Aliases for LRRC74A Gene

Aliases for LRRC74A Gene

  • Leucine Rich Repeat Containing 74A 2 3 5
  • LRRC74 2 3 4
  • Leucine-Rich Repeat-Containing Protein 74A 3 4
  • Leucine-Rich Repeat-Containing Protein 74 3 4
  • Leucine Rich Repeat Containing 74 2 3
  • C14orf166B 3 4
  • Chromosome 14 Open Reading Frame 166B 2
  • LRRC74A 5

External Ids for LRRC74A Gene

Previous HGNC Symbols for LRRC74A Gene

  • C14orf166B
  • LRRC74

Summaries for LRRC74A Gene

GeneCards Summary for LRRC74A Gene

LRRC74A (Leucine Rich Repeat Containing 74A) is a Protein Coding gene. Diseases associated with LRRC74A include Twin-To-Twin Transfusion Syndrome and Exstrophy Of Bladder. An important paralog of this gene is LRRC74B.

Additional gene information for LRRC74A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC74A Gene

Genomics for LRRC74A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC74A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC74A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC74A

Genomic Locations for LRRC74A Gene

Genomic Locations for LRRC74A Gene
43,933 bases
Plus strand
43,931 bases
Plus strand

Genomic View for LRRC74A Gene

Genes around LRRC74A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC74A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC74A Gene

Proteins for LRRC74A Gene

  • Protein details for LRRC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 74A
    Protein Accession:
    Secondary Accessions:
    • Q6ZUG6
    • Q9Y627

    Protein attributes for LRRC74A Gene

    488 amino acids
    Molecular mass:
    54535 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD44364.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAI21160.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI21161.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW81265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC74A Gene


neXtProt entry for LRRC74A Gene

Post-translational modifications for LRRC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC74A Gene

Domains & Families for LRRC74A Gene

Gene Families for LRRC74A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC74A Gene


Suggested Antigen Peptide Sequences for LRRC74A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54821 (B4DX10_HUMAN)
genes like me logo Genes that share domains with LRRC74A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC74A Gene

Function for LRRC74A Gene

Phenotypes From GWAS Catalog for LRRC74A Gene

Gene Ontology (GO) - Molecular Function for LRRC74A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC74A: view
genes like me logo Genes that share phenotypes with LRRC74A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC74A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC74A Gene

Localization for LRRC74A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC74A gene
Compartment Confidence
nucleus 1
cytosol 1
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC74A Gene

Pathways & Interactions for LRRC74A Gene

PathCards logo

SuperPathways for LRRC74A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC74A Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC74A Gene

Drugs & Compounds for LRRC74A Gene

No Compound Related Data Available

Transcripts for LRRC74A Gene

mRNA/cDNA for LRRC74A Gene

9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC74A

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC74A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: -

Relevant External Links for LRRC74A Gene

GeneLoc Exon Structure for

Expression for LRRC74A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC74A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC74A Gene

This gene is overexpressed in Plasma (31.5), Heart (23.2), and Cardia (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC74A Gene

Protein tissue co-expression partners for LRRC74A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC74A

genes like me logo Genes that share expression patterns with LRRC74A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC74A Gene

Orthologs for LRRC74A Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC74A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14orf166B 31
  • 99 (a)
LRRC74 30
  • 98.77 (n)
(Bos Taurus)
Mammalia LRRC74 30
  • 82.17 (n)
C14orf166B 31
  • 71 (a)
(Canis familiaris)
Mammalia LRRC74 30
  • 81.56 (n)
C14orf166B 31
  • 74 (a)
(Mus musculus)
Mammalia Gm6772 30 31
  • 78.41 (n)
Lrrc74a 17
(Rattus norvegicus)
Mammalia LOC314328 30
  • 78.09 (n)
(Ornithorhynchus anatinus)
Mammalia C14orf166B 31
  • 64 (a)
(Monodelphis domestica)
Mammalia C14orf166B 31
  • 56 (a)
(Gallus gallus)
Aves C5H14ORF166B 30
  • 62.14 (n)
C14orf166B 31
  • 45 (a)
(Anolis carolinensis)
Reptilia C14orf166B 31
  • 52 (a)
(Danio rerio)
Actinopterygii LOC101886467 30
  • 59.49 (n)
C17H14orf166B 31
  • 49 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG14325 31
  • 13 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4124 31
  • 33 (a)
Species where no ortholog for LRRC74A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRRC74A Gene

Gene Tree for LRRC74A (if available)
Gene Tree for LRRC74A (if available)
Evolutionary constrained regions (ECRs) for LRRC74A: view image

Paralogs for LRRC74A Gene

Paralogs for LRRC74A Gene

genes like me logo Genes that share paralogs with LRRC74A: view

Variants for LRRC74A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC74A Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
714520 Benign: not provided 76,870,118(+) G/T INTRON_VARIANT
776850 Benign: not provided 76,853,350(+) T/C SYNONYMOUS_VARIANT
781148 Benign: not provided 76,865,958(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for LRRC74A Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC74A Gene

Variant ID Type Subtype PubMed ID
esv2748891 CNV deletion 23290073
esv2748892 CNV deletion 23290073
esv2748893 CNV deletion 23290073
esv3303605 CNV mobile element insertion 20981092
esv3341226 CNV insertion 20981092
esv3378063 CNV duplication 20981092
nsv1070645 CNV deletion 25765185
nsv1126369 CNV deletion 24896259
nsv517919 CNV loss 19592680
nsv522389 CNV gain 19592680

Variation tolerance for LRRC74A Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC74A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC74A Gene

Disorders for LRRC74A Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC74A Gene - From: DISEASES

Disorder Aliases PubMed IDs
twin-to-twin transfusion syndrome
  • twin twin transfusion syndrome
exstrophy of bladder
  • bladder exstrophy
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with LRRC74A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC74A Gene

Publications for LRRC74A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4

Products for LRRC74A Gene

Sources for LRRC74A Gene