Aliases for LRRC57 Gene

Aliases for LRRC57 Gene

  • Leucine Rich Repeat Containing 57 2 3 5
  • Leucine-Rich Repeat-Containing Protein 57 3 4
  • FLJ36812 2
  • LRRC57 5

External Ids for LRRC57 Gene

Previous GeneCards Identifiers for LRRC57 Gene

  • GC15M040623
  • GC15M042836
  • GC15M019682

Summaries for LRRC57 Gene

GeneCards Summary for LRRC57 Gene

LRRC57 (Leucine Rich Repeat Containing 57) is a Protein Coding gene. An important paralog of this gene is ENSG00000285942.

Gene Wiki entry for LRRC57 Gene

Additional gene information for LRRC57 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC57 Gene

Genomics for LRRC57 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC57 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC57 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC57

Top Transcription factor binding sites by QIAGEN in the LRRC57 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • HNF-4alpha1
  • JunB
  • JunD
  • POU2F1
  • POU2F1a

Genomic Locations for LRRC57 Gene

Genomic Locations for LRRC57 Gene
chr15:42,528,332-42,548,802
(GRCh38/hg38)
Size:
20,471 bases
Orientation:
Minus strand
chr15:42,834,720-42,841,002
(GRCh37/hg19)
Size:
6,283 bases
Orientation:
Minus strand

Genomic View for LRRC57 Gene

Genes around LRRC57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC57 Gene

Proteins for LRRC57 Gene

  • Protein details for LRRC57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N7-LRC57_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 57
    Protein Accession:
    Q8N9N7
    Secondary Accessions:
    • Q7Z2Z6
    • Q8N1T6

    Protein attributes for LRRC57 Gene

    Size:
    239 amino acids
    Molecular mass:
    26754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC57 Gene

Post-translational modifications for LRRC57 Gene

  • Ubiquitination at Lys35 and Lys140
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC57 Gene

No data available for DME Specific Peptides for LRRC57 Gene

Domains & Families for LRRC57 Gene

Gene Families for LRRC57 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC57 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC57 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 57 (LRC57_HUMAN)
genes like me logo Genes that share domains with LRRC57: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC57 Gene

Function for LRRC57 Gene

Phenotypes From GWAS Catalog for LRRC57 Gene

Gene Ontology (GO) - Molecular Function for LRRC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC57: view
genes like me logo Genes that share phenotypes with LRRC57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC57

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC57 Gene

Localization for LRRC57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC57 Gene

Membrane. Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC57 gene
Compartment Confidence
extracellular 4
cytosol 3
mitochondrion 2
nucleus 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with LRRC57: view

Pathways & Interactions for LRRC57 Gene

PathCards logo

SuperPathways for LRRC57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC57 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC57 Gene

Drugs & Compounds for LRRC57 Gene

No Compound Related Data Available

Transcripts for LRRC57 Gene

mRNA/cDNA for LRRC57 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC57

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for LRRC57 Gene

GeneLoc Exon Structure for
LRRC57

Expression for LRRC57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC57 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for LRRC57 Gene

This gene is overexpressed in Brain (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC57 Gene



Protein tissue co-expression partners for LRRC57 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC57

SOURCE GeneReport for Unigene cluster for LRRC57 Gene:

Hs.234681

Evidence on tissue expression from TISSUES for LRRC57 Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LRRC57: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC57 Gene

Orthologs for LRRC57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRC57 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC57 30 31
  • 99.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRC57 30 31
  • 91.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC57 30 31
  • 89.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc57 30
  • 89.26 (n)
Mouse
(Mus musculus)
Mammalia Lrrc57 30 17 31
  • 88.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LRRC57 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRRC57 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRC57 30 31
  • 74.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC57 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc57 30
  • 69.47 (n)
Zebrafish
(Danio rerio)
Actinopterygii lrrc57 30 31
  • 67.23 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG3040 30 31
  • 55.27 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001491 30
  • 51.4 (n)
Worm
(Caenorhabditis elegans)
Secernentea ZK546.2 30 31
  • 48.01 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G30105 30
  • 42.2 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0456200 30
  • 41.32 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 10 (a)
ManyToMany
Species where no ortholog for LRRC57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LRRC57 Gene

ENSEMBL:
Gene Tree for LRRC57 (if available)
TreeFam:
Gene Tree for LRRC57 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC57: view image

Paralogs for LRRC57 Gene

Paralogs for LRRC57 Gene

(11) SIMAP similar genes for LRRC57 Gene using alignment to 2 proteins:

  • LRC57_HUMAN
  • H3BSW0_HUMAN

Pseudogenes.org Pseudogenes for LRRC57 Gene

genes like me logo Genes that share paralogs with LRRC57: view

Variants for LRRC57 Gene

Additional dbSNP identifiers (rs#s) for LRRC57 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC57 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV gain 19592680

Variation tolerance for LRRC57 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC57 Gene

Disorders for LRRC57 Gene

No disorders were found for LRRC57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC57 Gene

Publications for LRRC57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
  4. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  5. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3

Products for LRRC57 Gene

  • Signalway Proteins for LRRC57

Sources for LRRC57 Gene