Aliases for LRRC37A Gene

Aliases for LRRC37A Gene

  • Leucine Rich Repeat Containing 37A 2 3 5
  • Leucine-Rich Repeat-Containing Protein 37A 3 4
  • KIAA0563 2
  • LRRC37A1 4
  • LRRC37A 5
  • LRRC37 3

External Ids for LRRC37A Gene

Previous GeneCards Identifiers for LRRC37A Gene

  • GC17P041733
  • GC17P044370
  • GC17P046239

Summaries for LRRC37A Gene

GeneCards Summary for LRRC37A Gene

LRRC37A (Leucine Rich Repeat Containing 37A) is a Protein Coding gene. Diseases associated with LRRC37A include Koolen-De Vries Syndrome and Supranuclear Palsy, Progressive, 1. An important paralog of this gene is LRRC37A2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC37A Gene

Genomics for LRRC37A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC37A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC37A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC37A

Top Transcription factor binding sites by QIAGEN in the LRRC37A gene promoter:
  • Brachyury
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Pax-2
  • Pax-2a

Genomic Locations for LRRC37A Gene

Latest Assembly
chr17:46,292,733-46,337,794
(GRCh38/hg38)
Size:
45,062 bases
Orientation:
Plus strand

Previous Assembly
chr17:44,372,497-44,415,160
(GRCh37/hg19 by Entrez Gene)
Size:
42,664 bases
Orientation:
Plus strand

chr17:44,370,099-44,415,160
(GRCh37/hg19 by Ensembl)
Size:
45,062 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):413,631-456,611 (-)

Genomic View for LRRC37A Gene

Genes around LRRC37A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37A Gene

Proteins for LRRC37A Gene

  • Protein details for LRRC37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMS7-L37A1_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 37A
    Protein Accession:
    A6NMS7
    Secondary Accessions:
    • Q68DY2
    • Q8IWC7

    Protein attributes for LRRC37A Gene

    Size:
    1700 amino acids
    Molecular mass:
    188258 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH18088.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for LRRC37A Gene

Post-translational modifications for LRRC37A Gene

  • Glycosylation at Asn296 and Asn1079
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC37A Gene

No data available for DME Specific Peptides for LRRC37A Gene

Domains & Families for LRRC37A Gene

Gene Families for LRRC37A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LRRC37A Gene

Suggested Antigen Peptide Sequences for LRRC37A Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 37A (L37A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMS7

UniProtKB/Swiss-Prot:

L37A1_HUMAN :
  • Belongs to the LRRC37A family.
Family:
  • Belongs to the LRRC37A family.
genes like me logo Genes that share domains with LRRC37A: view

Function for LRRC37A Gene

Phenotypes From GWAS Catalog for LRRC37A Gene

Gene Ontology (GO) - Molecular Function for LRRC37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC37A: view
genes like me logo Genes that share phenotypes with LRRC37A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC37A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37A Gene

Localization for LRRC37A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37A Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC37A gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37A: view

Pathways & Interactions for LRRC37A Gene

PathCards logo

SuperPathways for LRRC37A Gene

No Data Available

Interacting Proteins for LRRC37A Gene

Gene Ontology (GO) - Biological Process for LRRC37A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC37A Gene

Drugs & Compounds for LRRC37A Gene

No Compound Related Data Available

Transcripts for LRRC37A Gene

mRNA/cDNA for LRRC37A Gene

1 REFSEQ mRNAs :
45 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC37A

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37A Gene

No ASD Table

Relevant External Links for LRRC37A Gene

GeneLoc Exon Structure for
LRRC37A

Expression for LRRC37A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC37A Gene

mRNA differential expression in normal tissues according to GTEx for LRRC37A Gene

This gene is overexpressed in Testis (x4.5).

Protein differential expression in normal tissues from HIPED for LRRC37A Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC37A Gene



Protein tissue co-expression partners for LRRC37A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC37A

SOURCE GeneReport for Unigene cluster for LRRC37A Gene:

Hs.579108

Evidence on tissue expression from TISSUES for LRRC37A Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with LRRC37A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37A Gene

Orthologs for LRRC37A Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC37A3 29
  • 95.69 (n)
-- 30
  • 92 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 48 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 48 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm884 30
  • 32 (a)
ManyToMany
Lrrc37a 30
  • 16 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 22 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 22 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 44 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 27 (a)
OneToMany
Species where no ortholog for LRRC37A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LRRC37A Gene

ENSEMBL:
Gene Tree for LRRC37A (if available)
TreeFam:
Gene Tree for LRRC37A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC37A: view image
Alliance of Genome Resources:
Additional Orthologs for LRRC37A

Paralogs for LRRC37A Gene

Paralogs for LRRC37A Gene

(5) SIMAP similar genes for LRRC37A Gene using alignment to 3 proteins:

  • L37A1_HUMAN
  • A8MUI5_HUMAN
  • E9PP10_HUMAN

Pseudogenes.org Pseudogenes for LRRC37A Gene

genes like me logo Genes that share paralogs with LRRC37A: view

Variants for LRRC37A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC37A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs62073222 Benign: not specified 46,297,344(+) A/G
NM_001103154.2(ARL17B):c.21+2182T>C
SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRC37A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRC37A Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv13n31 CNV gain 19718026
dgv29e213 CNV loss 24956385
dgv30e213 CNV gain 24956385
dgv3184n100 CNV gain 25217958
dgv3185n100 CNV gain 25217958
dgv3188n100 CNV gain 25217958
dgv3189n100 CNV gain 25217958
dgv3190n100 CNV gain 25217958
dgv3196n100 CNV gain+loss 25217958
dgv3198n100 CNV loss 25217958
dgv3206n100 CNV loss 25217958
dgv3209n100 CNV gain 25217958
dgv3214n100 CNV gain+loss 25217958
dgv3232n100 CNV loss 25217958
dgv3233n100 CNV gain 25217958
dgv3238n100 CNV gain 25217958
dgv3239n100 CNV gain 25217958
dgv3240n100 CNV gain 25217958
dgv3241n100 CNV loss 25217958
dgv3242n100 CNV gain+loss 25217958
dgv3244n100 CNV loss 25217958
dgv3245n100 CNV gain+loss 25217958
dgv3246n100 CNV gain+loss 25217958
dgv3247n100 CNV gain 25217958
dgv3248n100 CNV loss 25217958
dgv3249n100 CNV gain 25217958
dgv3250n100 CNV gain+loss 25217958
dgv3251n100 CNV loss 25217958
dgv3252n100 CNV loss 25217958
dgv3253n100 CNV loss 25217958
dgv3254n100 CNV gain+loss 25217958
dgv3255n100 CNV gain 25217958
dgv5618n54 CNV gain 21841781
dgv5623n54 CNV loss 21841781
dgv5628n54 CNV loss 21841781
dgv5638n54 CNV gain 21841781
dgv5641n54 CNV loss 21841781
dgv5642n54 CNV loss 21841781
dgv5643n54 CNV gain 21841781
dgv5644n54 CNV gain 21841781
dgv5645n54 CNV loss 21841781
dgv5646n54 CNV gain+loss 21841781
dgv5647n54 CNV loss 21841781
dgv939e212 CNV gain 25503493
dgv940e212 CNV loss 25503493
esv1003686 CNV gain 20482838
esv21783 CNV gain+loss 19812545
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv2760451 CNV gain+loss 21179565
esv2762433 CNV gain+loss 21179565
esv33048 CNV gain+loss 17666407
esv3395024 CNV duplication 20981092
esv3444693 CNV duplication 20981092
esv3450287 CNV duplication 20981092
esv3584722 CNV loss 24956385
esv3893017 CNV gain+loss 25118596
esv3893020 CNV gain 25118596
esv3893022 CNV gain 25118596
esv3893023 CNV gain+loss 25118596
nsv1061687 CNV loss 25217958
nsv1063349 CNV gain 25217958
nsv1072741 CNV deletion 25765185
nsv1118761 CNV deletion 24896259
nsv1126463 CNV deletion 24896259
nsv1136238 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1160492 CNV duplication 26073780
nsv1160494 CNV deletion 26073780
nsv163 CNV deletion 15895083
nsv2070 CNV deletion 18451855
nsv428343 CNV gain+loss 18775914
nsv442749 CNV gain+loss 18776908
nsv469697 CNV gain+loss 16826518
nsv471698 CNV gain+loss 15918152
nsv511057 OTHER complex 20534489
nsv516807 CNV gain+loss 19592680
nsv575266 CNV gain 21841781
nsv575272 CNV loss 21841781
nsv821581 CNV deletion 20802225
nsv821687 CNV gain 15273396
nsv953912 CNV deletion 24416366
nsv9564 CNV gain+loss 18304495
nsv960494 CNV duplication 23825009

Variation tolerance for LRRC37A Gene

Gene Damage Index Score: 3.76; 57.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC37A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC37A
Leiden Open Variation Database (LOVD)
LRRC37A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37A Gene

Disorders for LRRC37A Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC37A Gene - From: COP

Disorder Aliases PubMed IDs
koolen-de vries syndrome
  • kdvs
supranuclear palsy, progressive, 1
  • psnp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC37A

genes like me logo Genes that share disorders with LRRC37A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC37A Gene

Publications for LRRC37A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Structural evolution of the BRCA1 genomic region in primates. (PMID: 15533724) Jin H … Roberts RG (Genomics 2004) 2 3
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G … Eichler EE (Genome research 2013) 3

Products for LRRC37A Gene

Sources for LRRC37A Gene