Aliases for LRRC37B Gene

Aliases for LRRC37B Gene

  • Leucine Rich Repeat Containing 37B 2 3 5
  • Leucine-Rich Repeat-Containing Protein 37B 3 4
  • C66 SLIT-Like Testicular Protein 3 4
  • KIAA0563-Related 2
  • LRRC37 3

External Ids for LRRC37B Gene

Previous GeneCards Identifiers for LRRC37B Gene

  • GC17P027373
  • GC17P030348
  • GC17P026558
  • GC17P030334

Summaries for LRRC37B Gene

GeneCards Summary for LRRC37B Gene

LRRC37B (Leucine Rich Repeat Containing 37B) is a Protein Coding gene. An important paralog of this gene is LRRC37A2.

Additional gene information for LRRC37B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC37B Gene

Genomics for LRRC37B Gene

GeneHancer (GH) Regulatory Elements for LRRC37B Gene

Promoters and enhancers for LRRC37B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC37B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC37B gene promoter:
  • ATF6
  • FAC1
  • FOXO1
  • FOXO1a
  • Lmo2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT3
  • STAT5A

Genomic Locations for LRRC37B Gene

Genomic Locations for LRRC37B Gene
chr17:32,007,372-32,053,504
(GRCh38/hg38)
Size:
46,133 bases
Orientation:
Plus strand
chr17:30,334,891-30,380,523
(GRCh37/hg19)
Size:
45,633 bases
Orientation:
Plus strand

Genomic View for LRRC37B Gene

Genes around LRRC37B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37B Gene

Proteins for LRRC37B Gene

  • Protein details for LRRC37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QE4-LR37B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 37B
    Protein Accession:
    Q96QE4
    Secondary Accessions:
    • Q17RC9
    • Q5YKG6

    Protein attributes for LRRC37B Gene

    Size:
    947 amino acids
    Molecular mass:
    105567 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAR28082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC37B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC37B Gene

Post-translational modifications for LRRC37B Gene

  • Glycosylation at Asn358 and Asn789
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC37B Gene

Domains & Families for LRRC37B Gene

Gene Families for LRRC37B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRRC37B Gene

Suggested Antigen Peptide Sequences for LRRC37B Gene

GenScript: Design optimal peptide antigens:
  • C66 SLIT-like testicular protein (LR37B_HUMAN)
genes like me logo Genes that share domains with LRRC37B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC37B Gene

Function for LRRC37B Gene

Phenotypes From GWAS Catalog for LRRC37B Gene

Phenotypes for LRRC37B Gene

genes like me logo Genes that share phenotypes with LRRC37B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37B Gene

Localization for LRRC37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC37B gene
Compartment Confidence
plasma membrane 2
peroxisome 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37B: view

Pathways & Interactions for LRRC37B Gene

PathCards logo

SuperPathways for LRRC37B Gene

No Data Available

Interacting Proteins for LRRC37B Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000340519 Q96QE4-LR37B_HUMAN for LRRC37B Gene via STRING IID

Gene Ontology (GO) - Biological Process for LRRC37B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC37B Gene

Drugs & Compounds for LRRC37B Gene

No Compound Related Data Available

Transcripts for LRRC37B Gene

mRNA/cDNA for LRRC37B Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37B Gene

No ASD Table

Relevant External Links for LRRC37B Gene

GeneLoc Exon Structure for
LRRC37B
ECgene alternative splicing isoforms for
LRRC37B

Expression for LRRC37B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC37B Gene

Protein differential expression in normal tissues from HIPED for LRRC37B Gene

This gene is overexpressed in Testis (54.1) and Ovary (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC37B Gene



Protein tissue co-expression partners for LRRC37B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC37B Gene:

LRRC37B

SOURCE GeneReport for Unigene cluster for LRRC37B Gene:

Hs.514071

Evidence on tissue expression from TISSUES for LRRC37B Gene

  • Stomach(4.5)
  • Liver(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with LRRC37B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37B Gene

Orthologs for LRRC37B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC37B 32
  • 98.58 (n)
-- 33
  • 97 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 33
  • 27 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm884 33
  • 23 (a)
ManyToMany
Lrrc37a 33
  • 10 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 19 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 17 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 15 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 20 (a)
OneToMany
Species where no ortholog for LRRC37B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37B Gene

ENSEMBL:
Gene Tree for LRRC37B (if available)
TreeFam:
Gene Tree for LRRC37B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC37B: view image

Paralogs for LRRC37B Gene

Paralogs for LRRC37B Gene

(4) SIMAP similar genes for LRRC37B Gene using alignment to 9 proteins:

  • LR37B_HUMAN
  • F5H5K1_HUMAN
  • J3KTP0_HUMAN
  • J3QKM3_HUMAN
  • J3QL10_HUMAN
  • J3QLE7_HUMAN
  • J3QLI7_HUMAN
  • J3QSU1_HUMAN
  • Q17RC9_HUMAN
genes like me logo Genes that share paralogs with LRRC37B: view

Variants for LRRC37B Gene

Sequence variations from dbSNP and Humsavar for LRRC37B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000179219 -- 32,036,267(+) CTA/CTACTA intron_variant
rs1000240553 -- 32,029,013(+) T/A intron_variant
rs1000292902 -- 32,029,164(+) G/ intron_variant
rs1000621029 -- 32,042,299(+) C/T intron_variant
rs1000636006 -- 32,035,967(+) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC37B Gene

Variant ID Type Subtype PubMed ID
esv2758684 CNV gain 17122850
esv3640375 CNV gain 21293372
nsv1062194 CNV gain 25217958
nsv9536 CNV gain 18304495
nsv962309 CNV duplication 23825009

Variation tolerance for LRRC37B Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC37B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC37B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37B Gene

Disorders for LRRC37B Gene

Additional Disease Information for LRRC37B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRC37B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC37B Gene

Publications for LRRC37B Gene

  1. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PMID: 10843809) Jenne DE … Thiel G (Genomics 2000) 2 3 4 56
  2. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PMID: 19291764) Visser R … Losekoot M (American journal of medical genetics. Part A 2009) 3 43 56
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 56
  4. Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PMID: 11468690) Jenne DE … Kehrer-Sawatzki H (American journal of human genetics 2001) 2 3 56
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56

Products for LRRC37B Gene

Sources for LRRC37B Gene