Aliases for LRRC37A3 Gene

Aliases for LRRC37A3 Gene

  • Leucine Rich Repeat Containing 37 Member A3 2 3 5
  • Leucine-Rich Repeat-Containing Protein 37A3 3 4
  • KIAA0563 4
  • LRRC37A 3
  • LRRC37 3

External Ids for LRRC37A3 Gene

Previous GeneCards Identifiers for LRRC37A3 Gene

  • GC17M060281
  • GC17M062850
  • GC17M058309

Summaries for LRRC37A3 Gene

GeneCards Summary for LRRC37A3 Gene

LRRC37A3 (Leucine Rich Repeat Containing 37 Member A3) is a Protein Coding gene. Diseases associated with LRRC37A3 include Koolen-De Vries Syndrome and Supranuclear Palsy, Progressive, 1. An important paralog of this gene is LRRC37A2.

Additional gene information for LRRC37A3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC37A3 Gene

Genomics for LRRC37A3 Gene

GeneHancer (GH) Regulatory Elements for LRRC37A3 Gene

Promoters and enhancers for LRRC37A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC37A3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC37A3

Top Transcription factor binding sites by QIAGEN in the LRRC37A3 gene promoter:
  • ATF6
  • c-Myc
  • c-Rel
  • GR
  • GR-alpha
  • Lmo2
  • Max
  • MRF-2
  • N-Myc
  • Pax-5

Genomic Locations for LRRC37A3 Gene

Genomic Locations for LRRC37A3 Gene
65,334 bases
Minus strand
65,169 bases
Minus strand

Genomic View for LRRC37A3 Gene

Genes around LRRC37A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37A3 Gene

Proteins for LRRC37A3 Gene

  • Protein details for LRRC37A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 37A3
    Protein Accession:
    Secondary Accessions:
    • Q49A01
    • Q49A80
    • Q8NB33

    Protein attributes for LRRC37A3 Gene

    1634 amino acids
    Molecular mass:
    180621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25489.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC37A3 Gene

Post-translational modifications for LRRC37A3 Gene

  • Glycosylation at Asn296 and Asn1079
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC37A3 Gene

Domains & Families for LRRC37A3 Gene

Gene Families for LRRC37A3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRRC37A3 Gene

Suggested Antigen Peptide Sequences for LRRC37A3 Gene

GenScript: Design optimal peptide antigens:
  • LRRC37A3 protein (A0JLV1_HUMAN)
  • cDNA FLJ56239, highly similar to Leucine-rich repeat-containing protein 37A (B4DSF2_HUMAN)
  • Leucine-rich repeat-containing protein 37A3 (L37A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LRRC37A family.
  • Belongs to the LRRC37A family.
genes like me logo Genes that share domains with LRRC37A3: view

Function for LRRC37A3 Gene

Phenotypes From GWAS Catalog for LRRC37A3 Gene

genes like me logo Genes that share phenotypes with LRRC37A3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37A3 Gene

Localization for LRRC37A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC37A3 gene
Compartment Confidence
plasma membrane 2
extracellular 1
peroxisome 1
nucleus 1
mitochondrion 0
cytosol 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37A3: view

Pathways & Interactions for LRRC37A3 Gene

PathCards logo

SuperPathways for LRRC37A3 Gene

No Data Available

Interacting Proteins for LRRC37A3 Gene


Gene Ontology (GO) - Biological Process for LRRC37A3 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC37A3 Gene

Drugs & Compounds for LRRC37A3 Gene

No Compound Related Data Available

Transcripts for LRRC37A3 Gene

mRNA/cDNA for LRRC37A3 Gene

55 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37A3 Gene

No ASD Table

Relevant External Links for LRRC37A3 Gene

GeneLoc Exon Structure for

Expression for LRRC37A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC37A3 Gene

Protein differential expression in normal tissues from HIPED for LRRC37A3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC37A3 Gene

Protein tissue co-expression partners for LRRC37A3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC37A3

SOURCE GeneReport for Unigene cluster for LRRC37A3 Gene:


Evidence on tissue expression from TISSUES for LRRC37A3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with LRRC37A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37A3 Gene

Orthologs for LRRC37A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC37A3 30
  • 95.62 (n)
-- 31
  • 93 (a)
(Bos Taurus)
Mammalia -- 31
  • 46 (a)
(Canis familiaris)
Mammalia -- 31
  • 46 (a)
(Mus musculus)
Mammalia Gm884 31
  • 32 (a)
Lrrc37a 31
  • 16 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 19 (a)
(Gallus gallus)
Aves -- 31
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 25 (a)
Species where no ortholog for LRRC37A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37A3 Gene

Gene Tree for LRRC37A3 (if available)
Gene Tree for LRRC37A3 (if available)

Paralogs for LRRC37A3 Gene

Paralogs for LRRC37A3 Gene

(17) SIMAP similar genes for LRRC37A3 Gene using alignment to 9 proteins:

  • L37A3_HUMAN
  • F8W7X0_HUMAN
  • J3KT91_HUMAN
  • J3KT96_HUMAN
  • J3QL27_HUMAN
genes like me logo Genes that share paralogs with LRRC37A3: view

Variants for LRRC37A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC37A3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
730719 Benign: not provided 64,859,799(-) G/A SYNONYMOUS_VARIANT
768909 Benign: not provided 64,860,033(-) A/G SYNONYMOUS_VARIANT
768910 Benign: not provided 64,860,035(-) G/A MISSENSE_VARIANT
768911 Benign: not provided 64,860,939(-) C/T SYNONYMOUS_VARIANT
786657 Benign: not provided 64,860,222(-) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LRRC37A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC37A3 Gene

Variant ID Type Subtype PubMed ID
dgv1494n106 CNV deletion 24896259
dgv1793e59 CNV duplication 20981092
dgv1794e59 CNV duplication 20981092
dgv3274n100 CNV gain 25217958
dgv44n68 CNV loss 17160897
dgv45n68 CNV loss 17160897
dgv5743n54 CNV loss 21841781
esv24547 CNV gain 19812545
esv3344942 CNV duplication 20981092
esv3365612 CNV duplication 20981092
esv3382298 CNV duplication 20981092
esv3397467 CNV duplication 20981092
esv3413224 CNV duplication 20981092
esv3429501 CNV duplication 20981092
esv3436611 CNV duplication 20981092
nsv1066765 CNV gain 25217958
nsv1072747 CNV deletion 25765185
nsv1117181 CNV tandem duplication 24896259
nsv1120054 OTHER inversion 24896259
nsv469875 CNV loss 16826518
nsv471504 CNV gain 19718026
nsv575856 CNV gain 21841781
nsv575857 CNV gain 21841781
nsv575860 CNV gain 21841781
nsv575861 CNV gain+loss 21841781
nsv952360 CNV duplication 24416366
nsv9585 CNV gain+loss 18304495
nsv978455 CNV duplication 23825009

Variation tolerance for LRRC37A3 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC37A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Disorders for LRRC37A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC37A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
koolen-de vries syndrome
  • kdvs
supranuclear palsy, progressive, 1
  • psp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC37A3

genes like me logo Genes that share disorders with LRRC37A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC37A3 Gene

Publications for LRRC37A3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 54
  4. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G … Eichler EE (Genome research 2013) 3 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for LRRC37A3 Gene

Sources for LRRC37A3 Gene