Aliases for LRRC8D Gene
Aliases for LRRC8D Gene
External Ids for LRRC8D Gene
- HGNC: 16992
- Entrez Gene: 55144
- Ensembl: ENSG00000171492
- OMIM: 612890
- UniProtKB: Q7L1W4
Previous HGNC Symbols for LRRC8D Gene
- LRRC5
Previous GeneCards Identifiers for LRRC8D Gene
- GC01P089999
- GC01P090060
- GC01P090286
- GC01P088403
Summaries for LRRC8D Gene
GeneCards Summary for LRRC8D Gene
LRRC8D (Leucine Rich Repeat Containing 8 VRAC Subunit D) is a Protein Coding gene. An important paralog of this gene is LRRC8A.
UniProtKB/Swiss-Prot Summary for LRRC8D Gene
-
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).
Additional gene information for LRRC8D Gene
- Monarch Initiative
- Search for LRRC8D at DataMed
- Search for LRRC8D at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC8D Gene
Genomics for LRRC8D Gene
GeneHancer (GH) Regulatory Elements for LRRC8D Gene
Promoters and enhancers for LRRC8D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LRRC8D on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LRRC8D gene promoter:
-
- AML1a
- Evi-1
- Hlf
- NF-1
- TBP
Genomic Locations for LRRC8D Gene
Genomic Locations for LRRC8D Gene
- chr1:89,821,014-89,936,611
- (GRCh38/hg38)
- Size:
- 115,598 bases
- Orientation:
- Plus strand
- chr1:90,286,573-90,402,170
- (GRCh37/hg19)
- Size:
- 115,598 bases
- Orientation:
- Plus strand
Genomic View for LRRC8D Gene
Genes around LRRC8D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.2 by HGNC
- 1p22.2 by Entrez Gene
- 1p22.2 by Ensembl
LRRC8D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LRRC8D Gene
Proteins for LRRC8D Gene
-
Protein details for LRRC8D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L1W4-LRC8D_HUMAN
- Recommended name:
- Volume-regulated anion channel subunit LRRC8D
- Protein Accession:
- Q7L1W4
- D3DT29
- Q6UWB2
- Q9NVW3
Protein attributes for LRRC8D Gene
- Size:
- 858 amino acids
- Molecular mass:
- 98201 Da
- Quaternary structure:
-
- Heterohexamer (Probable). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E) to form a heterohexamer (PubMed:24782309, PubMed:26530471, PubMed:28193731, PubMed:26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable).
- SequenceCaution:
-
- Sequence=AAQ89233.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91631.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for LRRC8D Gene
Post-translational modifications for LRRC8D Gene
Other Protein References for LRRC8D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LRRC8D
- Invitrogen Antibodies for LRRC8D (AFLGC-LRRC8D)
- antibodies-online: Show 9 available LRRC8D Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for LRRC8D
- Sino Biological Antibodies for LRRC8D
Protein Products
-
OriGene Purified Proteins for LRRC8D
- Search Origene for MassSpec and Protein Over-expression Lysates for LRRC8D
- Origene Custom Protein Services for LRRC8D
-
Abcam proteins for LRRC8D
No data available for DME Specific Peptides for LRRC8D Gene
Domains & Families for LRRC8D Gene
Gene Families for LRRC8D Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for LRRC8D Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LRRC8D Gene
- GenScript: Design optimal peptide antigens:
-
- Leucine rich repeat containing 8 family, member D (B1AP11_HUMAN)
- Leucine-rich repeat-containing protein 5 (LRC8D_HUMAN)
- LRRC8D protein (Q96GG5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7L1W4- Family:
-
- Belongs to the LRRC8 family.
Function for LRRC8D Gene
Molecular function for LRRC8D Gene
- UniProtKB/Swiss-Prot Function:
- Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).
