Aliases for LRRC55 Gene

Aliases for LRRC55 Gene

  • Leucine Rich Repeat Containing 55 2 3 5
  • Leucine-Rich Repeat-Containing Protein 55 3 4
  • BK Channel Auxiliary Gamma Subunit LRRC55 3 4
  • BK Channel Auxilliary Gamma Snit LRRC55 3

External Ids for LRRC55 Gene

Previous GeneCards Identifiers for LRRC55 Gene

  • GC11P056706
  • GC11P056949
  • GC11P053298

Summaries for LRRC55 Gene

GeneCards Summary for LRRC55 Gene

LRRC55 (Leucine Rich Repeat Containing 55) is a Protein Coding gene. An important paralog of this gene is SLIT2.

UniProtKB/Swiss-Prot Summary for LRRC55 Gene

  • Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.

Additional gene information for LRRC55 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC55 Gene

Genomics for LRRC55 Gene

GeneHancer (GH) Regulatory Elements for LRRC55 Gene

Promoters and enhancers for LRRC55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057180 Promoter/Enhancer 0.6 ENCODE CraniofacialAtlas 750.6 -1.6 -1645 0.4 POLR2A LRRC55 lnc-LRRC55-1 APLNR
GH11J057179 Enhancer 0.2 ENCODE 750.6 -1.9 -1915 0.2 LRRC55 lnc-LRRC55-1 piR-36588-065
GH11J057334 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 8.8 +154.1 154075 3.2 ZNF24 SP1 ZBTB40 POLR2A HCFC1 MYC ELF1 MAX ZNF148 ZBTB33 SSRP1 P2RX3 CLP1 TNKS1BP1 ZDHHC5 LRRC55 RF01210-063
GH11J057155 Enhancer 1 Ensembl ENCODE dbSUPER 18.6 -25.3 -25276 2.7 SMARCE1 ELF1 TEAD4 SMARCA4 IKZF1 HDAC1 LEF1 SOX6 FOSL1 RCOR1 LRRC55 APLNR PRG2 NONHSAG008345.2 piR-57460-088
GH11J057202 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 16.1 +22.6 22554 4.6 SP1 RXRA NR2F2 RAD21 CTCF MAX APLNR LRRC55 UBE2L6 MG828485 piR-34163-002 MG828486 LOC105369309
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC55 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC55 gene promoter:
  • Cdc5
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Pax-2
  • Pax-2b

Genomic Locations for LRRC55 Gene

Genomic Locations for LRRC55 Gene
chr11:57,181,747-57,191,717
(GRCh38/hg38)
Size:
9,971 bases
Orientation:
Plus strand
chr11:56,949,221-56,959,191
(GRCh37/hg19)
Size:
9,971 bases
Orientation:
Plus strand

Genomic View for LRRC55 Gene

Genes around LRRC55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC55 Gene

Proteins for LRRC55 Gene

  • Protein details for LRRC55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSA7-LRC55_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 55
    Protein Accession:
    Q6ZSA7
    Secondary Accessions:
    • A7E2U7
    • B2RN81

    Protein attributes for LRRC55 Gene

    Size:
    298 amino acids
    Molecular mass:
    33009 Da
    Quaternary structure:
    • Interacts with KCNMA1.
    SequenceCaution:
    • Sequence=AAI36738.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI36740.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI50573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC87047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LRRC55 Gene

Post-translational modifications for LRRC55 Gene

No Post-translational modifications

Other Protein References for LRRC55 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC55 Gene

Domains & Families for LRRC55 Gene

Gene Families for LRRC55 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for LRRC55 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 55 (LRC55_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZSA7

UniProtKB/Swiss-Prot:

LRC55_HUMAN :
  • The transmembrane domain is necessary for interaction with KCNMA1.
Domain:
  • The transmembrane domain is necessary for interaction with KCNMA1.
genes like me logo Genes that share domains with LRRC55: view

Function for LRRC55 Gene

Molecular function for LRRC55 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.

