Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LRRC37A Gene

Aliases for LRRC37A Gene

  • Leucine Rich Repeat Containing 37A 2 3 5
  • Leucine-Rich Repeat-Containing Protein 37A 3
  • LRRC37A1 4
  • LRRC37 3

External Ids for LRRC37A Gene

Previous GeneCards Identifiers for LRRC37A Gene

  • GC17P041733
  • GC17P044370

Summaries for LRRC37A Gene

GeneCards Summary for LRRC37A Gene

LRRC37A (Leucine Rich Repeat Containing 37A) is a Protein Coding gene. An important paralog of this gene is LRRC37A2.

Additional gene information for LRRC37A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC37A Gene

Genomics for LRRC37A Gene

GeneHancer (GH) Regulatory Elements for LRRC37A Gene

Promoters and enhancers for LRRC37A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J045893 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.9 -344.1 -344071 2.9 HDGF ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF143 MAPT-IT1 MAPT-AS1 MAPT GC17P045896 LINC02210 MAPK8IP1P1 ENSG00000262372 KANSL1 ARL17A ARL17B
GH17J045404 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.4 -828.5 -828516 13.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 ATF7 GC17M045407 LINC02210 LRRC37A4P ARHGAP27 ARL17B KANSL1 FMNL1 ENSG00000262372 SPATA32 LRRC37A
GH17J046024 Enhancer 0.9 Ensembl ENCODE dbSUPER 15.1 -213.0 -212981 3.6 PAF1 ZNF316 POLR2A MAFG EMSY MAFK LINC02210 LRRC37A4P LRRC37A2 NSFP1 LRRC37A STH KANSL1-AS1 ENSG00000262372 GC17P046011 GC17P046010
GH17J046162 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -75.7 -75680 2.2 ZSCAN5A ZNF777 ZSCAN4 MZF1 ZEB1 ZNF664 ZNF791 ZNF23 SCRT2 ZNF26 LINC02210 LRRC37A4P ARL17B ARL17A ENSG00000262372 KANSL1 RPS7P11 LRRC37A17P NSFP1 LRRC37A2
GH17J046741 Enhancer 1 Ensembl ENCODE 12.6 +503.4 503399 2.6 SMAD1 ZNF473 NFIB KLF17 ZNF195 NCOA2 GLIS2 EGR1 ZNF350 FOS KANSL1-AS1 ARL17B ENSG00000253347 ARL17A LRRC37A17P MRPL45P2 NSFP1 EFCAB13 RPS7P11 WNT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC37A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC37A gene promoter:
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • GCNF
  • GCNF-1
  • GCNF-2
  • Brachyury
  • Pax-2
  • Pax-2a

Genomic Locations for LRRC37A Gene

Genomic Locations for LRRC37A Gene
chr17:46,239,319-46,337,794
(GRCh38/hg38)
Size:
98,476 bases
Orientation:
Plus strand
chr17:44,370,099-44,415,160
(GRCh37/hg19)
Size:
45,062 bases
Orientation:
Plus strand

Genomic View for LRRC37A Gene

Genes around LRRC37A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37A Gene

Proteins for LRRC37A Gene

  • Protein details for LRRC37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMS7-L37A1_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 37A
    Protein Accession:
    A6NMS7
    Secondary Accessions:
    • Q68DY2
    • Q8IWC7

    Protein attributes for LRRC37A Gene

    Size:
    1700 amino acids
    Molecular mass:
    188258 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH18088.1; Type=Frameshift; Positions=8, 177; Evidence={ECO:0000305};

neXtProt entry for LRRC37A Gene

Post-translational modifications for LRRC37A Gene

  • Glycosylation at posLast=10791079 and isoforms=296
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC37A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC37A Gene

Domains & Families for LRRC37A Gene

Gene Families for LRRC37A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LRRC37A Gene

Suggested Antigen Peptide Sequences for LRRC37A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMS7

UniProtKB/Swiss-Prot:

L37A1_HUMAN :
  • Belongs to the LRRC37A family.
Family:
  • Belongs to the LRRC37A family.
genes like me logo Genes that share domains with LRRC37A: view

Function for LRRC37A Gene

Phenotypes From GWAS Catalog for LRRC37A Gene

genes like me logo Genes that share phenotypes with LRRC37A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37A Gene

Localization for LRRC37A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC37A gene
Compartment Confidence
plasma membrane 3
peroxisome 2
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37A: view

Pathways & Interactions for LRRC37A Gene

SuperPathways for LRRC37A Gene

No Data Available

Interacting Proteins for LRRC37A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326324%0d%0a9606.ENSP00000344352%0d%0a
Selected Interacting proteins: A6NMS7-L37A1_HUMAN ENSP00000326324 for LRRC37A Gene via IID STRING

Gene Ontology (GO) - Biological Process for LRRC37A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC37A Gene

Drugs & Compounds for LRRC37A Gene

No Compound Related Data Available

Transcripts for LRRC37A Gene

mRNA/cDNA for LRRC37A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC37A Gene

Leucine rich repeat containing 37A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37A Gene

No ASD Table

Relevant External Links for LRRC37A Gene

GeneLoc Exon Structure for
LRRC37A
ECgene alternative splicing isoforms for
LRRC37A

Expression for LRRC37A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC37A Gene

mRNA differential expression in normal tissues according to GTEx for LRRC37A Gene

This gene is overexpressed in Testis (x4.5).