Phenotypes From GWAS Catalog for LRRC8D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005225 | contributes_to volume-sensitive anion channel activity | IMP | 28193731 |
| GO:0005515 | protein binding | IPI | 24790029 |
Phenotypes for LRRC8D Gene
- MGI mutant phenotypes for LRRC8D:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LRRC8D:
Animal Models for LRRC8D Gene
- MGI Knock Outs for LRRC8D:
-
- Lrrc8d Lrrc8d<tm1a(EUCOMM)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for LRRC8D
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LRRC8D - Select products 50% OFF >
- * LRRC8D CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LRRC8D CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for LRRC8D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRRC8D
- genomics-online: gRNA clones - Search for available LRRC8D gRNA products
- Overview of 134 available LRRC8D gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRC8D
miRNA for LRRC8D Gene
- miRTarBase miRNAs that target LRRC8D
-
- hsa-mir-1-3p (MIRT023944)
- hsa-mir-26b-5p (MIRT029937)
- hsa-mir-454-3p (MIRT039220)
- hsa-mir-615-3p (MIRT040025)
- hsa-mir-30a-5p (MIRT149112)
- hsa-mir-30c-5p (MIRT149115)
- hsa-mir-30d-5p (MIRT149116)
- hsa-mir-181a-5p (MIRT149117)
- hsa-mir-181b-5p (MIRT149118)
- hsa-mir-181c-5p (MIRT149119)
- hsa-mir-30b-5p (MIRT149121)
- hsa-mir-30e-5p (MIRT149122)
- hsa-mir-181d-5p (MIRT149123)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LRRC8D
- Browse OriGene Inhibitory RNA Products For LRRC8D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC8D
- genomics-online: shRNA clones - Search for available LRRC8D shRNA products
- Overview of 134 available LRRC8D gene related products
Clone Products
- Applied Biological Materials (abm): Clones for LRRC8D - Select products 50% OFF >
- * LRRC8D as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LRRC8D tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG210975
- MG217464
- MR210975
- MR210975L3
- MR210975L3V
- MR210975L4
- MR210975L4V
- MR217464
- MR217464L3
- MR217464L3V
- MR217464L4
- MR217464L4V
- RC203641
- RC203641L1
- RC203641L1V
- RC203641L2
- RC203641L2V
- RC203641L3
- RC203641L3V
- RC203641L4
- RC203641L4V
- RC226214
- RC226214L3
- RC226214L3V
- RC226214L4
- RC226214L4V
- RG203641
- RG226214
- RR212831
- RR212831L1
- RR212831L1V
- RR212831L2
- RR212831L2V
- RR212831L3
- RR212831L3V
- RR212831L4
- RR212831L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LRRC8D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRRC8D
Cell Line Products
-
Horizon Cell Lines for LRRC8D
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC8D Gene
Localization for LRRC8D Gene
Subcellular locations from UniProtKB/Swiss-Prot for LRRC8D Gene
- Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). {ECO:0000269 PubMed:24782309, ECO:0000269 PubMed:24790029}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| mitochondrion | 1 |
| peroxisome | 0 |
| cytosol | 0 |
- Mitochondria (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 24790029 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IMP | 26824658 |
Pathways & Interactions for LRRC8D Gene
Interacting Proteins for LRRC8D Gene
Selected Interacting proteins:
Q7L1W4-LRC8D_HUMAN
ENSP00000338887
for LRRC8D Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LRRC8D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0015698 | inorganic anion transport | IEA | -- |
| GO:0015734 | taurine transport | IMP | 28193731 |
| GO:0015810 | aspartate transmembrane transport | IMP | 28193731 |
| GO:0055085 | transmembrane transport | TAS | -- |
No data available for Pathways by source and SIGNOR curated interactions for LRRC8D Gene
Transcripts for LRRC8D Gene
mRNA/cDNA for LRRC8D Gene
- (2) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (126) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000525774 588 bps (ENST00000525774.5)
- ENST00000337338 3950 bps (ENST00000337338.9)
- ENST00000394593 3345 bps (ENST00000394593.7)
- ENST00000532201 597 bps (ENST00000532201.5)
- ENST00000414841 666 bps (ENST00000414841.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LRRC8D - Select products 50% OFF >
- * LRRC8D CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * LRRC8D CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for LRRC8D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRRC8D
- genomics-online: gRNA clones - Search for available LRRC8D gRNA products
- Overview of 134 available LRRC8D gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRC8D
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LRRC8D
- Browse OriGene Inhibitory RNA Products For LRRC8D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC8D
- genomics-online: shRNA clones - Search for available LRRC8D shRNA products
- Overview of 134 available LRRC8D gene related products
Clone Products
- Applied Biological Materials (abm): Clones for LRRC8D - Select products 50% OFF >
- * LRRC8D as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * LRRC8D tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG210975
- MG217464
- MR210975
- MR210975L3
- MR210975L3V
- MR210975L4
- MR210975L4V
- MR217464
- MR217464L3
- MR217464L3V
- MR217464L4
- MR217464L4V
- RC203641
- RC203641L1
- RC203641L1V
- RC203641L2
- RC203641L2V
- RC203641L3
- RC203641L3V
- RC203641L4
- RC203641L4V
- RC226214
- RC226214L3
- RC226214L3V
- RC226214L4
- RC226214L4V
- RG203641
- RG226214
- RR212831
- RR212831L1
- RR212831L1V
- RR212831L2
- RR212831L2V
- RR212831L3
- RR212831L3V
- RR212831L4
- RR212831L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LRRC8D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRRC8D
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||
| SP7: | - |
Expression for LRRC8D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
