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Aliases for LRRC41 Gene

Aliases for LRRC41 Gene

  • Leucine Rich Repeat Containing 41 2 3 5
  • Protein Muf1 3 4
  • MUF1 3 4
  • Elongin BC-Interacting Leucine-Rich Repeat Protein 3
  • Leucine-Rich Repeat-Containing Protein 41 3
  • MUF1 Protein (MUF1) 3
  • PP7759 3

External Ids for LRRC41 Gene

Previous GeneCards Identifiers for LRRC41 Gene

  • GC01M046457
  • GC01M046726
  • GC01M044859

Summaries for LRRC41 Gene

GeneCards Summary for LRRC41 Gene

LRRC41 (Leucine Rich Repeat Containing 41) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for LRRC41 Gene

  • Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for LRRC41 Gene

Additional gene information for LRRC41 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC41 Gene

Genomics for LRRC41 Gene

GeneHancer (GH) Regulatory Elements for LRRC41 Gene

Promoters and enhancers for LRRC41 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046299 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 695.6 +0.8 830 5.6 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 LRRC41 UQCRH GC01P046305 GC01P046304 GPBP1L1 LURAP1 TOE1 RPL7AP16 EFCAB14-AS1 NASP
GH01J046330 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 661.8 -28.9 -28869 3 HDGF ELF3 PKNOX1 FOXA2 SMAD1 RB1 ARID4B BMI1 RAD21 RARA LRRC41 LURAP1 UQCRH GC01M046335 GC01P046304 GC01P046305
GH01J046129 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 103 +170.7 170655 6.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PIK3R3 LOC101929626 TOE1 GPBP1L1 LRRC41 RPL7AP16 EFCAB14-AS1 RPS15AP10 TMEM69 MOB3C
GH01J046717 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 91.4 -415.2 -415177 3.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 EFCAB14 PIR52630 LRRC41 EFCAB14-AS1 NSUN4 LINC01389 TEX38 CYP4B1 MOB3C ATPAF1
GH01J045684 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 84.4 +616.6 616638 5.1 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GPBP1L1 TMEM69 TOE1 LRRC41 RPS8 RPL7AP16 EFCAB14-AS1 HECTD3 MUTYH MAST2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC41 gene promoter:
  • AREB6
  • YY1
  • RREB-1
  • ER-alpha
  • IRF-1
  • ZID
  • Pax-5
  • deltaCREB
  • CREB
  • GATA-1

Genomic Locations for LRRC41 Gene

Genomic Locations for LRRC41 Gene
chr1:46,261,196-46,303,608
(GRCh38/hg38)
Size:
42,413 bases
Orientation:
Minus strand
chr1:46,726,868-46,769,280
(GRCh37/hg19)
Size:
42,413 bases
Orientation:
Minus strand

Genomic View for LRRC41 Gene

Genes around LRRC41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC41 Gene

Proteins for LRRC41 Gene

  • Protein details for LRRC41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15345-LRC41_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 41
    Protein Accession:
    Q15345
    Secondary Accessions:
    • A8K5G8
    • Q3MJ96
    • Q5TDF5
    • Q71RA8
    • Q9BSM0

    Protein attributes for LRRC41 Gene

    Size:
    812 amino acids
    Molecular mass:
    88650 Da
    Quaternary structure:
    • Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, ELOB and ELOC.
    SequenceCaution:
    • Sequence=AAQ15266.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15266.1; Type=Frameshift; Positions=56, 132; Evidence={ECO:0000305}; Sequence=CAA60013.1; Type=Frameshift; Positions=799; Evidence={ECO:0000305}; Sequence=CAD97609.1; Type=Frameshift; Positions=132, 186; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC41 Gene

Post-translational modifications for LRRC41 Gene

  • Ubiquitination at isoforms=3375 and posLast=199199
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC41 Gene

No data available for DME Specific Peptides for LRRC41 Gene

Domains & Families for LRRC41 Gene

Gene Families for LRRC41 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15345

UniProtKB/Swiss-Prot:

LRC41_HUMAN :
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with LRRC41: view

Function for LRRC41 Gene

Molecular function for LRRC41 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for LRRC41 Gene

Gene Ontology (GO) - Molecular Function for LRRC41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with LRRC41: view
genes like me logo Genes that share phenotypes with LRRC41: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC41

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC41 Gene

Localization for LRRC41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC41 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with LRRC41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC41 Gene

Pathways & Interactions for LRRC41 Gene

genes like me logo Genes that share pathways with LRRC41: view

UniProtKB/Swiss-Prot Q15345-LRC41_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for LRRC41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with LRRC41: view

No data available for SIGNOR curated interactions for LRRC41 Gene

Drugs & Compounds for LRRC41 Gene

No Compound Related Data Available

Transcripts for LRRC41 Gene

mRNA/cDNA for LRRC41 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(404) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC41 Gene

Leucine rich repeat containing 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC41

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC41 Gene

No ASD Table

Relevant External Links for LRRC41 Gene

GeneLoc Exon Structure for
LRRC41
ECgene alternative splicing isoforms for
LRRC41

Expression for LRRC41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC41 Gene

Protein differential expression in normal tissues from HIPED for LRRC41 Gene

This gene is overexpressed in Breast (27.0), Bone (13.7), and Monocytes (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC41 Gene



Protein tissue co-expression partners for LRRC41 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC41 Gene:

LRRC41

SOURCE GeneReport for Unigene cluster for LRRC41 Gene:

Hs.144941

Evidence on tissue expression from TISSUES for LRRC41 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Pancreas(4.2)
  • Kidney(2.7)
  • Lung(2.6)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with LRRC41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC41 Gene

Orthologs for LRRC41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC41 34 33
  • 99.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
OneToMany
LRRC41 33
  • 94.82 (n)
-- 34
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LRRC41 34 33
  • 94.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc41 33
  • 90.26 (n)
mouse
(Mus musculus)
Mammalia Lrrc41 16 34 33
  • 90.23 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC41 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC41 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC41 34 33
  • 59.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC41 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc41 33
  • 52.81 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-342h5.2 33
  • 42.8 (n)
LRRC41 34
  • 28 (a)
OneToOne
Species where no ortholog for LRRC41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC41 Gene

ENSEMBL:
Gene Tree for LRRC41 (if available)
TreeFam:
Gene Tree for LRRC41 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC41: view image

Paralogs for LRRC41 Gene

No data available for Paralogs for LRRC41 Gene

Variants for LRRC41 Gene

Sequence variations from dbSNP and Humsavar for LRRC41 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000106401 -- 46,302,431(-) C/G/T intron_variant
rs1000153699 -- 46,287,147(-) C/A/T intron_variant
rs1000281674 -- 46,283,748(-) C/T intron_variant
rs1000434365 -- 46,290,700(-) G/A intron_variant
rs1000468251 -- 46,289,595(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC41 Gene

Variant ID Type Subtype PubMed ID
esv2761743 CNV gain 21179565
esv3585930 CNV gain 21293372
esv3585931 CNV gain 21293372
nsv470711 CNV gain 18288195
nsv829748 CNV loss 17160897

Variation tolerance for LRRC41 Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC41 Gene

Human Gene Mutation Database (HGMD)
LRRC41
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC41 Gene

Disorders for LRRC41 Gene

Additional Disease Information for LRRC41

No disorders were found for LRRC41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC41 Gene

Publications for LRRC41 Gene

  1. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. (PMID: 11384984) Kamura T … Conaway JW (The Journal of biological chemistry 2001) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for LRRC41 Gene

Sources for LRRC41 Gene

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