Protein differential expression in normal tissues from HIPED for LRRC37A Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC37A Gene



Protein tissue co-expression partners for LRRC37A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC37A Gene:

LRRC37A

SOURCE GeneReport for Unigene cluster for LRRC37A Gene:

Hs.579108

Evidence on tissue expression from TISSUES for LRRC37A Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with LRRC37A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37A Gene

Orthologs for LRRC37A Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC37A3 33
  • 95.69 (n)
-- 34
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 48 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 48 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm884 34
  • 32 (a)
ManyToMany
Lrrc37a 34
  • 16 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 22 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
OneToMany
Species where no ortholog for LRRC37A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37A Gene

ENSEMBL:
Gene Tree for LRRC37A (if available)
TreeFam:
Gene Tree for LRRC37A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC37A: view image

Paralogs for LRRC37A Gene

Paralogs for LRRC37A Gene

(5) SIMAP similar genes for LRRC37A Gene using alignment to 3 proteins:

  • L37A1_HUMAN
  • A8MUI5_HUMAN
  • E9PP10_HUMAN

Pseudogenes.org Pseudogenes for LRRC37A Gene

genes like me logo Genes that share paralogs with LRRC37A: view

Variants for LRRC37A Gene

Sequence variations from dbSNP and Humsavar for LRRC37A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs62073222 benign, not specified 46,297,344(+) A/C/G/T coding_sequence_variant, intron_variant, synonymous_variant
rs1000121054 -- 46,262,831(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000194431 -- 46,279,679(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000288114 -- 46,260,939(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000424148 -- 46,286,396(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC37A Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv13n31 CNV gain 19718026
dgv29e213 CNV loss 24956385
dgv30e213 CNV gain 24956385
dgv3184n100 CNV gain 25217958
dgv3185n100 CNV gain 25217958
dgv3188n100 CNV gain 25217958
dgv3189n100 CNV gain 25217958
dgv3190n100 CNV gain 25217958
dgv3196n100 CNV gain+loss 25217958
dgv3198n100 CNV loss 25217958
dgv3206n100 CNV loss 25217958
dgv3209n100 CNV gain 25217958
dgv3214n100 CNV gain+loss 25217958
dgv3232n100 CNV loss 25217958
dgv3233n100 CNV gain 25217958
dgv3238n100 CNV gain 25217958
dgv3239n100 CNV gain 25217958
dgv3240n100 CNV gain 25217958
dgv3241n100 CNV loss 25217958
dgv3242n100 CNV gain+loss 25217958
dgv3244n100 CNV loss 25217958
dgv3245n100 CNV gain+loss 25217958
dgv3246n100 CNV gain+loss 25217958
dgv3247n100 CNV gain 25217958
dgv3248n100 CNV loss 25217958
dgv3249n100 CNV gain 25217958
dgv3250n100 CNV gain+loss 25217958
dgv3251n100 CNV loss 25217958
dgv3252n100 CNV loss 25217958
dgv3253n100 CNV loss 25217958
dgv3254n100 CNV gain+loss 25217958
dgv3255n100 CNV gain 25217958
dgv5618n54 CNV gain 21841781
dgv5623n54 CNV loss 21841781
dgv5628n54 CNV loss 21841781
dgv5638n54 CNV gain 21841781
dgv5641n54 CNV loss 21841781
dgv5642n54 CNV loss 21841781
dgv5643n54 CNV gain 21841781
dgv5644n54 CNV gain 21841781
dgv5645n54 CNV loss 21841781
dgv5646n54 CNV gain+loss 21841781
dgv5647n54 CNV loss 21841781
dgv939e212 CNV gain 25503493
dgv940e212 CNV loss 25503493
esv1003686 CNV gain 20482838
esv21783 CNV gain+loss 19812545
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv2760451 CNV gain+loss 21179565
esv2762433 CNV gain+loss 21179565
esv33048 CNV gain+loss 17666407
esv3395024 CNV duplication 20981092
esv3444693 CNV duplication 20981092
esv3450287 CNV duplication 20981092
esv3584722 CNV loss 24956385
esv3893017 CNV gain+loss 25118596
esv3893020 CNV gain 25118596
esv3893022 CNV gain 25118596
esv3893023 CNV gain+loss 25118596
nsv1061687 CNV loss 25217958
nsv1063349 CNV gain 25217958
nsv1072741 CNV deletion 25765185
nsv1118761 CNV deletion 24896259
nsv1126463 CNV deletion 24896259
nsv1136238 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1160492 CNV duplication 26073780
nsv1160494 CNV deletion 26073780
nsv163 CNV deletion 15895083
nsv2070 CNV deletion 18451855
nsv428343 CNV gain+loss 18775914
nsv442749 CNV gain+loss 18776908
nsv469697 CNV gain+loss 16826518
nsv471698 CNV gain+loss 15918152
nsv511057 OTHER complex 20534489
nsv516807 CNV gain+loss 19592680
nsv575266 CNV gain 21841781
nsv575272 CNV loss 21841781
nsv821581 CNV deletion 20802225
nsv821687 CNV gain 15273396
nsv953912 CNV deletion 24416366
nsv9564 CNV gain+loss 18304495
nsv960494 CNV duplication 23825009

Variation tolerance for LRRC37A Gene

Gene Damage Index Score: 3.76; 57.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC37A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC37A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37A Gene

Disorders for LRRC37A Gene

Additional Disease Information for LRRC37A

No disorders were found for LRRC37A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC37A Gene

Publications for LRRC37A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Structural evolution of the BRCA1 genomic region in primates. (PMID: 15533724) Jin H … Roberts RG (Genomics 2004) 2 3 58
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 58
  4. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G … Eichler EE (Genome research 2013) 3 58
  5. Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region. (PMID: 22419166) Bekpen C … Eichler EE (Genome research 2012) 3 58

Products for LRRC37A Gene

Sources for LRRC37A Gene

Content
Loading form....