Aliases for LRRC8E Gene
External Ids for LRRC8E Gene
Previous GeneCards Identifiers for LRRC8E Gene
This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
GeneCards Summary for LRRC8E Gene
LRRC8E (Leucine Rich Repeat Containing 8 VRAC Subunit E) is a Protein Coding gene. Diseases associated with LRRC8E include Steroid-Induced Glaucoma and Hereditary Lymphedema I. An important paralog of this gene is LRRC8C.
UniProtKB/Swiss-Prot Summary for LRRC8E Gene
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).