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Aliases for LRRC75A Gene

Aliases for LRRC75A Gene

  • Leucine Rich Repeat Containing 75A 2 3 5
  • Leucine-Rich Repeat-Containing Protein FAM211A 3 4
  • Family With Sequence Similarity 211, Member A 2 3
  • C17orf76 3 4
  • FAM211A 3 4
  • Leucine-Rich Repeat-Containing Protein C17orf76 3
  • Leucine-Rich Repeat-Containing Protein 75A 3
  • Chromosome 17 Open Reading Frame 76 2

External Ids for LRRC75A Gene

Previous HGNC Symbols for LRRC75A Gene

  • C17orf76
  • FAM211A

Previous GeneCards Identifiers for LRRC75A Gene

  • GC17M016346

Summaries for LRRC75A Gene

GeneCards Summary for LRRC75A Gene

LRRC75A (Leucine Rich Repeat Containing 75A) is a Protein Coding gene. An important paralog of this gene is LRRC75B.

Additional gene information for LRRC75A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC75A Gene

Genomics for LRRC75A Gene

GeneHancer (GH) Regulatory Elements for LRRC75A Gene

Promoters and enhancers for LRRC75A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I016484 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.1 +3.7 3725 8.3 HDAC1 RB1 NFIB ZSCAN4 KLF17 ZNF335 TCF12 GLIS2 SCRT2 EGR2 LRRC75A ZNF286A ENSG00000266538 PPIAP53 PIGL MPRIP-AS1 MEIS3P1 ENSG00000265519 TVP23C CDRT4
GH17I016462 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 23 +24.9 24944 8.9 CTCF TFAP4 ZNF146 KLF1 FOXA2 RARA GATA3 RERE POLR2A SMC3 LRRC75A-AS1 LRRC75A PLD6 PIGL GC17M016479 PIR35161
GH17I016516 Enhancer 1.2 FANTOM5 Ensembl ENCODE 21.6 -24.6 -24556 1.3 FEZF1 ZBTB40 RFX5 ZNF335 ZNF366 EGR1 ZSCAN5C SCRT2 FOS CREM LRRC75A LRRC75A-AS1 GC17P016523 GC17M016496
GH17I016351 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 +139.5 139522 2.8 FOXA2 ARID4B SIN3A FEZF1 DMAP1 GLI4 ZNF48 YY1 ZNF766 GLIS2 CENPV NCOR1 LRRC75A FLCN NT5M MEIS3P1 GC17M016347 PIGL
GH17I016406 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +84.5 84480 2.2 HDGF SMAD1 ZFP64 SIN3A FEZF1 YBX1 IRF4 ZNF213 ZNF207 ZNF548 PIGL PPIAP53 ENSG00000266538 NCOR1 TVP23C MPRIP-AS1 ZNF286A LOC644422 UPF3AP1 MPRIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC75A on UCSC Golden Path with GeneCards custom track

Genomic Locations for LRRC75A Gene

Genomic Locations for LRRC75A Gene
50,615 bases
Minus strand

Genomic View for LRRC75A Gene

Genes around LRRC75A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC75A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC75A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC75A Gene

Proteins for LRRC75A Gene

  • Protein details for LRRC75A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 75A
    Protein Accession:

    Protein attributes for LRRC75A Gene

    344 amino acids
    Molecular mass:
    37780 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC75A Gene


neXtProt entry for LRRC75A Gene

Post-translational modifications for LRRC75A Gene

No Post-translational modifications

Other Protein References for LRRC75A Gene

No data available for DME Specific Peptides for LRRC75A Gene

Domains & Families for LRRC75A Gene

Gene Families for LRRC75A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC75A Gene


Suggested Antigen Peptide Sequences for LRRC75A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LRRC75 family.
  • Belongs to the LRRC75 family.
genes like me logo Genes that share domains with LRRC75A: view

Function for LRRC75A Gene

Phenotypes From GWAS Catalog for LRRC75A Gene

genes like me logo Genes that share phenotypes with LRRC75A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC75A Gene

