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Aliases for LRRC58 Gene

Aliases for LRRC58 Gene

  • Leucine Rich Repeat Containing 58 2 3 5

External Ids for LRRC58 Gene

Previous GeneCards Identifiers for LRRC58 Gene

  • GC03M121532
  • GC03M120043
  • GC03M117419

Summaries for LRRC58 Gene

GeneCards Summary for LRRC58 Gene

LRRC58 (Leucine Rich Repeat Containing 58) is a Protein Coding gene. An important paralog of this gene is PIDD1.

Additional gene information for LRRC58 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC58 Gene

Genomics for LRRC58 Gene

GeneHancer (GH) Regulatory Elements for LRRC58 Gene

Promoters and enhancers for LRRC58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I120347 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.1 -66 3.4 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC100130701 LRRC58 GPR156 TMEM39A MAATS1 LOC442087
GH03I120467 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.8 -121.7 -121669 6.2 NCOA3 PKNOX1 JUN NEUROD1 CTBP1 GATA3 RCOR1 FOS MAFK TCF7L2 LRRC58 RPL34P9 ADPRH ENSG00000240774 FSTL1
GH03I120416 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.3 -70.0 -70015 6.7 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 ZNF143 FOS ATF7 DEK GPR156 FSTL1 LOC100130701 LRRC58 MIR198
GH03I119702 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 4.5 +646.3 646342 1 HDGF MXI1 NFIB NEUROD1 MAX SIN3A BMI1 ZBTB7B RAD21 YY1 MAATS1 LOC105374064 LRRC58
GH03I119699 Enhancer 1 Ensembl ENCODE 5.3 +648.6 648602 2 HDGF ELF3 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ATF7 ETV6 MAATS1 ENSG00000239994 LRRC58 PLA1A LOC105374064 PIR40954
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC58 gene promoter:

Genomic Locations for LRRC58 Gene

Genomic Locations for LRRC58 Gene
24,853 bases
Minus strand

Genomic View for LRRC58 Gene

Genes around LRRC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC58 Gene

Proteins for LRRC58 Gene

  • Protein details for LRRC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 58
    Protein Accession:

    Protein attributes for LRRC58 Gene

    371 amino acids
    Molecular mass:
    40586 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH13757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC58 Gene

Post-translational modifications for LRRC58 Gene

  • Ubiquitination at isoforms=111 and posLast=300300
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC58 Gene

Domains & Families for LRRC58 Gene

Gene Families for LRRC58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC58 Gene

Suggested Antigen Peptide Sequences for LRRC58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC58: view

No data available for UniProtKB/Swiss-Prot for LRRC58 Gene

Function for LRRC58 Gene

Phenotypes From GWAS Catalog for LRRC58 Gene

Phenotypes for LRRC58 Gene

genes like me logo Genes that share phenotypes with LRRC58: view

Animal Model Products

miRNA for LRRC58 Gene

miRTarBase miRNAs that target LRRC58

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC58 Gene

Localization for LRRC58 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC58 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC58 Gene

Pathways & Interactions for LRRC58 Gene

SuperPathways for LRRC58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC58 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC58 Gene

Drugs & Compounds for LRRC58 Gene

No Compound Related Data Available

Transcripts for LRRC58 Gene

mRNA/cDNA for LRRC58 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(212) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC58 Gene

Leucine rich repeat containing 58:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC58 Gene

No ASD Table

Relevant External Links for LRRC58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC58 Gene

Protein differential expression in normal tissues from HIPED for LRRC58 Gene

This gene is overexpressed in Adrenal (30.4), Gallbladder (10.3), and Pancreas (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC58 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC58 Gene:


SOURCE GeneReport for Unigene cluster for LRRC58 Gene:

genes like me logo Genes that share expression patterns with LRRC58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC58 Gene

Orthologs for LRRC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC58 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia LRRC58 33 34
  • 92.98 (n)
(Bos Taurus)
Mammalia LRRC58 33 34
  • 92 (n)
(Rattus norvegicus)
Mammalia Lrrc58 33
  • 89.53 (n)
(Mus musculus)
Mammalia Lrrc58 33 16 34
  • 89.07 (n)
(Ornithorhynchus anatinus)
Mammalia LRRC58 34
  • 84 (a)
(Monodelphis domestica)
Mammalia LRRC58 34
  • 82 (a)
(Gallus gallus)
Aves LRRC58 33 34
  • 76.84 (n)
(Anolis carolinensis)
Reptilia LRRC58 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc58 33
  • 66.09 (n)
Str.19464 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398462 33
(Danio rerio)
Actinopterygii lrrc58b 34
  • 61 (a)
LOC564300 33
  • 60.46 (n)
lrrc58a 34
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004458 33
  • 55.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32687 33 34
  • 52.91 (n)
(Caenorhabditis elegans)
Secernentea Y42G9A.3 33 34
  • 47.96 (n)
Species where no ortholog for LRRC58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC58 Gene

Gene Tree for LRRC58 (if available)
Gene Tree for LRRC58 (if available)

Paralogs for LRRC58 Gene

genes like me logo Genes that share paralogs with LRRC58: view

Variants for LRRC58 Gene

Sequence variations from dbSNP and Humsavar for LRRC58 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000054844 -- 120,345,514(-) T/C intron_variant
rs1000068428 -- 120,330,017(-) T/A/C 3_prime_UTR_variant
rs1000097103 -- 120,325,642(-) A/T 3_prime_UTR_variant
rs1000121522 -- 120,345,786(-) G/A intron_variant
rs1000308175 -- 120,332,887(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC58 Gene

Variant ID Type Subtype PubMed ID
nsv236293 CNV deletion 16902084
nsv3968 CNV deletion 18451855
nsv829698 CNV gain 17160897

Variation tolerance for LRRC58 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC58 Gene

Disorders for LRRC58 Gene

Additional Disease Information for LRRC58

No disorders were found for LRRC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC58 Gene

Publications for LRRC58 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 58
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  4. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin DJ … Visscher PM (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 58
  5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 58

Products for LRRC58 Gene

Sources for LRRC58 Gene

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