Aliases for LRRC36 Gene

Aliases for LRRC36 Gene

  • Leucine Rich Repeat Containing 36 2 3 5
  • Leucine-Rich Repeat-Containing Protein 36 3 4
  • RORBP70 3 4
  • ROR Gamma Binding Protein 70 3
  • ROR Gamma-Binding Protein 70 4
  • Heat Shock Regulated 2 3
  • XLHSRF2 3

External Ids for LRRC36 Gene

Previous GeneCards Identifiers for LRRC36 Gene

  • GC16P065919
  • GC16P053233

Summaries for LRRC36 Gene

GeneCards Summary for LRRC36 Gene

LRRC36 (Leucine Rich Repeat Containing 36) is a Protein Coding gene. Diseases associated with LRRC36 include Nemaline Myopathy 2. An important paralog of this gene is CEP72.

Additional gene information for LRRC36 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC36 Gene

Genomics for LRRC36 Gene

GeneHancer (GH) Regulatory Elements for LRRC36 Gene

Promoters and enhancers for LRRC36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067326 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 516.6 0.0 -48 1.7 CTCF PHF8 PHB2 ZBTB10 ZBTB26 CTBP1 ZBTB7A TRIM22 SMC3 ZNF341 LRRC36 HSALNG0112196 KCTD19 lnc-FHOD1-2 RN7SKP118 lnc-TPPP3-2
GH16J067345 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 517.2 +19.5 19538 2.5 TCF12 EP300 CEBPB JUN GATA3 FOXA1 FOS RFX5 STAT3 RXRA LRRC36 ATP6V0D1 RNU1-123P TPPP3 PLEKHG4 ZDHHC1 HSD11B2 LRRC29 TMEM208 ELMO3
GH16J067327 Promoter 0.6 Ensembl 517.5 +1.1 1103 0.2 ESRRA IKZF1 PRDM1 LRRC36 HSALNG0112196 KCTD19 lnc-FHOD1-2 RF00003-031 RNU1-123P
GH16J067413 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.1 +88.2 88236 4.1 CTCF POLR2G PHF8 ZNF10 ZIC2 POLR2A ZBTB26 REST ZBTB7A SKI ZDHHC1 lnc-ZDHHC1-1 TPPP3 PRMT7 ATP6V0D1 LRRC36 FHOD1 PLEKHG4 LRRC29 TMEM208
GH16J067389 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.1 +68.6 68610 12.4 EP300 CTCF TEAD4 ZNF10 ZIC2 REST ZBTB11 TAF7 GABPA KLF4 TPPP3 lnc-TPPP3-1 LRRC36 ATP6V0D1 FHOD1 ZDHHC1 HSD11B2 PLEKHG4 ENSG00000260465 PRMT7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC36 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC36

Top Transcription factor binding sites by QIAGEN in the LRRC36 gene promoter:
  • FOXD3
  • FOXI1
  • FOXL1
  • HFH-3
  • NF-1
  • Pax-5
  • RP58
  • Sox5
  • SRF
  • SRF (504 AA)

Genomic Locations for LRRC36 Gene

Genomic Locations for LRRC36 Gene
chr16:67,326,798-67,385,206
(GRCh38/hg38)
Size:
58,409 bases
Orientation:
Plus strand
chr16:67,360,701-67,419,109
(GRCh37/hg19)
Size:
58,409 bases
Orientation:
Plus strand

Genomic View for LRRC36 Gene

Genes around LRRC36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC36 Gene

Proteins for LRRC36 Gene

  • Protein details for LRRC36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1X8D7-LRC36_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 36
    Protein Accession:
    Q1X8D7
    Secondary Accessions:
    • A4FTV6
    • A6NDE9
    • A8K8E6
    • B7Z7B3
    • Q7Z5K5

    Protein attributes for LRRC36 Gene

    Size:
    754 amino acids
    Molecular mass:
    83823 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC36 Gene

Post-translational modifications for LRRC36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC36 Gene