Localization for LRRC75A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC75A gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC75A Gene

Pathways & Interactions for LRRC75A Gene

SuperPathways for LRRC75A Gene

No Data Available

Interacting Proteins for LRRC75A Gene

Gene Ontology (GO) - Biological Process for LRRC75A Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC75A Gene

Drugs & Compounds for LRRC75A Gene

No Compound Related Data Available

Transcripts for LRRC75A Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC75A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for LRRC75A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC75A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC75A Gene

mRNA differential expression in normal tissues according to GTEx for LRRC75A Gene

This gene is overexpressed in Colon - Transverse (x6.5), Small Intestine - Terminal Ileum (x4.6), and Adrenal Gland (x4.5).

Protein differential expression in normal tissues from HIPED for LRRC75A Gene

This gene is overexpressed in Cerebrospinal fluid (38.1), Heart (12.4), and Frontal cortex (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC75A Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC75A Gene:


Evidence on tissue expression from TISSUES for LRRC75A Gene

  • Lung(4.6)
  • Nervous system(4.6)
  • Liver(4.1)
  • Stomach(4)
  • Intestine(3.9)
  • Eye(3.6)
  • Skin(3.3)
  • Heart(2.5)
  • Bone(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LRRC75A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC75A Gene

Orthologs for LRRC75A Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC75A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM211A 33 34
  • 99.81 (n)
(Canis familiaris)
Mammalia FAM211A 33 34
  • 90.83 (n)
(Bos Taurus)
Mammalia FAM211A 33 34
  • 89.6 (n)
(Mus musculus)
Mammalia Fam211a 33 34
  • 87.7 (n)
Lrrc75a 16
(Rattus norvegicus)
Mammalia Fam211a 33
  • 85.94 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
-- 34
  • 74 (a)
(Monodelphis domestica)
Mammalia FAM211A 34
  • 68 (a)
(Gallus gallus)
Aves C19H17ORF76 33
  • 72.56 (n)
FAM211A 34
  • 62 (a)
(Anolis carolinensis)
Reptilia FAM211A 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495315 33
  • 66.87 (n)
(Danio rerio)
Actinopterygii LOC562936 33
  • 68.57 (n)
FAM211A 34
  • 48 (a)
Species where no ortholog for LRRC75A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC75A Gene

Gene Tree for LRRC75A (if available)
Gene Tree for LRRC75A (if available)

Paralogs for LRRC75A Gene

Paralogs for LRRC75A Gene

genes like me logo Genes that share paralogs with LRRC75A: view

Variants for LRRC75A Gene

Sequence variations from dbSNP and Humsavar for LRRC75A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000110017 -- 16,458,946(-) A/G intron_variant
rs1000128171 -- 16,458,670(-) G/A intron_variant
rs1000181144 -- 16,468,459(-) C/T intron_variant
rs1000252494 -- 16,491,524(-) G/C/T genic_upstream_transcript_variant, intron_variant
rs1000281348 -- 16,471,836(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC75A Gene

Variant ID Type Subtype PubMed ID
nsv953836 CNV deletion 24416366
nsv574494 CNV gain 21841781
nsv574487 CNV gain 21841781
nsv478412 CNV novel sequence insertion 20440878
nsv1118746 CNV deletion 24896259
nsv1070815 CNV deletion 25765185
nsv1063941 CNV gain 25217958
nsv1063764 CNV loss 25217958
esv3640103 CNV gain 21293372
esv3640102 CNV gain 21293372
esv28979 CNV loss 19812545
esv2715702 CNV deletion 23290073
dgv5476n54 CNV gain+loss 21841781
dgv5475n54 CNV gain 21841781

Variation tolerance for LRRC75A Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC75A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC75A Gene

Disorders for LRRC75A Gene

Additional Disease Information for LRRC75A

No disorders were found for LRRC75A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC75A Gene

Publications for LRRC75A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. Identification and analysis of intermediate size noncoding RNAs in the human fetal brain. (PMID: 21789175) Yan D … Chen R (PloS one 2011) 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for LRRC75A Gene

Sources for LRRC75A Gene

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