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Aliases for LRRC71 Gene

Aliases for LRRC71 Gene

  • Leucine Rich Repeat Containing 71 2 3 5
  • Leucine-Rich Repeat-Containing Protein 71 3 4
  • C1orf92 3 4
  • Leucine-Rich Repeat-Containing Protein C10orf92 3
  • Chromosome 1 Open Reading Frame 92 2

External Ids for LRRC71 Gene

Previous HGNC Symbols for LRRC71 Gene

  • C1orf92

Previous GeneCards Identifiers for LRRC71 Gene

  • GC01P156891

Summaries for LRRC71 Gene

GeneCards Summary for LRRC71 Gene

LRRC71 (Leucine Rich Repeat Containing 71) is a Protein Coding gene.

Additional gene information for LRRC71 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC71 Gene

Genomics for LRRC71 Gene

GeneHancer (GH) Regulatory Elements for LRRC71 Gene

Promoters and enhancers for LRRC71 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156919 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 646.6 0.0 -7 0.8 CC2D1A CTCF MLLT1 SP7 SP5 KLF14 EGR1 GMEB1 ARID2 ZBTB8A LRRC71 GC01P156919 KHDC4 PRCC ARHGEF11
GH01J157044 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 41.5 +124.6 124593 4.8 ZNF652 ELF3 ZFX ZNF148 POLR2A MLLT1 CEBPG ZNF384 ZNF687 SP5 ARHGEF11 LRRC71 PRCC RN7SL612P GC01M156985
GH01J156913 Enhancer 1.1 Ensembl ENCODE 50.4 -6.6 -6584 2.2 ZFX CBFA2T2 ZNF148 MLLT1 GTF2F1 TRIM24 ZNF639 EGR1 SMARCA4 MTA1 LRRC71 ARHGEF11 GC01P156919 PEAR1
GH01J156959 Enhancer 0.8 Ensembl ENCODE 46.6 +39.0 39029 0.7 ZSCAN21 SP7 PRDM1 PKNOX1 SP2 OSR2 ZBTB17 NR2C2 ZNF18 FOXK2 LRRC71 MIR765 ARHGEF11 PEAR1 RN7SL612P GC01M156985 GC01P156919
GH01J156891 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -22.3 -22308 13 CC2D1A ZFX CTCF CBFA2T2 GTF2F1 MCM2 ZBTB7A TRIM24 SP7 SP5 ARHGEF11 LRRC71 RRNAD1 KHDC4 INSRR NTRK1 MIR765 ENSG00000223356 PEAR1 GC01P156919
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC71 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LRRC71 Gene

Genomic Locations for LRRC71 Gene
chr1:156,920,608-156,942,683
(GRCh38/hg38)
Size:
22,076 bases
Orientation:
Plus strand
chr1:156,890,424-156,902,886
(GRCh37/hg19)
Size:
12,463 bases
Orientation:
Plus strand

Genomic View for LRRC71 Gene

Genes around LRRC71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC71 Gene

Proteins for LRRC71 Gene

  • Protein details for LRRC71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4P6-LRC71_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 71
    Protein Accession:
    Q8N4P6
    Secondary Accessions:
    • Q96M24

    Protein attributes for LRRC71 Gene

    Size:
    559 amino acids
    Molecular mass:
    61825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC71 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC71 Gene

Post-translational modifications for LRRC71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC71 Gene

Domains & Families for LRRC71 Gene

Gene Families for LRRC71 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC71 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 71 (LRC71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC71: view

No data available for UniProtKB/Swiss-Prot for LRRC71 Gene

Function for LRRC71 Gene

Phenotypes From GWAS Catalog for LRRC71 Gene

genes like me logo Genes that share phenotypes with LRRC71: view

Animal Models for LRRC71 Gene

MGI Knock Outs for LRRC71:
  • Lrrc71 Lrrc71<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC71

Clone Products

  • Applied Biological Materials (abm): Clones for LRRC71 - Now 50% OFF >
  • * LRRC71 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LRRC71 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC71 Gene

Localization for LRRC71 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC71 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC71 Gene

Pathways & Interactions for LRRC71 Gene

PathCards logo

SuperPathways for LRRC71 Gene

No Data Available

Interacting Proteins for LRRC71 Gene

Gene Ontology (GO) - Biological Process for LRRC71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC71 Gene

Drugs & Compounds for LRRC71 Gene

No Compound Related Data Available

Transcripts for LRRC71 Gene

mRNA/cDNA for LRRC71 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for LRRC71 Gene

Leucine rich repeat containing 71:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC71

Clone Products

  • Applied Biological Materials (abm): Clones for LRRC71 - Now 50% OFF >
  • * LRRC71 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LRRC71 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC71 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - - -

Relevant External Links for LRRC71 Gene

GeneLoc Exon Structure for
LRRC71
ECgene alternative splicing isoforms for
LRRC71

Expression for LRRC71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC71 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC71 Gene

This gene is overexpressed in Testis (x27.1) and Fallopian Tube (x5.0).

Protein differential expression in normal tissues from HIPED for LRRC71 Gene

This gene is overexpressed in Plasma (37.8) and Saliva (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC71 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC71 Gene:

LRRC71

SOURCE GeneReport for Unigene cluster for LRRC71 Gene:

Hs.491734
genes like me logo Genes that share expression patterns with LRRC71: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC71 Gene

Orthologs for LRRC71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC71 35 34
  • 98.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC71 34
  • 88.24 (n)
C3H1ORF92 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC71 35 34
  • 85.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc71 34
  • 82.79 (n)
mouse
(Mus musculus)
Mammalia Lrrc71 17 35 34
  • 82.19 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC71 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC71 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC71 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc71 34
  • 56.59 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-81a5.5 34
  • 53.02 (n)
LRRC71 35
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3231 35
  • 40 (a)
OneToOne
Species where no ortholog for LRRC71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC71 Gene

ENSEMBL:
Gene Tree for LRRC71 (if available)
TreeFam:
Gene Tree for LRRC71 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC71: view image

Paralogs for LRRC71 Gene

No data available for Paralogs for LRRC71 Gene

Variants for LRRC71 Gene

Sequence variations from dbSNP and Humsavar for LRRC71 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000005794 -- 156,924,320(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000129944 -- 156,923,944(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000142788 -- 156,924,001(+) G/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000294787 -- 156,930,104(+) /C/G genic_downstream_transcript_variant, intron_variant
rs1000356562 -- 156,930,030(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC71 Gene

Variant ID Type Subtype PubMed ID
esv3890682 CNV loss 25118596
nsv831659 CNV loss 17160897

Variation tolerance for LRRC71 Gene

Gene Damage Index Score: 13.71; 95.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC71 Gene

Disorders for LRRC71 Gene

Additional Disease Information for LRRC71

No disorders were found for LRRC71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC71 Gene

Publications for LRRC71 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for LRRC71 Gene

Sources for LRRC71 Gene

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