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Aliases for LRRC37B Gene
Aliases for LRRC37B Gene
External Ids for LRRC37B Gene
- HGNC: 29070
- Entrez Gene: 114659
- Ensembl: ENSG00000185158
- OMIM: 616558
- UniProtKB: Q96QE4
Previous GeneCards Identifiers for LRRC37B Gene
- GC17P027373
- GC17P030348
- GC17P026558
- GC17P030334
Summaries for LRRC37B Gene
GeneCards Summary for LRRC37B Gene
LRRC37B (Leucine Rich Repeat Containing 37B) is a Protein Coding gene. Diseases associated with LRRC37B include Chromosome 17Q11.2 Deletion Syndrome and Chromosome 15Q26-Qter Deletion Syndrome. An important paralog of this gene is LRRC37A3.
Additional gene information for LRRC37B Gene
- HGNC(29070)
- Entrez Gene(114659)
- Ensembl(ENSG00000185158)
- OMIM(616558)
- UniProtKB(Q96QE4)
- Open Targets Platform(ENSG00000185158)
- Search for LRRC37B at DataMed
- Search for LRRC37B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC37B Gene
Genomics for LRRC37B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LRRC37B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LRRC37B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC37B
- Top Transcription factor binding sites by QIAGEN in the LRRC37B gene promoter:
-
- ATF6
- FAC1
- FOXO1
- FOXO1a
- Lmo2
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- STAT3
- STAT5A
Genomic Locations for LRRC37B Gene
Genomic Locations for LRRC37B Gene
- chr17:32,007,383-32,053,504
- (GRCh38/hg38)
- Size:
- 46,122 bases
- Orientation:
- Plus strand
- chr17:30,334,891-30,380,523
- (GRCh37/hg19)
- Size:
- 45,633 bases
- Orientation:
- Plus strand
Genomic View for LRRC37B Gene
Genes around LRRC37B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by HGNC
- 17q11.2 by Entrez Gene
- 17q11.2 by Ensembl
LRRC37B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LRRC37B Gene
Proteins for LRRC37B Gene
-
Protein details for LRRC37B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QE4-LR37B_HUMAN
- Recommended name:
- Leucine-rich repeat-containing protein 37B
- Protein Accession:
- Q96QE4
- Q17RC9
- Q5YKG6
Protein attributes for LRRC37B Gene
- Size:
- 947 amino acids
- Molecular mass:
- 105567 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAR28082.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for LRRC37B Gene
Post-translational modifications for LRRC37B Gene
Other Protein References for LRRC37B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LRRC37B
- Novus Biologicals Antibodies for LRRC37B
- Invitrogen Antibodies for LRRC37B (AFLGC-LRRC37B)
- antibodies-online: Show 10 available LRRC37B Antibodies ranked by validation data
-
Biorbyt antibodies for LRRC37B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LRRC37B
- Origene Custom Protein Services for LRRC37B
- Novus Biologicals proteins for LRRC37B
No data available for DME Specific Peptides for LRRC37B Gene
Domains & Families for LRRC37B Gene
Gene Families for LRRC37B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for LRRC37B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LRRC37B Gene
- GenScript: Design optimal peptide antigens:
-
- C66 SLIT-like testicular protein (LR37B_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC37B Gene
Function for LRRC37B Gene
Phenotypes From GWAS Catalog for LRRC37B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for LRRC37B Gene
- GenomeRNAi human phenotypes for LRRC37B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LRRC37B - Select products 50% OFF >
- * LRRC37B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LRRC37B
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-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRC37B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRRC37B
- Browse OriGene Inhibitory RNA Products For LRRC37B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC37B
Clone Products
- Applied Biological Materials (abm): Clones for LRRC37B - Select products 50% OFF >
- * LRRC37B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LRRC37B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRRC37B
Cell Line Products
-
Horizon Cell Lines for LRRC37B
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37B Gene
Localization for LRRC37B Gene
Subcellular locations from UniProtKB/Swiss-Prot for LRRC37B Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| extracellular | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for LRRC37B Gene
Interacting Proteins for LRRC37B Gene
GPS-Prot Interaction Network for LRRC37B
No data available for Pathways by source and SIGNOR curated interactions for LRRC37B Gene
Transcripts for LRRC37B Gene
mRNA/cDNA for LRRC37B Gene
- 2 REFSEQ mRNAs :
- 43 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000327564 3162 nts (view in UCSC)
- ENST00000341671 3025 nts (view in UCSC)
- ENST00000394713 3025 nts (view in UCSC)
- ENST00000543378 3091 nts (view in UCSC)
