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Aliases for LRRC61 Gene

Aliases for LRRC61 Gene

  • Leucine Rich Repeat Containing 61 2 3 5
  • Leucine-Rich Repeat-Containing Protein 61 3
  • HSPC295 3

External Ids for LRRC61 Gene

Previous GeneCards Identifiers for LRRC61 Gene

  • GC07P149651
  • GC07P150019
  • GC07P143836

Summaries for LRRC61 Gene

GeneCards Summary for LRRC61 Gene

LRRC61 (Leucine Rich Repeat Containing 61) is a Protein Coding gene.

Additional gene information for LRRC61 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC61 Gene

Genomics for LRRC61 Gene

GeneHancer (GH) Regulatory Elements for LRRC61 Gene

Promoters and enhancers for LRRC61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J150319 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 694.3 +0.4 397 6.6 MLX DMAP1 IRF4 YY1 E2F8 SP3 MEF2D GLIS1 NBN NR2C1 LRRC61 ACTR3C GC07P150324 ENSG00000244151 ZNF767P ZNF777 ZNF775 LOC105375564 ZNF862 ZNF746
GH07J150339 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 33.4 +18.4 18367 2.9 ELF3 PKNOX1 ARID4B SIN3A RAD21 RARA YY1 EGR1 FOS CREM RARRES2 ENSG00000261305 LRRC61 ACTR3C LOC105375560
GH07J150317 Enhancer 1.3 Ensembl ENCODE dbSUPER 36.7 -4.4 -4433 1.2 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 E2F8 ZFP91 ATF7 LRRC61 RARRES2 ZNF775 LOC105375564 ACTR3C GC07P150294
GH07J150305 Enhancer 1.1 ENCODE dbSUPER 40.1 -17.1 -17115 1 HDAC1 HDGF ATF1 ARNT NFRKB FEZF1 EGR1 ATF7 SMARCA5 ZBTB2 LRRC61 RARRES2 ZNF775 LOC105375564 GC07P150294 ACTR3C
GH07J150311 Enhancer 1.2 ENCODE dbSUPER 35 -9.5 -9464 2.7 HDGF PKNOX1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 E2F8 ARID2 LRRC61 RARRES2 ZNF775 LOC105375564 AOC1 ACTR3C GC07P150294
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC61 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC61 gene promoter:
  • Pax-4a
  • RFX1
  • Evi-1
  • HSF1short
  • HSF1 (long)
  • FOXO3b
  • FOXO3a
  • FOXO3
  • Sox5
  • RREB-1

Genomic Locations for LRRC61 Gene

Genomic Locations for LRRC61 Gene
chr7:150,322,639-150,338,156
(GRCh38/hg38)
Size:
15,518 bases
Orientation:
Plus strand
chr7:150,019,728-150,035,245
(GRCh37/hg19)
Size:
15,518 bases
Orientation:
Plus strand

Genomic View for LRRC61 Gene

Genes around LRRC61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC61 Gene

Proteins for LRRC61 Gene

  • Protein details for LRRC61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV99-LRC61_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 61
    Protein Accession:
    Q9BV99
    Secondary Accessions:
    • B3KUW0
    • D3DWY8

    Protein attributes for LRRC61 Gene

    Size:
    259 amino acids
    Molecular mass:
    28014 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC61 Gene

Post-translational modifications for LRRC61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC61 Gene

No data available for DME Specific Peptides for LRRC61 Gene

Domains & Families for LRRC61 Gene

Gene Families for LRRC61 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC61 Gene

Suggested Antigen Peptide Sequences for LRRC61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC61: view

No data available for UniProtKB/Swiss-Prot for LRRC61 Gene

Function for LRRC61 Gene

Phenotypes From GWAS Catalog for LRRC61 Gene

genes like me logo Genes that share phenotypes with LRRC61: view

Animal Model Products

miRNA for LRRC61 Gene

miRTarBase miRNAs that target LRRC61

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC61 Gene

Localization for LRRC61 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC61 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC61 Gene

Pathways & Interactions for LRRC61 Gene

SuperPathways for LRRC61 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC61 Gene

Drugs & Compounds for LRRC61 Gene

No Compound Related Data Available

Transcripts for LRRC61 Gene

Unigene Clusters for LRRC61 Gene

Leucine rich repeat containing 61:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC61 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for LRRC61 Gene

GeneLoc Exon Structure for
LRRC61
ECgene alternative splicing isoforms for
LRRC61

Expression for LRRC61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC61 Gene

This gene is overexpressed in Adrenal Gland (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of LRRC61 Gene:

LRRC61

SOURCE GeneReport for Unigene cluster for LRRC61 Gene:

Hs.647119

Evidence on tissue expression from TISSUES for LRRC61 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with LRRC61: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC61 Gene

Orthologs for LRRC61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC61 34 33
  • 99.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC61 33
  • 85.07 (n)
mouse
(Mus musculus)
Mammalia Lrrc61 16 34 33
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc61 33
  • 83.53 (n)
cow
(Bos Taurus)
Mammalia LRRC61 34 33
  • 82.88 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC61 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC61 33
  • 70.69 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc61 33
  • 61.68 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc61 33
  • 53.98 (n)
LRRC61 34
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for LRRC61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC61 Gene

ENSEMBL:
Gene Tree for LRRC61 (if available)
TreeFam:
Gene Tree for LRRC61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC61: view image

Paralogs for LRRC61 Gene

No data available for Paralogs for LRRC61 Gene

Variants for LRRC61 Gene

Sequence variations from dbSNP and Humsavar for LRRC61 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000063409 -- 150,324,086(+) G/T intron_variant
rs1000076312 -- 150,330,182(+) C/T intron_variant
rs1000325369 -- 150,335,247(+) T/C intron_variant
rs1000415450 -- 150,324,190(+) G/A intron_variant
rs1000557839 -- 150,333,397(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC61 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
dgv435n21 CNV loss 19592680
nsv1015582 CNV gain 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv508490 CNV deletion 20534489
nsv521407 CNV loss 19592680
nsv608990 CNV gain 21841781
nsv951645 CNV deletion 24416366

Variation tolerance for LRRC61 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC61 Gene

Disorders for LRRC61 Gene

Additional Disease Information for LRRC61

No disorders were found for LRRC61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC61 Gene

Publications for LRRC61 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58

Products for LRRC61 Gene

Sources for LRRC61 Gene

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