Aliases for LRRC59 Gene

Aliases for LRRC59 Gene

  • Leucine Rich Repeat Containing 59 2 3 5
  • Leucine-Rich Repeat-Containing Protein 59 3 4
  • Ribosome-Binding Protein P34 3 4
  • PRO1855 2 3
  • P34 3 4
  • FLJ21675 2
  • LRRC59 5

External Ids for LRRC59 Gene

Previous GeneCards Identifiers for LRRC59 Gene

  • GC17M045814
  • GC17M048458
  • GC17M043826

Summaries for LRRC59 Gene

GeneCards Summary for LRRC59 Gene

LRRC59 (Leucine Rich Repeat Containing 59) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for LRRC59 Gene

  • Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC59 Gene

Genomics for LRRC59 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC59 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC59 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC59

Top Transcription factor binding sites by QIAGEN in the LRRC59 gene promoter:
  • ATF-2
  • CRE-BP1
  • ER-alpha
  • Evi-1
  • Gfi-1
  • HNF-4alpha1
  • HNF-4alpha2
  • IRF-1
  • LCR-F1
  • YY1

Genomic Locations for LRRC59 Gene

Latest Assembly
chr17:50,375,059-50,397,523
(GRCh38/hg38)
Size:
22,465 bases
Orientation:
Minus strand

Previous Assembly
chr17:48,458,599-48,474,884
(GRCh37/hg19 by Entrez Gene)
Size:
16,286 bases
Orientation:
Minus strand

chr17:48,452,420-48,474,914
(GRCh37/hg19 by Ensembl)
Size:
22,495 bases
Orientation:
Minus strand

Genomic View for LRRC59 Gene

Genes around LRRC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC59 Gene

Proteins for LRRC59 Gene

  • Protein details for LRRC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AG4-LRC59_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 59
    Protein Accession:
    Q96AG4
    Secondary Accessions:
    • B2RE83
    • D3DTX8
    • Q9P189

    Protein attributes for LRRC59 Gene

    Size:
    307 amino acids
    Molecular mass:
    34930 Da
    Quaternary structure:
    • Can form homodimers. Interacts with SGO1. Interacts with FGF1.
    SequenceCaution:
    • Sequence=AAF69611.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG38180.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for LRRC59 Gene

Post-translational modifications for LRRC59 Gene

  • Ubiquitination at Lys40, Lys66, Lys73, Lys111, and Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC59 Gene

Antibodies for research

  • Abcam antibodies for LRRC59
  • Boster Bio Antibodies for LRRC59

No data available for DME Specific Peptides for LRRC59 Gene

Domains & Families for LRRC59 Gene

Gene Families for LRRC59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRRC59 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature

Suggested Antigen Peptide Sequences for LRRC59 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 59 (LRC59_HUMAN)
genes like me logo Genes that share domains with LRRC59: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC59 Gene

Function for LRRC59 Gene

Molecular function for LRRC59 Gene

UniProtKB/Swiss-Prot Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Phenotypes From GWAS Catalog for LRRC59 Gene

Gene Ontology (GO) - Molecular Function for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 32296183
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with LRRC59: view
genes like me logo Genes that share phenotypes with LRRC59: view

Animal Models for research

  • Taconic Biosciences Mouse Models for LRRC59

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC59

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC59 Gene

Localization for LRRC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC59 Gene

Microsome membrane. Single-pass type II membrane protein. Endoplasmic reticulum membrane. Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC59 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
mitochondrion 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with LRRC59: view

Pathways & Interactions for LRRC59 Gene

PathCards logo

SuperPathways for LRRC59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
GO:0046579 positive regulation of Ras protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with LRRC59: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC59 Gene

Drugs & Compounds for LRRC59 Gene

No Compound Related Data Available

Transcripts for LRRC59 Gene

mRNA/cDNA for LRRC59 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC59

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC59 Gene

No ASD Table

Relevant External Links for LRRC59 Gene

GeneLoc Exon Structure for
LRRC59

Expression for LRRC59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC59 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC59 Gene



Protein tissue co-expression partners for LRRC59 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC59

SOURCE GeneReport for Unigene cluster for LRRC59 Gene:

Hs.370927

mRNA Expression by UniProt/SwissProt for LRRC59 Gene:

Q96AG4-LRC59_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for LRRC59 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Skin(3.6)
  • Kidney(3)
  • Lung(3)
  • Intestine(2.9)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with LRRC59: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC59 Gene

Orthologs for LRRC59 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC59 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC59 29 30
  • 99.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC59 29 30
  • 92.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRC59 29 30
  • 89.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc59 29
  • 89.79 (n)
Mouse
(Mus musculus)
Mammalia Lrrc59 29 16 30
  • 89.58 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LRRC59 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRC59 29 30
  • 70.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC59 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc59 29
  • 61.2 (n)
Str.6358 29
Zebrafish
(Danio rerio)
Actinopterygii lrrc59 29 30
  • 61.47 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG3408 30
  • 28 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F56A8.3 29 30
  • 48.38 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 45 (a)
OneToOne
Species where no ortholog for LRRC59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LRRC59 Gene

ENSEMBL:
Gene Tree for LRRC59 (if available)
TreeFam:
Gene Tree for LRRC59 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC59: view image
Alliance of Genome Resources:
Additional Orthologs for LRRC59

Paralogs for LRRC59 Gene

Pseudogenes.org Pseudogenes for LRRC59 Gene

genes like me logo Genes that share paralogs with LRRC59: view

No data available for Paralogs for LRRC59 Gene

Variants for LRRC59 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRC59 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRC59 Gene

Variant ID Type Subtype PubMed ID
nsv2080 CNV deletion 18451855
nsv833475 CNV loss 17160897
nsv833476 CNV loss 17160897
nsv960122 CNV duplication 23825009

Variation tolerance for LRRC59 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC59
Leiden Open Variation Database (LOVD)
LRRC59

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC59 Gene

Disorders for LRRC59 Gene

Additional Disease Information for LRRC59

No disorders were found for LRRC59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC59 Gene

Publications for LRRC59 Gene

  1. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1. (PMID: 22321063) Zhen Y … Wiedlocha A (Traffic (Copenhagen, Denmark) 2012) 3 4
  2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for LRRC59 Gene

Sources for LRRC59 Gene