Aliases for LRRD1 Gene

Aliases for LRRD1 Gene

  • Leucine Rich Repeats And Death Domain Containing 1 2 3 5
  • Leucine-Rich Repeat And Death Domain-Containing Protein 1 3 4
  • Leucine-Rich Repeat And Death Domain-Containing Protein LOC401387 3
  • IMAGE:4798971 2
  • LRRD1 5

External Ids for LRRD1 Gene

Previous GeneCards Identifiers for LRRD1 Gene

  • GC07M091743
  • GC07M092113

Summaries for LRRD1 Gene

GeneCards Summary for LRRD1 Gene

LRRD1 (Leucine Rich Repeats And Death Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MFHAS1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRD1 Gene

Genomics for LRRD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRD1

Genomic Locations for LRRD1 Gene

Latest Assembly
chr7:92,141,643-92,179,531
(GRCh38/hg38)
Size:
37,889 bases
Orientation:
Minus strand

Previous Assembly
chr7:91,770,957-91,808,456
(GRCh37/hg19 by Entrez Gene)
Size:
37,500 bases
Orientation:
Minus strand

chr7:91,741,473-91,808,845
(GRCh37/hg19 by Ensembl)
Size:
67,373 bases
Orientation:
Minus strand

Genomic View for LRRD1 Gene

Genes around LRRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRD1 Gene

Proteins for LRRD1 Gene

  • Protein details for LRRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1F6-LRRD1_HUMAN
    Recommended name:
    Leucine-rich repeat and death domain-containing protein 1
    Protein Accession:
    A4D1F6
    Secondary Accessions:
    • B7ZMM9
    • Q49AT9

    Protein attributes for LRRD1 Gene

    Size:
    860 amino acids
    Molecular mass:
    98035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAL24153.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRD1 Gene

Post-translational modifications for LRRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRD1 Gene

No data available for DME Specific Peptides for LRRD1 Gene

Domains & Families for LRRD1 Gene

Gene Families for LRRD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRD1 Gene

Suggested Antigen Peptide Sequences for LRRD1 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat and death domain-containing protein 1 (LRRD1_HUMAN)
genes like me logo Genes that share domains with LRRD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRD1 Gene

Function for LRRD1 Gene

Phenotypes From GWAS Catalog for LRRD1 Gene

Gene Ontology (GO) - Molecular Function for LRRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRD1: view

Phenotypes for LRRD1 Gene

genes like me logo Genes that share phenotypes with LRRD1: view

miRNA for LRRD1 Gene

miRTarBase miRNAs that target LRRD1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRD1 Gene

Localization for LRRD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRD1 gene
Compartment Confidence
cytosol 2
plasma membrane 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRD1 Gene

Pathways & Interactions for LRRD1 Gene

PathCards logo

SuperPathways for LRRD1 Gene

No Data Available

Interacting Proteins for LRRD1 Gene

Gene Ontology (GO) - Biological Process for LRRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
GO:0046579 positive regulation of Ras protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with LRRD1: view

No data available for Pathways by source and SIGNOR curated interactions for LRRD1 Gene

Drugs & Compounds for LRRD1 Gene

No Compound Related Data Available

Transcripts for LRRD1 Gene

mRNA/cDNA for LRRD1 Gene

5 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRD1

Alternative Splicing Database (ASD) splice patterns (SP) for LRRD1 Gene

No ASD Table

Relevant External Links for LRRD1 Gene

GeneLoc Exon Structure for
LRRD1

Expression for LRRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRD1 Gene

mRNA differential expression in normal tissues according to GTEx for LRRD1 Gene

This gene is overexpressed in Testis (x33.0).

Protein differential expression in normal tissues from HIPED for LRRD1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRD1 Gene



Protein tissue co-expression partners for LRRD1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRD1

SOURCE GeneReport for Unigene cluster for LRRD1 Gene:

Hs.671729

Evidence on tissue expression from TISSUES for LRRD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LRRD1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRD1 Gene

Orthologs for LRRD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRD1 29 30
  • 99.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRD1 29 30
  • 87.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRD1 29 30
  • 86.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrrd1 29 16 30
  • 77.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrd1 29
  • 76.86 (n)
Oppossum
(Monodelphis domestica)
Mammalia LRRD1 30
  • 53 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRRD1 30
  • 43 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRD1 30
  • 48 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrd1 29
  • 55.42 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0170300 29
  • 37.07 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3983 30
  • 24 (a)
ManyToMany
Species where no ortholog for LRRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LRRD1 Gene

ENSEMBL:
Gene Tree for LRRD1 (if available)
TreeFam:
Gene Tree for LRRD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRD1: view image
Alliance of Genome Resources:
Additional Orthologs for LRRD1

Paralogs for LRRD1 Gene

(12) SIMAP similar genes for LRRD1 Gene using alignment to 3 proteins:

  • LRRD1_HUMAN
  • C9IYX3_HUMAN
  • C9K0I1_HUMAN
genes like me logo Genes that share paralogs with LRRD1: view

Variants for LRRD1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRD1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRD1 Gene

Variant ID Type Subtype PubMed ID
esv3614136 CNV loss 21293372
nsv1114987 CNV deletion 24896259
nsv5839 CNV insertion 18451855

Variation tolerance for LRRD1 Gene

Gene Damage Index Score: 10.89; 91.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRD1
Leiden Open Variation Database (LOVD)
LRRD1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRD1 Gene

Disorders for LRRD1 Gene

Additional Disease Information for LRRD1

No disorders were found for LRRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRD1 Gene

Publications for LRRD1 Gene

  1. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  2. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for LRRD1 Gene

Sources for LRRD1 Gene