Aliases for LRRC63 Gene

Aliases for LRRC63 Gene

  • Leucine Rich Repeat Containing 63 2 3 5
  • Leucine-Rich Repeat-Containing Protein 63 3 4

External Ids for LRRC63 Gene

Previous GeneCards Identifiers for LRRC63 Gene

  • GC13P045686
  • GC13P046786

Summaries for LRRC63 Gene

GeneCards Summary for LRRC63 Gene

LRRC63 (Leucine Rich Repeat Containing 63) is a Protein Coding gene. Diseases associated with LRRC63 include Duodenal Somatostatinoma.

Additional gene information for LRRC63 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC63 Gene

Genomics for LRRC63 Gene

GeneHancer (GH) Regulatory Elements for LRRC63 Gene

Promoters and enhancers for LRRC63 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J046209 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509 -0.6 -610 3 NRF1 ZBTB26 RFX1 KLF7 MYC POLR2A MXI1 ZNF341 HCFC1 NCOR1 LRRC63 LCP1 LOC105370192
GH13J046163 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.6 -37.1 -37115 21.8 ZBTB40 CTCF SIN3A EP300 ZIC2 POLR2A AFF1 RELA MEF2C TOE1 LCP1 ERICH6B RNU2-6P RUBCNL LRRC63 TPT1-AS1 ZC3H13 piR-34822-077 lnc-CPB2-2 lnc-CPB2-3
GH13J046198 Enhancer 0.6 ENCODE dbSUPER 7.2 -14.2 -14190 0.2 ESRRA FOS EZH2 GATA3 CBFA2T3 RNU2-6P LRRC63 LCP1 LOC105370192
GH13J046199 Enhancer 0.6 ENCODE dbSUPER 5.3 -11.8 -11751 1.5 SPI1 MEIS2 ZZZ3 NFIC ZNF596 SREBF1 RNU2-6P LRRC63 LCP1 LOC105370192
GH13J046194 Enhancer 0.3 ENCODE dbSUPER 7.1 -16.7 -16704 1.1 RNU2-6P LRRC63 LOC105370192 LCP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC63 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC63

Top Transcription factor binding sites by QIAGEN in the LRRC63 gene promoter:
  • AML1a
  • Bach1
  • Cdc5
  • HNF-4alpha1
  • HNF-4alpha2
  • Lmo2
  • NF-E2
  • NF-E2 p45
  • STAT1alpha
  • STAT1beta

Genomic Locations for LRRC63 Gene

Genomic Locations for LRRC63 Gene
chr13:46,211,911-46,277,366
(GRCh38/hg38)
Size:
65,456 bases
Orientation:
Plus strand
chr13:46,786,083-46,858,181
(GRCh37/hg19)
Size:
72,099 bases
Orientation:
Plus strand

Genomic View for LRRC63 Gene

Genes around LRRC63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC63 Gene

Proteins for LRRC63 Gene

  • Protein details for LRRC63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05C16-LRC63_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 63
    Protein Accession:
    Q05C16
    Secondary Accessions:
    • Q5TBN0

    Protein attributes for LRRC63 Gene

    Size:
    580 amino acids
    Molecular mass:
    66309 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30276.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for LRRC63 Gene

Post-translational modifications for LRRC63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC63 Gene

Domains & Families for LRRC63 Gene

Gene Families for LRRC63 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC63 Gene

Suggested Antigen Peptide Sequences for LRRC63 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 63 (LRC63_HUMAN)
genes like me logo Genes that share domains with LRRC63: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC63 Gene

Function for LRRC63 Gene

Phenotypes From GWAS Catalog for LRRC63 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC63 Gene

Localization for LRRC63 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC63 gene
Compartment Confidence
golgi apparatus 2
mitochondrion 1
nucleus 1
cytosol 1
plasma membrane 0
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC63 Gene

Pathways & Interactions for LRRC63 Gene

PathCards logo

SuperPathways for LRRC63 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC63 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC63 Gene

Drugs & Compounds for LRRC63 Gene

No Compound Related Data Available

Transcripts for LRRC63 Gene

mRNA/cDNA for LRRC63 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC63 Gene

No ASD Table

Relevant External Links for LRRC63 Gene

GeneLoc Exon Structure for
LRRC63

Expression for LRRC63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC63 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.1), Brain - Substantia nigra (x7.2), and Testis (x6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC63 Gene



Protein tissue co-expression partners for LRRC63 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC63

SOURCE GeneReport for Unigene cluster for LRRC63 Gene:

Hs.267765
genes like me logo Genes that share expression patterns with LRRC63: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC63 Gene

Orthologs for LRRC63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC63 31 30
  • 98.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC63 31 30
  • 77.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC63 31 30
  • 75.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc63 17 31 30
  • 67.86 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc63 30
  • 66.61 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC63 31
  • 28 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC63 31
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC63 31
  • 42 (a)
OneToOne
Species where no ortholog for LRRC63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC63 Gene

ENSEMBL:
Gene Tree for LRRC63 (if available)
TreeFam:
Gene Tree for LRRC63 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC63: view image

Paralogs for LRRC63 Gene

(2) SIMAP similar genes for LRRC63 Gene using alignment to 3 proteins:

  • LRC63_HUMAN
  • J3KQU2_HUMAN
  • M0QXR7_HUMAN
genes like me logo Genes that share paralogs with LRRC63: view

No data available for Paralogs for LRRC63 Gene

Variants for LRRC63 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC63 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs12865423 - p.Lys281Arg
rs12865424 - p.Thr282Ala
rs6561303 - p.Met206Val
rs7338697 - p.Met137Val

Additional dbSNP identifiers (rs#s) for LRRC63 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC63 Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073
esv2670611 CNV deletion 23128226
esv3355783 CNV insertion 20981092
esv3365760 CNV duplication 20981092
esv3427293 CNV insertion 20981092
esv3631978 CNV loss 21293372
esv3631980 CNV loss 21293372
esv3631981 CNV loss 21293372
nsv1051215 CNV gain 25217958
nsv1122815 CNV deletion 24896259
nsv455876 CNV gain 19166990
nsv477482 CNV novel sequence insertion 20440878
nsv561581 CNV gain 21841781

Variation tolerance for LRRC63 Gene

Gene Damage Index Score: 5.36; 70.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC63 Gene

Disorders for LRRC63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC63 Gene - From: DISEASES

Disorder Aliases PubMed IDs
duodenal somatostatinoma
  • duodenal delta cell somatostatin producing tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC63

genes like me logo Genes that share disorders with LRRC63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC63 Gene

Publications for LRRC63 Gene

  1. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PMID: 17903304) Larson MG … Levy D (BMC medical genetics 2007) 3 41 54
  2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for LRRC63 Gene

Sources for LRRC63 Gene