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Aliases for LRRC57 Gene

Aliases for LRRC57 Gene

  • Leucine Rich Repeat Containing 57 2 3 5
  • Leucine-Rich Repeat-Containing Protein 57 3

External Ids for LRRC57 Gene

Previous GeneCards Identifiers for LRRC57 Gene

  • GC15M040623
  • GC15M042836
  • GC15M019682

Summaries for LRRC57 Gene

GeneCards Summary for LRRC57 Gene

LRRC57 (Leucine Rich Repeat Containing 57) is a Protein Coding gene. An important paralog of this gene is PIDD1.

Gene Wiki entry for LRRC57 Gene

Additional gene information for LRRC57 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC57 Gene

Genomics for LRRC57 Gene

GeneHancer (GH) Regulatory Elements for LRRC57 Gene

Promoters and enhancers for LRRC57 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J042547 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 669.9 -0.2 -213 2.7 HDGF FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B LRRC57 HAUS2 GANC LOC105370795 VPS39 CDAN1 ADAL ENSG00000261822
GH15J042493 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 40.7 +53.5 53499 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 SNAP23 LRRC57 CDAN1 GANC ZSCAN29 HAUS2 MGA LCMT2 LOC105370795 VPS39
GH15J042490 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.8 +57.6 57568 2.5 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SNAP23 ZNF106 LRRC57 TMEM87A GANC ZSCAN29 CDAN1 MGA LCMT2 HAUS2
GH15J043328 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30 -781.4 -781382 3 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ADAL LCMT2 LRRC57 CDAN1 ZSCAN29 WDR76 UBR1 TP53BP1 MFAP1 RPS3AP47
GH15J043122 Promoter/Enhancer 1.4 Ensembl ENCODE 44.5 -574.3 -574261 1.7 PKNOX1 ATF1 SIN3A BRCA1 GLIS2 ATF7 MCM3 SP3 RXRA GTF2B TMEM62 LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC57 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC57 gene promoter:
  • HNF-4alpha1
  • c-Jun
  • JunD
  • JunB
  • Fra-1
  • FosB
  • c-Fos
  • AP-1
  • POU2F1
  • POU2F1a

Genomic Locations for LRRC57 Gene

Genomic Locations for LRRC57 Gene
20,361 bases
Minus strand
6,283 bases
Minus strand

Genomic View for LRRC57 Gene

Genes around LRRC57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC57 Gene

Proteins for LRRC57 Gene

  • Protein details for LRRC57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 57
    Protein Accession:
    Secondary Accessions:
    • Q7Z2Z6
    • Q8N1T6

    Protein attributes for LRRC57 Gene

    239 amino acids
    Molecular mass:
    26754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC57 Gene

Post-translational modifications for LRRC57 Gene

  • Ubiquitination at posLast=140140 and posLast=3535
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC57 Gene

No data available for DME Specific Peptides for LRRC57 Gene

Domains & Families for LRRC57 Gene

Gene Families for LRRC57 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC57 Gene

Suggested Antigen Peptide Sequences for LRRC57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC57: view

No data available for UniProtKB/Swiss-Prot for LRRC57 Gene

Function for LRRC57 Gene

Phenotypes From GWAS Catalog for LRRC57 Gene

genes like me logo Genes that share phenotypes with LRRC57: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC57 Gene

Localization for LRRC57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC57 Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC57 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with LRRC57: view

Pathways & Interactions for LRRC57 Gene

SuperPathways for LRRC57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC57 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC57 Gene

Drugs & Compounds for LRRC57 Gene

No Compound Related Data Available

Transcripts for LRRC57 Gene

mRNA/cDNA for LRRC57 Gene

Unigene Clusters for LRRC57 Gene

Leucine rich repeat containing 57:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for LRRC57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC57 Gene

Protein differential expression in normal tissues from HIPED for LRRC57 Gene

This gene is overexpressed in Brain (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC57 Gene

Protein tissue co-expression partners for LRRC57 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC57 Gene:


SOURCE GeneReport for Unigene cluster for LRRC57 Gene:


Evidence on tissue expression from TISSUES for LRRC57 Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LRRC57: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC57 Gene

Orthologs for LRRC57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRC57 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC57 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia LRRC57 34 33
  • 91.77 (n)
(Bos Taurus)
Mammalia LRRC57 34 33
  • 89.96 (n)
(Rattus norvegicus)
Mammalia Lrrc57 33
  • 89.26 (n)
(Mus musculus)
Mammalia Lrrc57 16 34 33
  • 88.98 (n)
(Monodelphis domestica)
Mammalia LRRC57 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC57 34
  • 82 (a)
(Gallus gallus)
Aves LRRC57 34 33
  • 74.93 (n)
(Anolis carolinensis)
Reptilia LRRC57 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc57 33
  • 69.47 (n)
(Danio rerio)
Actinopterygii lrrc57 34 33
  • 67.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3040 34 33
  • 55.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001491 33
  • 51.4 (n)
(Caenorhabditis elegans)
Secernentea ZK546.2 34 33
  • 48.01 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30105 33
  • 42.2 (n)
(Oryza sativa)
Liliopsida Os10g0456200 33
  • 41.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 10 (a)
Species where no ortholog for LRRC57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC57 Gene

Gene Tree for LRRC57 (if available)
Gene Tree for LRRC57 (if available)
Evolutionary constrained regions (ECRs) for LRRC57: view image

Paralogs for LRRC57 Gene

(11) SIMAP similar genes for LRRC57 Gene using alignment to 2 proteins:

  • H3BSW0_HUMAN Pseudogenes for LRRC57 Gene

genes like me logo Genes that share paralogs with LRRC57: view

Variants for LRRC57 Gene

Sequence variations from dbSNP and Humsavar for LRRC57 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000026125 -- 42,544,594(-) G/A intron_variant
rs1000033769 -- 42,547,765(-) A/C intron_variant
rs1000085531 -- 42,548,183(-) TTGTTGTTG/TTGTTG coding_sequence_variant, inframe_deletion
rs1000097704 -- 42,543,062(-) G/A 3_prime_UTR_variant, intron_variant
rs1000221779 -- 42,531,630(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC57 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV gain 19592680

Variation tolerance for LRRC57 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC57 Gene

Disorders for LRRC57 Gene

Additional Disease Information for LRRC57

No disorders were found for LRRC57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC57 Gene

Publications for LRRC57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for LRRC57 Gene

Sources for LRRC57 Gene

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