This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008] See more...

Aliases for LRRC32 Gene

Aliases for LRRC32 Gene

  • Leucine Rich Repeat Containing 32 2 3 5
  • Glycoprotein A Repetitions Predominant 2 3 4
  • Transforming Growth Factor Beta Activator LRRC32 3 4
  • Leucine-Rich Repeat-Containing Protein 32 3 4
  • D11S833E 3 4
  • Garpin 3 4
  • GARP 3 4

External Ids for LRRC32 Gene

Previous HGNC Symbols for LRRC32 Gene

  • D11S833E
  • GARP

Previous GeneCards Identifiers for LRRC32 Gene

  • GC11M076047
  • GC11M076368
  • GC11M072666

Summaries for LRRC32 Gene

Entrez Gene Summary for LRRC32 Gene

  • This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRC32 Gene

LRRC32 (Leucine Rich Repeat Containing 32) is a Protein Coding gene. An important paralog of this gene is NRROS.

UniProtKB/Swiss-Prot Summary for LRRC32 Gene

  • Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).

Additional gene information for LRRC32 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC32 Gene

Genomics for LRRC32 Gene

GeneHancer (GH) Regulatory Elements for LRRC32 Gene


GeneHancers around LRRC32 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC32

Top Transcription factor binding sites by QIAGEN in the LRRC32 gene promoter:
  • c-Myb
  • c-Myc
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for LRRC32 Gene

Genomic Locations for LRRC32 Gene
chr11:76,657,524-76,670,946
(GRCh38/hg38)
Size:
13,423 bases
Orientation:
Minus strand
chr11:76,368,568-76,381,791
(GRCh37/hg19)
Size:
13,224 bases
Orientation:
Minus strand

Genomic View for LRRC32 Gene

Genes around LRRC32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC32 Gene

Proteins for LRRC32 Gene

  • Protein details for LRRC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14392-LRC32_HUMAN
    Recommended name:
    Transforming growth factor beta activator LRRC32
    Protein Accession:
    Q14392
    Secondary Accessions:
    • Q86V06

    Protein attributes for LRRC32 Gene

    Size:
    662 amino acids
    Molecular mass:
    71979 Da
    Quaternary structure:
    • Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (PubMed:19651619, PubMed:22278742). Interacts with TGFB2 (PubMed:19651619). Interacts with TGFB3; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB3, leading to regulate activation of TGF-beta-3 (By similarity). Interacts with LAPTM4B; decreases TGFB1 production in regulatory T-cells (PubMed:26126825).
    SequenceCaution:
    • Sequence=AAH52210.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LRRC32 Gene

neXtProt entry for LRRC32 Gene

Post-translational modifications for LRRC32 Gene

  • Glycosylation at Asn203, Asn271, Asn308, Asn345, and Asn545
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LRRC32
  • Boster Bio Antibodies for LRRC32

No data available for DME Specific Peptides for LRRC32 Gene

Domains & Families for LRRC32 Gene

Gene Families for LRRC32 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRRC32 Gene

Blocks:
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC32 Gene

GenScript: Design optimal peptide antigens:
  • Glycoprotein A repetitions predominant (LRC32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14392

UniProtKB/Swiss-Prot:

LRC32_HUMAN :
  • Belongs to the LRRC32/LRRC33 family.
Family:
  • Belongs to the LRRC32/LRRC33 family.
genes like me logo Genes that share domains with LRRC32: view

Function for LRRC32 Gene

Molecular function for LRRC32 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).

Phenotypes From GWAS Catalog for LRRC32 Gene

Gene Ontology (GO) - Molecular Function for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19651619
GO:0019838 growth factor binding IEA --
GO:0050431 transforming growth factor beta binding IPI 19651619
genes like me logo Genes that share ontologies with LRRC32: view
genes like me logo Genes that share phenotypes with LRRC32: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC32 Gene

Localization for LRRC32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC32 Gene

Cell membrane; Single-pass type I membrane protein. Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC32 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 4
golgi apparatus 3
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8180135
GO:0009986 cell surface IDA,IEA 19651619
genes like me logo Genes that share ontologies with LRRC32: view

Pathways & Interactions for LRRC32 Gene

PathCards logo

SuperPathways for LRRC32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 19750484
GO:0010628 positive regulation of gene expression IEA --
GO:0046007 negative regulation of activated T cell proliferation IEA --
GO:0050710 negative regulation of cytokine secretion IEA --
GO:0062009 secondary palate development ISS --
genes like me logo Genes that share ontologies with LRRC32: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC32 Gene

Drugs & Compounds for LRRC32 Gene

No Compound Related Data Available

Transcripts for LRRC32 Gene

mRNA/cDNA for LRRC32 Gene

7 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for LRRC32 Gene

GeneLoc Exon Structure for
LRRC32

Expression for LRRC32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC32 Gene

Protein differential expression in normal tissues from HIPED for LRRC32 Gene

This gene is overexpressed in Serum (41.8) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC32 Gene



Protein tissue co-expression partners for LRRC32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC32

SOURCE GeneReport for Unigene cluster for LRRC32 Gene:

Hs.151641

mRNA Expression by UniProt/SwissProt for LRRC32 Gene:

Q14392-LRC32_HUMAN
Tissue specificity: Preferentially expressed in regulatory T-cells (Tregs).

Evidence on tissue expression from TISSUES for LRRC32 Gene

  • Liver(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with LRRC32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC32 Gene

Orthologs for LRRC32 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC32 31 30
  • 99.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC32 31 30
  • 86.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC32 31 30
  • 86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc32 30
  • 81.57 (n)
mouse
(Mus musculus)
Mammalia Lrrc32 17 31 30
  • 81 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC32 31
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC32 31 30
  • 52.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC32 31
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc32 30
  • 50.27 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148867 30
  • 53.16 (n)
lrrc32 31
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 31
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 31
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 17 (a)
ManyToMany
Species where no ortholog for LRRC32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC32 Gene

ENSEMBL:
Gene Tree for LRRC32 (if available)
TreeFam:
Gene Tree for LRRC32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC32: view image

Paralogs for LRRC32 Gene

(3) SIMAP similar genes for LRRC32 Gene using alignment to 2 proteins:

  • LRC32_HUMAN
  • C9JYU3_HUMAN
genes like me logo Genes that share paralogs with LRRC32: view

Variants for LRRC32 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC32 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
723320 Benign: not provided 76,660,273(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
790648 Benign: not provided 76,661,219(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs369867819 Likely Pathogenic: Cleft palate; Global developmental delay; Vitreoretinopathy 76,659,963(-) G/A NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs35033061 - p.Leu223Val
rs35130967 - p.Gly311Ala

Additional dbSNP identifiers (rs#s) for LRRC32 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC32 Gene

Variant ID Type Subtype PubMed ID
dgv1228n100 CNV loss 25217958
nsv1047069 CNV gain 25217958
nsv555448 CNV gain 21841781

Variation tolerance for LRRC32 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC32 Gene

Human Gene Mutation Database (HGMD)
LRRC32
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC32 Gene

Disorders for LRRC32 Gene

Additional Disease Information for LRRC32

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRC32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC32 Gene

Publications for LRRC32 Gene

  1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PMID: 8180135) Ollendorff V … Birnbaum D (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994) 2 3 4 23 54
  2. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PMID: 19651619) Tran DQ … Shevach EM (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 23 54
  3. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. (PMID: 18628982) Wang R … Unutmaz D (PloS one 2008) 3 4 23 54
  4. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells. (PMID: 26126825) Huygens C … Lucas S (The Journal of biological chemistry 2015) 3 4 54
  5. GARP regulates the bioavailability and activation of TGFβ. (PMID: 22278742) Wang R … Springer TA (Molecular biology of the cell 2012) 3 4 54

Products for LRRC32 Gene

Sources for LRRC32 Gene