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Aliases for LRRC4C Gene

Aliases for LRRC4C Gene

  • Leucine Rich Repeat Containing 4C 2 3 5
  • Leucine-Rich Repeat-Containing Protein 4C 3 4
  • Netrin-G1 Ligand 3 4
  • NGL-1 3 4
  • NGL1 3 4
  • KIAA1580 4

External Ids for LRRC4C Gene

Previous GeneCards Identifiers for LRRC4C Gene

  • GC11M040093
  • GC11M039843

Summaries for LRRC4C Gene

Entrez Gene Summary for LRRC4C Gene

  • NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LRRC4C Gene

LRRC4C (Leucine Rich Repeat Containing 4C) is a Protein Coding gene. Diseases associated with LRRC4C include Extragonadal Seminoma and Chief Cell Adenoma. Among its related pathways are Axon guidance and Cell adhesion molecules (CAMs). An important paralog of this gene is LRRC4B.

UniProtKB/Swiss-Prot for LRRC4C Gene

Additional gene information for LRRC4C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC4C Gene

Genomics for LRRC4C Gene

GeneHancer (GH) Regulatory Elements for LRRC4C Gene

Promoters and enhancers for LRRC4C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J041460 Promoter 1 EPDnew Ensembl 600.7 +0.8 811 2 LRRC4C ENSG00000255132
GH11J041222 Promoter 0.5 EPDnew 600.1 +237.4 237363 0.1 LRRC4C GC11P041305 RNU6-365P
GH11J041497 Enhancer 0.6 Ensembl ENCODE 11.2 -38.3 -38289 3 SP1 CTCF RAD21 LRRC4C RPL9P23
GH11J041377 Enhancer 0.6 Ensembl 10.3 +82.2 82211 1.2 SP1 RXRA JUND ATF3 YY1 GABPA NR2F2 RAD21 HNF4A MAX LRRC4C GC11M041362 ENSG00000255132
GH11J041534 Enhancer 0.6 Ensembl ENCODE 10.6 -75.3 -75337 2.9 POLR2A POU5F1 RPL9P23 LRRC4C LINC02741
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC4C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC4C gene promoter:
  • ATF
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • Pax-4a
  • Pbx1a

Genomic Locations for LRRC4C Gene

Genomic Locations for LRRC4C Gene
1,350,275 bases
Minus strand
1,345,571 bases
Minus strand

Genomic View for LRRC4C Gene

Genes around LRRC4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC4C Gene

Proteins for LRRC4C Gene

  • Protein details for LRRC4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 4C
    Protein Accession:
    Secondary Accessions:
    • A8K0T1
    • Q7L0N3

    Protein attributes for LRRC4C Gene

    640 amino acids
    Molecular mass:
    71950 Da
    Quaternary structure:
    • Interacts with NTNG1 and WHRN.

    Three dimensional structures from OCA and Proteopedia for LRRC4C Gene

neXtProt entry for LRRC4C Gene

Post-translational modifications for LRRC4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC4C Gene

Domains & Families for LRRC4C Gene

Gene Families for LRRC4C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LRRC4C Gene

GenScript: Design optimal peptide antigens:
  • Netrin-G1 ligand (LRC4C_HUMAN)
  • Netrin-G1 ligand splice variant 4 (Q4JIV9_HUMAN)
  • Netrin-G1 ligand splice variant 3 (Q4JIW0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The LRR region is both necessary and sufficient for the interaction with NTNG1.
  • The LRR region is both necessary and sufficient for the interaction with NTNG1.
genes like me logo Genes that share domains with LRRC4C: view

Function for LRRC4C Gene

Molecular function for LRRC4C Gene

UniProtKB/Swiss-Prot Function:
May promote neurite outgrowth of developing thalamic neurons.

Phenotypes From GWAS Catalog for LRRC4C Gene

Gene Ontology (GO) - Molecular Function for LRRC4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14595443
GO:0050839 cell adhesion molecule binding IPI 23986473
GO:0098632 cell-cell adhesion mediator activity IGI 23986473
genes like me logo Genes that share ontologies with LRRC4C: view
genes like me logo Genes that share phenotypes with LRRC4C: view

Animal Models for LRRC4C Gene

MGI Knock Outs for LRRC4C:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC4C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC4C

Clone Products

  • Applied Biological Materials (abm): Clones for LRRC4C - Now 50% OFF >
  • * LRRC4C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LRRC4C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC4C Gene

Localization for LRRC4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC4C Gene

Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC4C gene
Compartment Confidence
plasma membrane 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,IDA 14595443
GO:0016021 integral component of membrane NAS 14595443
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with LRRC4C: view

Pathways & Interactions for LRRC4C Gene

PathCards logo

SuperPathways for LRRC4C Gene

genes like me logo Genes that share pathways with LRRC4C: view

Pathways by source for LRRC4C Gene

2 KEGG pathways for LRRC4C Gene

SIGNOR curated interactions for LRRC4C Gene

Other effect:

Gene Ontology (GO) - Biological Process for LRRC4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050770 regulation of axonogenesis IDA 14595443
GO:0050804 modulation of chemical synaptic transmission IEA --
GO:0099560 synaptic membrane adhesion IGI 23986473
genes like me logo Genes that share ontologies with LRRC4C: view

Drugs & Compounds for LRRC4C Gene

No Compound Related Data Available

Transcripts for LRRC4C Gene

mRNA/cDNA for LRRC4C Gene

Unigene Clusters for LRRC4C Gene

Leucine rich repeat containing 4C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC4C

Clone Products

  • Applied Biological Materials (abm): Clones for LRRC4C - Now 50% OFF >
  • * LRRC4C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * LRRC4C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC4C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP4: - - -

Relevant External Links for LRRC4C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC4C Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for LRRC4C Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC4C Gene

Protein tissue co-expression partners for LRRC4C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC4C Gene:


SOURCE GeneReport for Unigene cluster for LRRC4C Gene:


mRNA Expression by UniProt/SwissProt for LRRC4C Gene:

Tissue specificity: Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression.

Evidence on tissue expression from TISSUES for LRRC4C Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with LRRC4C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC4C Gene

Orthologs for LRRC4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC4C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC4C 35 34
  • 99.69 (n)
(Monodelphis domestica)
Mammalia LRRC4C 35
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC4C 35
  • 97 (a)
(Canis familiaris)
Mammalia LRRC4C 35 34
  • 95.1 (n)
(Bos Taurus)
Mammalia LRRC4C 35 34
  • 94.9 (n)
(Mus musculus)
Mammalia Lrrc4c 17 35 34
  • 93.23 (n)
(Rattus norvegicus)
Mammalia Lrrc4c 34
  • 93.12 (n)
(Gallus gallus)
Aves LRRC4C 35 34
  • 85.79 (n)
(Anolis carolinensis)
Reptilia LRRC4C 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc4c 34
  • 79.6 (n)
(Danio rerio)
Actinopterygii LRRC4C 35
  • 73 (a)
sc:d0316 34
  • 68.53 (n)
wufd12d10 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
Species where no ortholog for LRRC4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC4C Gene

Gene Tree for LRRC4C (if available)
Gene Tree for LRRC4C (if available)
Evolutionary constrained regions (ECRs) for LRRC4C: view image

Paralogs for LRRC4C Gene

(4) SIMAP similar genes for LRRC4C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC4C: view

Variants for LRRC4C Gene

Sequence variations from dbSNP and Humsavar for LRRC4C Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000000042 -- 40,527,643(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000003613 -- 41,182,926(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000004912 -- 40,508,162(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000007690 -- 41,389,294(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000010453 -- 40,591,202(-) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC4C Gene

