Aliases for LRRC75A Gene

Aliases for LRRC75A Gene

  • Leucine Rich Repeat Containing 75A 2 3 5
  • Leucine-Rich Repeat-Containing Protein FAM211A 3 4
  • Family With Sequence Similarity 211, Member A 2 3
  • Leucine-Rich Repeat-Containing Protein 75A 3 4
  • C17orf76 3 4
  • FAM211A 3 4
  • Leucine-Rich Repeat-Containing Protein C17orf76 3
  • Chromosome 17 Open Reading Frame 76 2

External Ids for LRRC75A Gene

Previous HGNC Symbols for LRRC75A Gene

  • C17orf76
  • FAM211A

Previous GeneCards Identifiers for LRRC75A Gene

  • GC17M016346

Summaries for LRRC75A Gene

GeneCards Summary for LRRC75A Gene

LRRC75A (Leucine Rich Repeat Containing 75A) is a Protein Coding gene.

Additional gene information for LRRC75A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC75A Gene

Genomics for LRRC75A Gene

GeneHancer (GH) Regulatory Elements for LRRC75A Gene

Promoters and enhancers for LRRC75A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC75A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC75A

Genomic Locations for LRRC75A Gene

Genomic Locations for LRRC75A Gene
chr17:16,441,577-16,492,193
(GRCh38/hg38)
Size:
50,617 bases
Orientation:
Minus strand
chr17:16,344,891-16,395,480
(GRCh37/hg19)
Size:
50,590 bases
Orientation:
Minus strand

Genomic View for LRRC75A Gene

Genes around LRRC75A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC75A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC75A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC75A Gene

Proteins for LRRC75A Gene

  • Protein details for LRRC75A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAA5-LR75A_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 75A
    Protein Accession:
    Q8NAA5

    Protein attributes for LRRC75A Gene

    Size:
    344 amino acids
    Molecular mass:
    37780 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC75A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC75A Gene

Post-translational modifications for LRRC75A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC75A Gene

No data available for DME Specific Peptides for LRRC75A Gene

Domains & Families for LRRC75A Gene

Gene Families for LRRC75A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC75A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC75A Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein C17orf76 (CQ076_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NAA5

UniProtKB/Swiss-Prot:

LR75A_HUMAN :
  • Belongs to the LRRC75 family.
Family:
  • Belongs to the LRRC75 family.
genes like me logo Genes that share domains with LRRC75A: view

Function for LRRC75A Gene

Phenotypes From GWAS Catalog for LRRC75A Gene

genes like me logo Genes that share phenotypes with LRRC75A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC75A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC75A Gene

Localization for LRRC75A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC75A gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with LRRC75A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC75A Gene

Pathways & Interactions for LRRC75A Gene

PathCards logo

SuperPathways for LRRC75A Gene

No Data Available

Interacting Proteins for LRRC75A Gene

;

Gene Ontology (GO) - Biological Process for LRRC75A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC75A Gene

Drugs & Compounds for LRRC75A Gene

No Compound Related Data Available

Transcripts for LRRC75A Gene

mRNA/cDNA for LRRC75A Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC75A

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC75A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for LRRC75A Gene

GeneLoc Exon Structure for
LRRC75A

Expression for LRRC75A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC75A Gene

mRNA differential expression in normal tissues according to GTEx for LRRC75A Gene

This gene is overexpressed in Colon - Transverse (x6.5), Small Intestine - Terminal Ileum (x4.6), and Adrenal Gland (x4.5).

Protein differential expression in normal tissues from HIPED for LRRC75A Gene

This gene is overexpressed in Cerebrospinal fluid (38.1), Heart (12.4), and Frontal cortex (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC75A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC75A

Evidence on tissue expression from TISSUES for LRRC75A Gene

  • Lung(4.6)
  • Nervous system(4.6)
  • Liver(4.1)
  • Stomach(4)
  • Intestine(3.9)
  • Eye(3.6)
  • Skin(3.3)
  • Heart(2.5)
  • Bone(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LRRC75A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC75A Gene

Orthologs for LRRC75A Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC75A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM211A 31 30
  • 99.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM211A 31 30
  • 90.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM211A 31 30
  • 89.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam211a 31 30
  • 87.7 (n)
OneToOne
Lrrc75a 17
rat
(Rattus norvegicus)
Mammalia Fam211a 30
  • 85.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FAM211A 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19H17ORF76 30
  • 72.56 (n)
FAM211A 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM211A 31
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495315 30
  • 66.87 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562936 30
  • 68.57 (n)
FAM211A 31
  • 48 (a)
OneToOne
Species where no ortholog for LRRC75A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC75A Gene

ENSEMBL:
Gene Tree for LRRC75A (if available)
TreeFam:
Gene Tree for LRRC75A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC75A: view image

Paralogs for LRRC75A Gene

No data available for Paralogs for LRRC75A Gene

Variants for LRRC75A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC75A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
788905 Benign: not provided 16,443,931(-) C/T MISSENSE_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for LRRC75A Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC75A Gene

Variant ID Type Subtype PubMed ID
dgv5475n54 CNV gain 21841781
dgv5476n54 CNV gain+loss 21841781
esv2715702 CNV deletion 23290073
esv28979 CNV loss 19812545
esv3640102 CNV gain 21293372
esv3640103 CNV gain 21293372
nsv1063764 CNV loss 25217958
nsv1063941 CNV gain 25217958
nsv1070815 CNV deletion 25765185
nsv1118746 CNV deletion 24896259
nsv478412 CNV novel sequence insertion 20440878
nsv574487 CNV gain 21841781
nsv574494 CNV gain 21841781
nsv953836 CNV deletion 24416366

Variation tolerance for LRRC75A Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC75A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC75A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC75A Gene

Disorders for LRRC75A Gene

Additional Disease Information for LRRC75A

No disorders were found for LRRC75A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC75A Gene

Publications for LRRC75A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. Identification and analysis of intermediate size noncoding RNAs in the human fetal brain. (PMID: 21789175) Yan D … Chen R (PloS one 2011) 3 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 54
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 54

Products for LRRC75A Gene

Sources for LRRC75A Gene