Free for academic non-profit institutions. Other users need a Commercial license
LRRC7 (Leucine Rich Repeat Containing 7) is a Protein Coding gene. Diseases associated with LRRC7 include Dental Pulp Necrosis and Chromosome 3Q29 Deletion Syndrome. Among its related pathways are Innate Immune System. An important paralog of this gene is ERBIN.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J069566 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE CraniofacialAtlas | 625.3 | +0.7 | 667 | 4 | TEAD4 IKZF1 LARP7 PRDM1 PHF21A ZSCAN4 POLR2A EZH2 ZNF600 NRF1 | LRRC7 SGO1P1 lnc-LRRC40-6 LRRC40 | |
GH01J069919 | Promoter | 0.6 | EPDnew | 600 | +351.4 | 351405 | 0.1 | MGA ZBTB40 ZBTB33 ZFX | PIN1P1 lnc-SRSF11-2 LRRC7 piR-61580-031 LRRC40 | |
GH01J069539 | Enhancer | 1 | Ensembl ENCODE | 22 | -28.3 | -28307 | 1.6 | LEF1 IKZF1 DDX20 PKNOX1 MTA1 BRD9 ZNF24 DPF2 HDAC1 SOX6 | LRRC7 SRSF11 piR-40476-006 ENSG00000287453 LOC105378789 | |
GH01J070042 | Enhancer | 1.1 | FANTOM5 Ensembl | 8 | +474.1 | 474079 | 2.4 | LEF1 IKZF1 JUND PKNOX1 NR2C1 ZNF24 DPF2 SOX6 FOXJ2 GATAD2B | LRRC7-AS1 RF00017-243 LRRC7 CTH LRRC40 | |
GH01J069522 | Enhancer | 0.6 | Ensembl ENCODE | 13.7 | -44.3 | -44321 | 1.6 | CEBPB BHLHE40 MAFK NR2F6 IKZF1 | LRRC7 piR-40476-006 HSALNG0004349 LOC105378789 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 12390249 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005813 | centrosome | IDA | -- |
GO:0005829 | cytosol | IDA,TAS | -- |
GO:0005886 | plasma membrane | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0009790 | embryo development | IBA | 21873635 |
GO:0010976 | positive regulation of neuron projection development | IBA | 21873635 |
GO:0043113 | receptor clustering | IBA | 21873635 |
GO:0043312 | neutrophil degranulation | TAS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - |
ExUns: | 26 | ^ | 27 |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LRRC7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LRRC7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LRRC7 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LRRC7 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lrrc7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lrrc7 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | LRRC7 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LRRC7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LRRC7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lrrc7 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lrrc7 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Lap1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SOG2 33 |
|
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1135401780 | Uncertain Significance: Intellectual disability | 70,039,454(+) | T/G | NONSENSE | |
VAR_035715 | A breast cancer sample | p.Leu235Met | |||
rs12069888 | - | p.His1054Tyr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv18n27 | CNV | loss | 19166990 |
dgv305n54 | CNV | loss | 21841781 |
dgv6e215 | CNV | deletion | 23714750 |
esv1056018 | CNV | insertion | 17803354 |
esv1094257 | CNV | insertion | 17803354 |
esv2617051 | CNV | deletion | 19546169 |
esv2749586 | CNV | deletion | 23290073 |
esv3305104 | CNV | mobile element insertion | 20981092 |
esv3382626 | CNV | duplication | 20981092 |
esv3383107 | CNV | insertion | 20981092 |
esv3448225 | CNV | insertion | 20981092 |
esv3452085 | CNV | duplication | 20981092 |
esv3586344 | CNV | loss | 21293372 |
esv3586345 | CNV | loss | 21293372 |
esv3586346 | CNV | gain | 21293372 |
esv3586348 | CNV | gain | 21293372 |
nsv1110662 | CNV | insertion | 24896259 |
nsv1133864 | CNV | deletion | 24896259 |
nsv1142060 | CNV | tandem duplication | 24896259 |
nsv1151258 | CNV | duplication | 26484159 |
nsv461784 | CNV | loss | 19166990 |
nsv512742 | CNV | insertion | 21212237 |
nsv521307 | CNV | loss | 19592680 |
nsv525370 | CNV | loss | 19592680 |
nsv526839 | CNV | gain | 19592680 |
nsv546452 | CNV | loss | 21841781 |
nsv954734 | CNV | insertion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dental pulp necrosis |
|
|
chromosome 3q29 deletion syndrome |
|
|
cri-du-chat syndrome |
|
|
hypomelanosis of ito |
|
|
trichorhinophalangeal syndrome, type ii |
|
|