Variant ID Type Subtype PubMed ID
esv2759823 CNV loss 17122850
esv2760566 CNV loss 21179565
esv2762907 CNV gain 21179565
esv27841 CNV loss 19812545
esv3149503 CNV deletion 24192839
nsv527603 CNV loss 19592680
nsv554085 CNV loss 21841781
nsv554086 CNV loss 21841781
nsv554087 CNV loss 21841781
nsv554088 CNV loss 21841781
nsv554089 CNV loss 21841781
nsv526365 CNV loss 19592680
nsv523225 CNV gain 19592680
nsv523070 CNV loss 19592680
nsv520942 CNV loss 19592680
nsv520201 CNV loss 19592680
nsv514614 CNV gain 21397061
nsv510250 OTHER sequence alteration 20534489
nsv508625 CNV deletion 20534489
nsv507590 OTHER sequence alteration 20534489
nsv467866 CNV loss 19166990
nsv467865 CNV loss 19166990
nsv442227 CNV gain 18776908
nsv39488 CNV deletion 16902084
nsv39060 CNV deletion 16902084
nsv38933 CNV deletion 16902084
nsv1148093 CNV deletion 26484159
nsv1144554 CNV deletion 24896259
nsv1142108 CNV tandem duplication 24896259
nsv1138013 CNV deletion 24896259
nsv1138012 CNV deletion 24896259
nsv1134109 CNV deletion 24896259
nsv1110890 OTHER inversion 24896259
nsv1078065 CNV deletion 25765185
nsv1069577 CNV deletion 25765185
nsv1069576 CNV deletion 25765185
nsv1049298 CNV gain 25217958
nsv1040072 CNV loss 25217958
nsv1039904 CNV loss 25217958
nsv1039332 CNV loss 25217958
nsv1037066 CNV loss 25217958
nsv1036216 CNV loss 25217958
esv997366 CNV deletion 20482838
esv988637 CNV deletion 20482838
esv8984 CNV loss 19470904
esv5191 CNV loss 18987735
esv4634 CNV loss 18987735
esv3891968 CNV gain 25118596
esv3626085 CNV gain 21293372
esv3626084 CNV loss 21293372
esv3626083 CNV loss 21293372
esv3626080 CNV loss 21293372
esv3626078 CNV loss 21293372
esv3626077 CNV loss 21293372
esv3626074 CNV loss 21293372
esv3626073 CNV loss 21293372
esv3626072 CNV loss 21293372
esv3626071 CNV loss 21293372
esv3626069 CNV loss 21293372
esv3626068 CNV loss 21293372
esv3626067 CNV loss 21293372
esv3626066 CNV loss 21293372
esv3626064 CNV loss 21293372
esv3626063 CNV loss 21293372
esv3626062 CNV loss 21293372
esv3626061 CNV loss 21293372
esv3626060 CNV loss 21293372
esv3626059 CNV loss 21293372
esv3626058 CNV loss 21293372
esv3626057 CNV loss 21293372
esv3579486 CNV loss 25503493
esv3579485 CNV loss 25503493
esv3579484 CNV loss 25503493
esv3579482 CNV loss 25503493
esv3547639 CNV deletion 23714750
esv3547637 CNV deletion 23714750
esv3547635 CNV deletion 23714750
esv3547634 CNV deletion 23714750
esv3547631 CNV deletion 23714750
esv3439455 CNV insertion 20981092
esv3435360 CNV insertion 20981092
esv3431482 CNV insertion 20981092
esv3429881 CNV insertion 20981092
esv3421064 CNV insertion 20981092
esv3362865 CNV insertion 20981092
esv3336174 CNV insertion 20981092
esv3308596 CNV mobile element insertion 20981092
esv3308528 CNV mobile element insertion 20981092
esv3308216 CNV mobile element insertion 20981092
esv3305759 CNV mobile element insertion 20981092
esv2759822 CNV loss 17122850
esv2751023 CNV loss 17911159
esv2744398 CNV deletion 23290073
esv2744396 CNV deletion 23290073
esv2744395 CNV deletion 23290073
esv2744394 CNV deletion 23290073
esv2744393 CNV deletion 23290073
esv2744392 CNV deletion 23290073
esv2744391 CNV deletion 23290073
esv2744390 CNV deletion 23290073
esv2744389 CNV deletion 23290073
esv2677712 CNV deletion 23128226
esv2677602 CNV deletion 23128226
esv2665329 CNV deletion 23128226
esv2664526 CNV deletion 23128226
esv2662552 CNV deletion 23128226
esv2661480 CNV deletion 23128226
esv2621057 CNV insertion 19546169
esv2533975 CNV deletion 19546169
esv2527036 CNV deletion 19546169
esv2488139 CNV loss 19546169
esv2420435 CNV deletion 18987734
esv2315564 CNV deletion 18987734
esv22215 CNV gain 19812545
esv21594 CNV gain 19812545
esv2119738 CNV deletion 18987734
esv2087348 CNV deletion 18987734
esv1949037 CNV deletion 18987734
esv1589619 CNV deletion 17803354
esv1344994 CNV deletion 17803354
esv1216399 CNV insertion 17803354
esv1051262 CNV deletion 17803354
esv1007997 CNV deletion 20482838
esv1000710 CNV deletion 20482838
dgv65n21 CNV gain 19592680
dgv625n106 CNV deletion 24896259
dgv624n106 CNV deletion 24896259
dgv193e214 CNV loss 21293372
dgv1106n100 CNV loss 25217958
dgv1105n100 CNV loss 25217958
nsv958624 CNV deletion 24416366
nsv8811 CNV loss 18304495
nsv8810 CNV gain 18304495
nsv832130 CNV gain 17160897
nsv832129 CNV gain 17160897
nsv832128 CNV gain+loss 17160897
nsv818814 CNV loss 17921354
nsv7747 CNV insertion 18451855
nsv7746 CNV insertion 18451855
nsv7744 CNV deletion 18451855
nsv554093 CNV loss 21841781
nsv554092 CNV loss 21841781
nsv554091 CNV loss 21841781
nsv554090 CNV loss 21841781

Variation tolerance for LRRC4C Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC4C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC4C Gene

Disorders for LRRC4C Gene

MalaCards: The human disease database

(3) MalaCards diseases for LRRC4C Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
extragonadal seminoma
  • primary extragonadal seminoma
chief cell adenoma
  • chief cell adenoma of parathyroid gland
propionic acidemia
  • propionyl-coa carboxylase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC4C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LRRC4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC4C Gene

Publications for LRRC4C Gene

  1. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. (PMID: 14595443) Lin JC … Rosenthal A (Nature neuroscience 2003) 2 3 4 58
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 45 58
  3. Structural basis for cell surface patterning through NetrinG-NGL interactions. (PMID: 21946559) Seiradake E … Jones EY (The EMBO journal 2011) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LRRC4C Gene

Sources for LRRC4C Gene

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