This gene is overexpressed in Adrenal (43.8), Lung (13.5), and Peripheral blood mononuclear cells (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC8D Gene
NURSA nuclear receptor signaling pathways regulating expression of LRRC8D Gene:
LRRC8DSOURCE GeneReport for Unigene cluster for LRRC8D Gene:
Hs.482087Evidence on tissue expression from TISSUES for LRRC8D Gene
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for LRRC8D
-
OriGene qPCR primer pairs and template standards for LRRC8D
- genomics-online: primer clones - Search for available LRRC8D Primer products
- Overview of 134 available LRRC8D gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC8D Gene
Orthologs for LRRC8D Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LRRC8D 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LRRC8D 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LRRC8D 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Lrrc8d 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Lrrc8d 17 33 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LRRC8D 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LRRC8D 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | LRRC8D 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lrrc8d 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lrrc8db 33 32 |
|
OneToOne | |
| Dr.19720 32 |
|
- Species where no ortholog for LRRC8D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for LRRC8D Gene
- ENSEMBL:
- Gene Tree for LRRC8D (if available)
- TreeFam:
- Gene Tree for LRRC8D (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LRRC8D: view image
Paralogs for LRRC8D Gene
Paralogs for LRRC8D Gene
(7) SIMAP similar genes for LRRC8D Gene using alignment to 7 proteins:
- LRC8D_HUMAN
- E9PJ89_HUMAN
- E9PJS7_HUMAN
- E9PL08_HUMAN
- E9PMF9_HUMAN
- Q5VWA0_HUMAN
- Q96GG5_HUMAN
Variants for LRRC8D Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025483 | -- | 89,821,379(+) | C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000037636 | -- | 89,864,004(+) | A/G | intron_variant | |
| rs1000053139 | -- | 89,877,600(+) | G/A | intron_variant | |
| rs1000056223 | -- | 89,906,691(+) | A/G | intron_variant | |
| rs1000056682 | -- | 89,821,482(+) | T/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3303537 | CNV | mobile element insertion | 20981092 |
| esv3331862 | CNV | insertion | 20981092 |
| esv3388679 | CNV | insertion | 20981092 |
| esv3586772 | CNV | gain | 21293372 |
| nsv1000666 | CNV | gain | 25217958 |
| nsv1832 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
8.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.68;
32.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LRRC8D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LRRC8D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC8D Gene
Disorders for LRRC8D Gene
Additional Disease Information for LRRC8D
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for LRRC8D Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC8D Gene
Publications for LRRC8D Gene
- Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. (PMID: 24790029) Voss FK … Jentsch TJ (Science (New York, N.Y.) 2014) 2 3 4 56
- Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels. (PMID: 28193731) Lutter D … Jentsch TJ (Journal of cell science 2017) 3 4 56
- LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. (PMID: 26824658) Syeda R … Patapoutian A (Cell 2016) 3 4 56
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
ExternalLinks
Products for LRRC8D Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for LRRC8D
- Search Origene for MassSpec and Protein Over-expression Lysates for LRRC8D
- Origene Custom Protein Services for LRRC8D
- Origene sirna, shrna, and RNAi products in human, mouse, rat for LRRC8D
- Browse OriGene Inhibitory RNA Products For LRRC8D
- OriGene qPCR primer pairs for LRRC8D
- OriGene qPCR primer pairs and template standards for LRRC8D
- OriGene CRISPR knockouts for LRRC8D
- MG210975
- MG217464
- MR210975
- MR210975L3
- MR210975L3V
- MR210975L4
- MR210975L4V
- MR217464
- MR217464L3
- MR217464L3V
- MR217464L4
- MR217464L4V
- RC203641
- RC203641L1
- RC203641L1V
- RC203641L2
- RC203641L2V
- RC203641L3
- RC203641L3V
- RC203641L4
- RC203641L4V
- RC226214
- RC226214L3
- RC226214L3V
- RC226214L4
- RC226214L4V
- RG203641
- RG226214
- RR212831
- RR212831L1
- RR212831L1V
- RR212831L2
- RR212831L2V
- RR212831L3
- RR212831L3V
- RR212831L4
- RR212831L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Taconic Biosciences Mouse Models for LRRC8D
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- antibodies-online: Show 9 available LRRC8D Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for LRRC8D
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- genomics-online: cdna clones - Search for available LRRC8D CDNA products
- Overview of 134 available LRRC8D gene related products
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- Overview of 134 available LRRC8D gene related products
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- Overview of 134 available LRRC8D gene related products
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Sources for LRRC8D Gene
- (1) GeneCards
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- (5) Ensembl
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- (7) GeneLoc
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- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
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- (35) SGD
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- (38) Pseudogene
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- (46) Atlas
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- (48) H-invDB
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- (70) Reactome
- (71) GeneGo (Thomson Reuters)
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- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
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