-mir-6881-3p (MIRT648099)
- hsa-mir-7111-3p (MIRT648100)
- hsa-mir-7162-5p (MIRT648101)
- hsa-mir-516b-3p (MIRT648102)
- hsa-mir-516a-3p (MIRT648103)
- hsa-mir-3124-3p (MIRT648104)
- hsa-mir-130b-5p (MIRT648105)
- hsa-mir-3667-3p (MIRT648106)
- hsa-mir-6734-3p (MIRT648107)
- hsa-mir-1266-3p (MIRT648108)
- hsa-mir-4267 (MIRT648109)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRRFIP1
- Browse OriGene Inhibitory RNA Products For LRRFIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRFIP1
- genomics-online: shRNA clones - Search results for available TRIP gene related products
Clone Products
-
OriGene ORF clones in human for LRRFIP1
- RC216265
- RC216265L1
- RC216265L2
- RC216265L3
- RC216265L4
- RC226522
- RC226522L1
- RC226522L2
- RC226522L3
- RC226522L4
- RC226542
- RC226542L1
- RC226542L2
- RC226542L3
- RC226542L4
- RC226574
- RC226574L1
- RC226574L2
- RC226574L3
- RC226574L4
- RC227988
- RC227988L1
- RC227988L2
- RC227988L3
- RC227988L4
- RG216265
- RG226522
- RG226542
- RG226574
- RG227988
- RC216265L1V
- RC216265L2V
- RC216265L3V
- RC216265L4V
- RC226522L1V
- RC226522L2V
- RC226522L3V
- RC226522L4V
- RC226542L1V
- RC226542L2V
- RC226542L3V
- RC226542L4V
- RC226574L1V
- RC226574L2V
- RC226574L3V
- RC226574L4V
- RC227988L1V
- RC227988L2V
- RC227988L3V
- RC227988L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LRRFIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRRFIP1
- genomics-online: cdna clones - Search results for available TRIP gene related products
- orf clones - Search results for available TRIP gene related products
- Applied Biological Materials Clones for LRRFIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LRRFIP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRFIP1 Gene
Localization for LRRFIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LRRFIP1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS,TAS | 9705290 |
| GO:0005737 | cytoplasm | TAS | 9671805 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | TAS | 9671805 |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for LRRFIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FGFR1 mutant receptor activation | ||
| 2 | Cytosolic sensors of pathogen-associated DNA | ||
| 3 | HIV Life Cycle |
.45
|
|
| 4 | Innate Immune System |
.61
|
|
| 5 | Signaling by FGFR2 in disease | ||
Pathways by source for LRRFIP1 Gene
10 Reactome pathways for LRRFIP1 Gene
Interacting Proteins for LRRFIP1 Gene
Selected Interacting proteins:
ENSP00000375857
Q32MZ4-LRRF1_HUMAN
for LRRFIP1 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for LRRFIP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 14522076 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 9705290 |
| GO:0032481 | positive regulation of type I interferon production | TAS | -- |
No data available for SIGNOR curated interactions for LRRFIP1 Gene
Transcripts for LRRFIP1 Gene
mRNA/cDNA for LRRFIP1 Gene
- (17) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (513) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000308482 2775 bps (uc002vxc.4)
- ENST00000465870 1626 bps (uc061ubc.1)
- ENST00000489295 364 bps (uc061ubd.1)
- ENST00000498053 593 bps (uc061ube.1)
- ENST00000289175 3709 bps (uc002vxf.4)
Unigene Clusters for LRRFIP1 Gene
- Leucine rich repeat (in FLII) interacting protein 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LRRFIP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRRFIP1
- genomics-online: gRNA clones - Search results for available TRIP gene related products
- Applied Biological Materials CRISPR for LRRFIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRFIP1
- GenScript: Design CRISPR guide RNA sequences for LRRFIP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRRFIP1
- Browse OriGene Inhibitory RNA Products For LRRFIP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRFIP1
- genomics-online: shRNA clones - Search results for available TRIP gene related products
Clone Products
-
OriGene ORF clones in human for LRRFIP1
- RC216265
- RC216265L1
- RC216265L2
- RC216265L3
- RC216265L4
- RC226522
- RC226522L1
- RC226522L2
- RC226522L3
- RC226522L4
- RC226542
- RC226542L1
- RC226542L2
- RC226542L3
- RC226542L4
- RC226574
- RC226574L1
- RC226574L2
- RC226574L3
- RC226574L4
- RC227988
- RC227988L1
- RC227988L2
- RC227988L3
- RC227988L4
- RG216265
- RG226522
- RG226542
- RG226574
- RG227988
- RC216265L1V
- RC216265L2V
- RC216265L3V
- RC216265L4V
- RC226522L1V
- RC226522L2V
- RC226522L3V
- RC226522L4V
- RC226542L1V
- RC226542L2V
- RC226542L3V
- RC226542L4V
- RC226574L1V
- RC226574L2V
- RC226574L3V
- RC226574L4V
- RC227988L1V
- RC227988L2V
- RC227988L3V
- RC227988L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LRRFIP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRRFIP1
- genomics-online: cdna clones - Search results for available TRIP gene related products
- orf clones - Search results for available TRIP gene related products
- Applied Biological Materials Clones for LRRFIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | - | ||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | - | ||||||||
