Aliases for LRRC75B Gene

Aliases for LRRC75B Gene

  • Leucine Rich Repeat Containing 75B 2 3 5
  • Leucine-Rich Repeat-Containing Protein FAM211B 3 4
  • Family With Sequence Similarity 211, Member B 2 3
  • Leucine-Rich Repeat-Containing Protein 75B 3 4
  • C22orf36 3 4
  • FAM211B 3 4
  • Leucine-Rich Repeat-Containing Protein C22orf36 3
  • Chromosome 22 Open Reading Frame 36 2
  • MGC131773 2
  • LRRC75B 5

External Ids for LRRC75B Gene

Previous HGNC Symbols for LRRC75B Gene

  • C22orf36
  • FAM211B

Previous GeneCards Identifiers for LRRC75B Gene

  • GC22M025185

Summaries for LRRC75B Gene

GeneCards Summary for LRRC75B Gene

LRRC75B (Leucine Rich Repeat Containing 75B) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC75B Gene

Genomics for LRRC75B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC75B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC75B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC75B

Genomic Locations for LRRC75B Gene

Latest Assembly
chr22:24,585,620-24,593,208
(GRCh38/hg38)
Size:
7,589 bases
Orientation:
Minus strand

Previous Assembly
chr22:24,981,603-24,989,040
(GRCh37/hg19 by Entrez Gene)
Size:
7,438 bases
Orientation:
Minus strand

chr22:24,981,588-24,989,175
(GRCh37/hg19 by Ensembl)
Size:
7,588 bases
Orientation:
Minus strand

Genomic View for LRRC75B Gene

Genes around LRRC75B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC75B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC75B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC75B Gene

Proteins for LRRC75B Gene

  • Protein details for LRRC75B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VPJ9-LR75B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 75B
    Protein Accession:
    Q2VPJ9
    Secondary Accessions:
    • Q8N0S9
    • Q8N8B1

    Protein attributes for LRRC75B Gene

    Size:
    315 amino acids
    Molecular mass:
    34740 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC75B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC75B Gene

Post-translational modifications for LRRC75B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC75B Gene

No data available for DME Specific Peptides for LRRC75B Gene

Domains & Families for LRRC75B Gene

Gene Families for LRRC75B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC75B Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature

Suggested Antigen Peptide Sequences for LRRC75B Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein C22orf36 (LRC6X_HUMAN)
  • C22orf36 protein (Q8WVQ4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2VPJ9

UniProtKB/Swiss-Prot:

LR75B_HUMAN :
  • Belongs to the LRRC75 family.
Family:
  • Belongs to the LRRC75 family.
genes like me logo Genes that share domains with LRRC75B: view

Function for LRRC75B Gene

Phenotypes From GWAS Catalog for LRRC75B Gene

genes like me logo Genes that share phenotypes with LRRC75B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC75B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC75B Gene

Localization for LRRC75B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC75B gene
Compartment Confidence
extracellular 1
nucleus 1
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC75B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with LRRC75B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC75B Gene

Pathways & Interactions for LRRC75B Gene

PathCards logo

SuperPathways for LRRC75B Gene

No Data Available

Interacting Proteins for LRRC75B Gene

Selected Interacting proteins: Q2VPJ9-LR75B_HUMAN for LRRC75B Gene via IID

Symbol External ID(s) Details
SIX5

Gene Ontology (GO) - Biological Process for LRRC75B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC75B Gene

Drugs & Compounds for LRRC75B Gene

No Compound Related Data Available

Transcripts for LRRC75B Gene

mRNA/cDNA for LRRC75B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC75B

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC75B Gene

No ASD Table

Relevant External Links for LRRC75B Gene

GeneLoc Exon Structure for
LRRC75B

Expression for LRRC75B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC75B Gene

Protein differential expression in normal tissues from HIPED for LRRC75B Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC75B Gene



Protein tissue co-expression partners for LRRC75B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC75B

Evidence on tissue expression from TISSUES for LRRC75B Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Kidney(3.2)
genes like me logo Genes that share expression patterns with LRRC75B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC75B Gene

Orthologs for LRRC75B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC75B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM211B 29 30
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100682757 29
  • 86.32 (n)
FAM211B 30
  • 54 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam211b 29 30
  • 83.88 (n)
OneToOne
Lrrc75b 16
Rat
(Rattus norvegicus)
Mammalia Fam211b 29
  • 83.44 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM211B 30
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C22ORF36 29
  • 69.29 (n)
FAM211B 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam211b 29
  • 62.84 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100148888 29
  • 62.12 (n)
fam211ba 30
  • 46 (a)
OneToMany
BX005006.2 30
  • 44 (a)
OneToMany
Species where no ortholog for LRRC75B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRRC75B Gene

ENSEMBL:
Gene Tree for LRRC75B (if available)
TreeFam:
Gene Tree for LRRC75B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC75B: view image
Alliance of Genome Resources:
Additional Orthologs for LRRC75B

Paralogs for LRRC75B Gene

Pseudogenes.org Pseudogenes for LRRC75B Gene

genes like me logo Genes that share paralogs with LRRC75B: view

No data available for Paralogs for LRRC75B Gene

Variants for LRRC75B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC75B Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs743370 -- p.Ser140Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRC75B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRC75B Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv2724068 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893463 CNV gain 25118596
nsv1055830 CNV gain 25217958
nsv1057819 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv588744 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv9884 CNV gain+loss 18304495

Variation tolerance for LRRC75B Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC75B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC75B
Leiden Open Variation Database (LOVD)
LRRC75B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC75B Gene

Disorders for LRRC75B Gene

Additional Disease Information for LRRC75B

No disorders were found for LRRC75B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC75B Gene

Publications for LRRC75B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim YJ … Cho YS (Nature genetics 2011) 3
  5. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PMID: 18940312) Yuan X … Mooser V (American journal of human genetics 2008) 3

Products for LRRC75B Gene

Sources for LRRC75B Gene