Phenotypes From GWAS Catalog for LRRC55 Gene

Gene Ontology (GO) - Molecular Function for LRRC55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IDA 22547800
GO:0005515 protein binding IEA --
GO:0044325 ion channel binding IPI 22547800
GO:0099104 potassium channel activator activity IDA 22547800
genes like me logo Genes that share ontologies with LRRC55: view
genes like me logo Genes that share phenotypes with LRRC55: view

Animal Model Products

CRISPR Products

miRNA for LRRC55 Gene

miRTarBase miRNAs that target LRRC55

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC55 Gene

Localization for LRRC55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC55 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC55 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 0
mitochondrion 0
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for LRRC55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane ISS 22547800
GO:0008076 voltage-gated potassium channel complex IDA 22547800
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC55: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRRC55 Gene

Pathways & Interactions for LRRC55 Gene

PathCards logo

SuperPathways for LRRC55 Gene

No Data Available

Interacting Proteins for LRRC55 Gene

Gene Ontology (GO) - Biological Process for LRRC55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0071805 potassium ion transmembrane transport IDA 22547800
GO:1903818 positive regulation of voltage-gated potassium channel activity IDA 22547800
genes like me logo Genes that share ontologies with LRRC55: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC55 Gene

Drugs & Compounds for LRRC55 Gene

No Compound Related Data Available

Transcripts for LRRC55 Gene

mRNA/cDNA for LRRC55 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC55 Gene

No ASD Table

Relevant External Links for LRRC55 Gene

GeneLoc Exon Structure for
LRRC55
ECgene alternative splicing isoforms for
LRRC55

Expression for LRRC55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC55 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC55 Gene

This gene is overexpressed in Brain - Hypothalamus (x7.9), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.1), Brain - Substantia nigra (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of LRRC55 Gene:

LRRC55

SOURCE GeneReport for Unigene cluster for LRRC55 Gene:

Hs.199853

mRNA Expression by UniProt/SwissProt for LRRC55 Gene:

Q6ZSA7-LRC55_HUMAN
Tissue specificity: Mainly expressed in brain.

Evidence on tissue expression from TISSUES for LRRC55 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with LRRC55: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC55 Gene

Orthologs for LRRC55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC55 33 32
  • 99.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC55 33 32
  • 89.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc55 17 33 32
  • 87.14 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC55 33
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc55 32
  • 86.71 (n)
cow
(Bos Taurus)
Mammalia LRRC55 33 32
  • 83.49 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC55 33
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC55 33 32
  • 75.35 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC55 33
  • 76 (a)
OneToOne
Species where no ortholog for LRRC55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC55 Gene

ENSEMBL:
Gene Tree for LRRC55 (if available)
TreeFam:
Gene Tree for LRRC55 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC55: view image

Paralogs for LRRC55 Gene

(1) SIMAP similar genes for LRRC55 Gene using alignment to 1 proteins:

  • LRC55_HUMAN
genes like me logo Genes that share paralogs with LRRC55: view

Variants for LRRC55 Gene

Sequence variations from dbSNP and Humsavar for LRRC55 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000425909 -- 57,182,792(+) T/C intron_variant
rs1000638071 -- 57,191,460(+) C/T 3_prime_UTR_variant
rs1001060060 -- 57,187,086(+) A/G intron_variant
rs1001092577 -- 57,185,887(+) A/T intron_variant
rs1001125180 -- 57,185,594(+) C/T intron_variant

Variation tolerance for LRRC55 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC55 Gene

Human Gene Mutation Database (HGMD)
LRRC55
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC55 Gene

Disorders for LRRC55 Gene

Additional Disease Information for LRRC55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRC55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC55 Gene

Publications for LRRC55 Gene

  1. BK potassium channel modulation by leucine-rich repeat-containing proteins. (PMID: 22547800) Yan J … Aldrich RW (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 4 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 56
  5. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits. (PMID: 26009545) Li Q … Yan J (The Journal of general physiology 2015) 3 56

Products for LRRC55 Gene

Sources for LRRC55 Gene