| SP12: | |||||||||
| SP13: | - | ||||||||
| SP14: |
Expression for LRRFIP1 Gene
This gene is overexpressed in Nasal epithelium (19.0), Peripheral blood mononuclear cells (9.3), and Lymph node (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRFIP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of LRRFIP1 Gene:
LRRFIP1SOURCE GeneReport for Unigene cluster for LRRFIP1 Gene:
Hs.471779mRNA Expression by UniProt/SwissProt for LRRFIP1 Gene:
Q32MZ4-LRRF1_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for LRRFIP1 Gene
- Liver(4.4)
- Heart(4.3)
- Lung(3.4)
- Skin(3)
- Muscle(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for LRRFIP1
- genomics-online: primer clones - Search results for available TRIP gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRFIP1 Gene
Orthologs for LRRFIP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | LRRFIP1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LRRFIP1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Lrrfip1 16 34 33 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LRRFIP1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LRRFIP1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | LRRFIP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LRRFIP1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | LRRFIP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lrrfip1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15436 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lrrfip1b 34 33 |
|
OneToMany | |
| lrrfip1a 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8578 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | flap-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5234 34 |
|
OneToMany |
- Species where no ortholog for LRRFIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for LRRFIP1 Gene
- ENSEMBL:
- Gene Tree for LRRFIP1 (if available)
- TreeFam:
- Gene Tree for LRRFIP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LRRFIP1: view image
Paralogs for LRRFIP1 Gene
Variants for LRRFIP1 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036037 | A breast cancer sample | p.Ser68Cys | |||
| rs1000030698 | -- | 237,749,804(+) | A/G | intron_variant | |
| rs1000056249 | -- | 237,752,387(+) | C/G | intron_variant | |
| rs1000061402 | -- | 237,703,292(+) | C/T | intron_variant | |
| rs1000063739 | -- | 237,642,383(+) | G/A/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1221e212 | CNV | loss | 25503493 |
| dgv2181n106 | CNV | deletion | 24896259 |
| dgv7345n54 | CNV | loss | 21841781 |
| dgv7346n54 | CNV | loss | 21841781 |
| dgv7347n54 | CNV | loss | 21841781 |
| esv1004389 | CNV | deletion | 20482838 |
| esv23602 | CNV | loss | 19812545 |
| esv24426 | CNV | loss | 19812545 |
| esv2660099 | CNV | deletion | 23128226 |
| esv2664469 | CNV | deletion | 23128226 |
| esv2721737 | CNV | deletion | 23290073 |
| esv2721738 | CNV | deletion | 23290073 |
| esv3561236 | CNV | deletion | 23714750 |
| esv3594748 | CNV | loss | 21293372 |
| esv4182 | CNV | loss | 18987735 |
| esv997081 | CNV | insertion | 20482838 |
| nsv1000252 | CNV | loss | 25217958 |
| nsv1010093 | CNV | gain | 25217958 |
| nsv1073026 | CNV | deletion | 25765185 |
| nsv1122022 | CNV | deletion | 24896259 |
| nsv3230 | CNV | insertion | 18451855 |
| nsv507077 | OTHER | sequence alteration | 20534489 |
| nsv508893 | CNV | insertion | 20534489 |
| nsv518573 | CNV | gain | 19592680 |
| nsv519961 | CNV | loss | 19592680 |
| nsv584746 | CNV | loss | 21841781 |
| nsv584752 | CNV | loss | 21841781 |
| nsv584753 | CNV | loss | 21841781 |
| nsv963784 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.41;
77.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LRRFIP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRFIP1 Gene
Disorders for LRRFIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gingival recession |
|
|
Search LRRFIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LRRFIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LRRFIP1 Gene
Publications for LRRFIP1 Gene
- GCF2/LRRFIP1 represses tumor necrosis factor alpha expression. (PMID: 16199883) Suriano AR … Sullivan KE (Molecular and cellular biology 2005) 2 3 4 58
- GCF2: expression and molecular analysis of repression. (PMID: 14522076) Rikiyama T … Johnson AC (Biochimica et biophysica acta 2003) 3 4 22 58
- Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. (PMID: 10366446) Fong KS … de Couet HG (Genomics 1999) 3 4 22 58
- Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor. (PMID: 9705290) Reed AL … Johnson AC (The Journal of biological chemistry 1998) 2 3 4 58
- Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. (PMID: 23099021) Nguyen JB … Modis Y (Journal of structural biology 2013) 3 4 58
Products for LRRFIP1 Gene
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Sources for LRRFIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (26) UniGene
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- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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