Domains & Families for LRRC36 Gene

Gene Families for LRRC36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC36 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC36 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50807, highly similar to Homo sapiens leucine rich repeat containing 36 (LRRC36), mRNA (B7Z4G3_HUMAN)
  • cDNA FLJ55796, highly similar to Homo sapiens leucine rich repeat containing 36 (LRRC36), mRNA (B7Z7B3_HUMAN)
  • ROR gamma-binding protein 70 (LRC36_HUMAN)
  • cDNA FLJ11004 fis, clone PLACE1002941 (Q9NV11_HUMAN)
genes like me logo Genes that share domains with LRRC36: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC36 Gene

Function for LRRC36 Gene

Phenotypes From GWAS Catalog for LRRC36 Gene

Phenotypes for LRRC36 Gene

genes like me logo Genes that share phenotypes with LRRC36: view

Animal Models for LRRC36 Gene

MGI Knock Outs for LRRC36:

Animal Model Products

CRISPR Products

miRNA for LRRC36 Gene

miRTarBase miRNAs that target LRRC36

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC36 Gene

Localization for LRRC36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC36 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC36 Gene

Pathways & Interactions for LRRC36 Gene

PathCards logo

SuperPathways for LRRC36 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC36 Gene

Drugs & Compounds for LRRC36 Gene

No Compound Related Data Available

Transcripts for LRRC36 Gene

mRNA/cDNA for LRRC36 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14:

ExUns: 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

Relevant External Links for LRRC36 Gene

GeneLoc Exon Structure for
LRRC36

Expression for LRRC36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC36 Gene

This gene is overexpressed in Testis (x29.3) and Lung (x4.9).

Protein differential expression in normal tissues from HIPED for LRRC36 Gene

This gene is overexpressed in Colon muscle (35.2), Tlymphocyte (19.0), and Testis (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC36 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC36

SOURCE GeneReport for Unigene cluster for LRRC36 Gene:

Hs.125139
genes like me logo Genes that share expression patterns with LRRC36: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC36 Gene

Orthologs for LRRC36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC36 31 30
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC36 31 30
  • 90.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC36 31 30
  • 89.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc36 30
  • 86.03 (n)
mouse
(Mus musculus)
Mammalia Lrrc36 17 31 30
  • 85.54 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC36 31
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC36 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc36 30
  • 47.75 (n)
Species where no ortholog for LRRC36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC36 Gene

ENSEMBL:
Gene Tree for LRRC36 (if available)
TreeFam:
Gene Tree for LRRC36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC36: view image

Paralogs for LRRC36 Gene

Paralogs for LRRC36 Gene

(35) SIMAP similar genes for LRRC36 Gene using alignment to 13 proteins:

  • LRC36_HUMAN
  • B7Z4G3_HUMAN
  • B7Z7B3_HUMAN
  • H3BND7_HUMAN
  • H3BNV0_HUMAN
  • H3BQI9_HUMAN
  • H3BRB2_HUMAN
  • H3BRP7_HUMAN
  • H3BS33_HUMAN
  • H3BSQ6_HUMAN
  • J3QRT0_HUMAN
  • J3QSG3_HUMAN
  • Q9NV11_HUMAN
genes like me logo Genes that share paralogs with LRRC36: view

Variants for LRRC36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC36 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs16957415 - p.Ser744Gly
rs8052655 - p.Gly509Ser
rs9922085 - p.Arg222Pro

Additional dbSNP identifiers (rs#s) for LRRC36 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC36 Gene

Variant ID Type Subtype PubMed ID
esv3638884 CNV loss 21293372
esv3638885 CNV loss 21293372
nsv1116155 CNV deletion 24896259
nsv1841 CNV insertion 18451855
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv572906 CNV loss 21841781
nsv833265 CNV loss 17160897
nsv952045 CNV deletion 24416366

Variation tolerance for LRRC36 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.84; 95.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC36 Gene

Human Gene Mutation Database (HGMD)
LRRC36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC36 Gene

Disorders for LRRC36 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC36 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nemaline myopathy 2
  • nem2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC36

genes like me logo Genes that share disorders with LRRC36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC36 Gene

Publications for LRRC36 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 41 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for LRRC36 Gene

Sources for LRRC36 Gene