Aliases for LRRC58 Gene

Aliases for LRRC58 Gene

  • Leucine Rich Repeat Containing 58 2 3 5
  • Leucine-Rich Repeat-Containing Protein 58 3 4
  • LRRC58 5

External Ids for LRRC58 Gene

Previous GeneCards Identifiers for LRRC58 Gene

  • GC03M121532
  • GC03M120043
  • GC03M117419

Summaries for LRRC58 Gene

GeneCards Summary for LRRC58 Gene

LRRC58 (Leucine Rich Repeat Containing 58) is a Protein Coding gene. An important paralog of this gene is MFHAS1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC58 Gene

Genomics for LRRC58 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC58 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC58 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC58

Top Transcription factor binding sites by QIAGEN in the LRRC58 gene promoter:
  • AML1a
  • ATF6
  • ER-alpha
  • NF-1/L
  • Nkx2-5
  • Pax-2
  • Pax-2a
  • Pax-5
  • TBP
  • Zic3

Genomic Locations for LRRC58 Gene

Latest Assembly
chr3:120,324,509-120,349,354
(GRCh38/hg38)
Size:
24,846 bases
Orientation:
Minus strand

Previous Assembly
chr3:120,043,356-120,068,201
(GRCh37/hg19 by Entrez Gene)
Size:
24,846 bases
Orientation:
Minus strand

chr3:120,043,356-120,068,186
(GRCh37/hg19 by Ensembl)
Size:
24,831 bases
Orientation:
Minus strand

Genomic View for LRRC58 Gene

Genes around LRRC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC58 Gene

Proteins for LRRC58 Gene

  • Protein details for LRRC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CX6-LRC58_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 58
    Protein Accession:
    Q96CX6

    Protein attributes for LRRC58 Gene

    Size:
    371 amino acids
    Molecular mass:
    40586 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC58 Gene

Post-translational modifications for LRRC58 Gene

  • Ubiquitination at Lys111 and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC58 Gene

Domains & Families for LRRC58 Gene

Gene Families for LRRC58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC58 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature

Suggested Antigen Peptide Sequences for LRRC58 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 58 (LRC58_HUMAN)
genes like me logo Genes that share domains with LRRC58: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC58 Gene

Function for LRRC58 Gene

Phenotypes From GWAS Catalog for LRRC58 Gene

Gene Ontology (GO) - Molecular Function for LRRC58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC58: view
genes like me logo Genes that share phenotypes with LRRC58: view

miRNA for LRRC58 Gene

miRTarBase miRNAs that target LRRC58

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC58 Gene

Localization for LRRC58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC58 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC58 Gene

Pathways & Interactions for LRRC58 Gene

PathCards logo

SuperPathways for LRRC58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC58 Gene

Drugs & Compounds for LRRC58 Gene

No Compound Related Data Available

Transcripts for LRRC58 Gene

mRNA/cDNA for LRRC58 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC58

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC58 Gene

No ASD Table

Relevant External Links for LRRC58 Gene

GeneLoc Exon Structure for
LRRC58

Expression for LRRC58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC58 Gene

Protein differential expression in normal tissues from HIPED for LRRC58 Gene

This gene is overexpressed in Adrenal (30.4), Gallbladder (10.3), and Pancreas (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC58 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC58

SOURCE GeneReport for Unigene cluster for LRRC58 Gene:

Hs.518084
genes like me logo Genes that share expression patterns with LRRC58: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC58 Gene

Orthologs for LRRC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC58 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC58 29 30
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRC58 29 30
  • 92.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC58 29 30
  • 92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc58 29
  • 89.53 (n)
Mouse
(Mus musculus)
Mammalia Lrrc58 29 16 30
  • 89.07 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRRC58 30
  • 84 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LRRC58 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRC58 29 30
  • 76.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC58 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc58 29
  • 66.09 (n)
Str.19464 29
African clawed frog
(Xenopus laevis)
Amphibia LOC398462 29
Zebrafish
(Danio rerio)
Actinopterygii lrrc58b 30
  • 61 (a)
OneToMany
LOC564300 29
  • 60.46 (n)
lrrc58a 30
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004458 29
  • 55.72 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG32687 29 30
  • 52.91 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y42G9A.3 29 30
  • 47.96 (n)
OneToOne
Species where no ortholog for LRRC58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LRRC58 Gene

ENSEMBL:
Gene Tree for LRRC58 (if available)
TreeFam:
Gene Tree for LRRC58 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC58: view image
Alliance of Genome Resources:
Additional Orthologs for LRRC58

Paralogs for LRRC58 Gene

Variants for LRRC58 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRC58 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRC58 Gene

Variant ID Type Subtype PubMed ID
nsv236293 CNV deletion 16902084
nsv3968 CNV deletion 18451855
nsv829698 CNV gain 17160897

Variation tolerance for LRRC58 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC58
Leiden Open Variation Database (LOVD)
LRRC58

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC58 Gene

Disorders for LRRC58 Gene

Additional Disease Information for LRRC58

No disorders were found for LRRC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC58 Gene

Publications for LRRC58 Gene

  1. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. (PMID: 31253590) Hüttenhain R … Krogan NJ (Cell host & microbe 2019) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3
  5. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin DJ … Visscher PM (Proceedings of the National Academy of Sciences of the United States of America 2012) 3

Products for LRRC58 Gene

Sources for LRRC58 Gene