- ENST00000578118 579 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LRRC37B - Select products 50% OFF >
- * LRRC37B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LRRC37B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRRC37B
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRC37B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRRC37B
- Browse OriGene Inhibitory RNA Products For LRRC37B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC37B
Clone Products
- Applied Biological Materials (abm): Clones for LRRC37B - Select products 50% OFF >
- * LRRC37B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LRRC37B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRRC37B
Relevant External Links for LRRC37B Gene
- GeneLoc Exon Structure for
- LRRC37B
Expression for LRRC37B Gene
This gene is overexpressed in Testis (54.1) and Ovary (14.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC37B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC37B
SOURCE GeneReport for Unigene cluster for LRRC37B Gene:
Hs.514071Evidence on tissue expression from TISSUES for LRRC37B Gene
- Stomach(4.5)
- Liver(4.1)
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for LRRC37B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37B Gene
Orthologs for LRRC37B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LRRC37B 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Gm884 31 |
|
ManyToMany | |
| Lrrc37a 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for LRRC37B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for LRRC37B Gene
- ENSEMBL:
- Gene Tree for LRRC37B (if available)
- TreeFam:
- Gene Tree for LRRC37B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LRRC37B: view image
Paralogs for LRRC37B Gene
(4) SIMAP similar genes for LRRC37B Gene using alignment to 9 proteins:
- LR37B_HUMAN
- F5H5K1_HUMAN
- J3KTP0_HUMAN
- J3QKM3_HUMAN
- J3QL10_HUMAN
- J3QLE7_HUMAN
- J3QLI7_HUMAN
- J3QSU1_HUMAN
- Q17RC9_HUMAN
Pseudogenes.org Pseudogenes for LRRC37B Gene
Variants for LRRC37B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758684 | CNV | gain | 17122850 |
| esv3640375 | CNV | gain | 21293372 |
| nsv1062194 | CNV | gain | 25217958 |
| nsv9536 | CNV | gain | 18304495 |
| nsv962309 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.57;
44.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LRRC37B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LRRC37B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC37B Gene
Disorders for LRRC37B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 17q11.2 deletion syndrome |
|
|
| chromosome 15q26-qter deletion syndrome |
|
|
| plexiform neurofibroma |
|
|
Search LRRC37B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LRRC37B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC37B Gene
Publications for LRRC37B Gene
- A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PMID: 10843809) Jenne DE … Thiel G (Genomics 2000) 2 3 4
- RNF135 mutations are not present in patients with Sotos syndrome-like features. (PMID: 19291764) Visser R … Losekoot M (American journal of medical genetics. Part A 2009) 3 41
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
- Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PMID: 11468690) Jenne DE … Kehrer-Sawatzki H (American journal of human genetics 2001) 2 3
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
ExternalLinks
Products for LRRC37B Gene
- Custom Antibody ServicesOriGene Antibodies for LRRC37B
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for LRRC37B
- Origene Custom Protein Services for LRRC37B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRRC37B
- Browse OriGene Inhibitory RNA Products For LRRC37B
- OriGene qPCR primer pairs for LRRC37B
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for LRRC37B
- Novus Biologicals proteins for LRRC37B
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for LRRC37B (AFLGC-LRRC37B)
- VectorBuilder Custom and pre-made DNA vectors for LRRC37B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for LRRC37B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for LRRC37B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for LRRC37B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for LRRC37B
- antibodies-online: Show 10 available LRRC37B Antibodies ranked by validation data
- antibodies-online: Search results for available LRRC37B related products ranked by validation data
- antibodies-online: Search results for available LRRC37B related products ranked by validation data
- Horizon Cell Lines for LRRC37B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRRC37B
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for LRRC37B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC37B
- Biorbyt antibodies for LRRC37B
Sources for LRRC37B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB