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Aliases for LRRC37B Gene

Aliases for LRRC37B Gene

  • Leucine Rich Repeat Containing 37B 2 3 5
  • C66 SLIT-Like Testicular Protein 3 4
  • Leucine-Rich Repeat-Containing Protein 37B 3
  • KIAA0563-Related 2
  • LRRC37 3

External Ids for LRRC37B Gene

Previous GeneCards Identifiers for LRRC37B Gene

  • GC17P027373
  • GC17P030348
  • GC17P026558
  • GC17P030334

Summaries for LRRC37B Gene

GeneCards Summary for LRRC37B Gene

LRRC37B (Leucine Rich Repeat Containing 37B) is a Protein Coding gene. An important paralog of this gene is LRRC37A3.

Additional gene information for LRRC37B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC37B Gene

Genomics for LRRC37B Gene

GeneHancer (GH) Regulatory Elements for LRRC37B Gene

Promoters and enhancers for LRRC37B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I032006 Promoter/Enhancer 1.5 Ensembl ENCODE 550.8 +0.5 512 2.6 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF213 E2F8 ZNF143 KLF13 ENSG00000264300 LRRC37B PIR62613 UTP6 SUZ12 ZNF207 COPRS LOC105371730 RHOT1
GH17I032021 Promoter 0.5 EPDnew 550.4 +13.7 13717 0.1 GC17M032014 LRRC37B PIR55336
GH17I032348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.6 +343.3 343258 4.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF207 C17orf75 GC17M032350 GC17P032358 PIR54391 MIR632 SUZ12 UTP6 PSMD11 LRRC37B
GH17I031486 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -515.6 -515614 10.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 POLR2B ZNF207 RAB11FIP4 EVI2B ENSG00000266490 LOC105371722 LRRC37B EVI2A SUZ12 GC17P031509 RN7SL79P
GH17I031936 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 -69.8 -69793 2.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 ZNF143 SUZ12 ZNF207 UTP6 ENSG00000264456 NF1 ENSG00000263990 RNF135 COPRS DPRXP4 LOC105371722
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC37B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC37B gene promoter:

Genomic Locations for LRRC37B Gene

Genomic Locations for LRRC37B Gene
46,133 bases
Plus strand

Genomic View for LRRC37B Gene

Genes around LRRC37B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37B Gene

Proteins for LRRC37B Gene

  • Protein details for LRRC37B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 37B
    Protein Accession:
    Secondary Accessions:
    • Q17RC9
    • Q5YKG6

    Protein attributes for LRRC37B Gene

    947 amino acids
    Molecular mass:
    105567 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAR28082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC37B Gene


neXtProt entry for LRRC37B Gene

Post-translational modifications for LRRC37B Gene

  • Glycosylation at isoforms=2358 and isoforms=2789
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC37B Gene

Domains & Families for LRRC37B Gene

Gene Families for LRRC37B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LRRC37B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC37B: view

No data available for UniProtKB/Swiss-Prot for LRRC37B Gene

Function for LRRC37B Gene

Phenotypes From GWAS Catalog for LRRC37B Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37B Gene

Localization for LRRC37B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC37B gene
Compartment Confidence
plasma membrane 2
peroxisome 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC37B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37B: view

Pathways & Interactions for LRRC37B Gene

SuperPathways for LRRC37B Gene

No Data Available

Interacting Proteins for LRRC37B Gene

Gene Ontology (GO) - Biological Process for LRRC37B Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC37B Gene

Drugs & Compounds for LRRC37B Gene

No Compound Related Data Available

Transcripts for LRRC37B Gene

Unigene Clusters for LRRC37B Gene

Leucine rich repeat containing 37B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37B Gene

No ASD Table

Relevant External Links for LRRC37B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC37B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC37B Gene

Protein differential expression in normal tissues from HIPED for LRRC37B Gene

This gene is overexpressed in Testis (54.1) and Ovary (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC37B Gene

Protein tissue co-expression partners for LRRC37B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC37B Gene:


SOURCE GeneReport for Unigene cluster for LRRC37B Gene:


Evidence on tissue expression from TISSUES for LRRC37B Gene

  • Stomach(4.5)
  • Liver(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with LRRC37B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37B Gene

Orthologs for LRRC37B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC37B 33
  • 98.58 (n)
-- 34
  • 97 (a)
-- 34
  • 36 (a)
(Bos Taurus)
Mammalia -- 34
  • 27 (a)
(Mus musculus)
Mammalia Gm884 34
  • 23 (a)
Lrrc37a 34
  • 10 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 19 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 17 (a)
(Canis familiaris)
Mammalia -- 34
  • 15 (a)
(Gallus gallus)
Aves -- 34
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
Species where no ortholog for LRRC37B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37B Gene

Gene Tree for LRRC37B (if available)
Gene Tree for LRRC37B (if available)

Paralogs for LRRC37B Gene

Variants for LRRC37B Gene

Sequence variations from dbSNP and Humsavar for LRRC37B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000179219 -- 32,036,267(+) CTA/CTACTA intron_variant
rs1000240553 -- 32,029,013(+) T/A intron_variant
rs1000292902 -- 32,029,164(+) G/ intron_variant
rs1000621029 -- 32,042,299(+) C/T intron_variant
rs1000636006 -- 32,035,967(+) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC37B Gene

Variant ID Type Subtype PubMed ID
esv2758684 CNV gain 17122850
esv3640375 CNV gain 21293372
nsv1062194 CNV gain 25217958
nsv9536 CNV gain 18304495
nsv962309 CNV duplication 23825009

Variation tolerance for LRRC37B Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC37B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37B Gene

Disorders for LRRC37B Gene

Additional Disease Information for LRRC37B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRC37B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC37B Gene

Publications for LRRC37B Gene

  1. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PMID: 10843809) Jenne DE … Thiel G (Genomics 2000) 2 3 4 58
  2. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PMID: 19291764) Visser R … Losekoot M (American journal of medical genetics. Part A 2009) 3 44 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  4. Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PMID: 11468690) Jenne DE … Kehrer-Sawatzki H (American journal of human genetics 2001) 2 3 58
  5. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G … Eichler EE (Genome research 2013) 3 58

Products for LRRC37B Gene

Sources for LRRC37B Gene

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