Aliases for LRRC3 Gene

Aliases for LRRC3 Gene

  • Leucine Rich Repeat Containing 3 2 3 5
  • LRRC3 Downstream Neighbor (Non-Protein Coding) 2 3
  • Leucine-Rich Repeat-Containing Protein 3 3 4
  • C21orf102 3 4
  • Chromosome 21 Open Reading Frame 102 2
  • Chromosome 21 Open Reading Frame 30 2
  • Intronless Long ORF, AL117578 3
  • LRRC3 Downstream Neighbor 2
  • DKFZP434C128 2
  • C21orf30 3
  • LRRC3DN 3
  • LRRC3A 4
  • LRRC3 5

External Ids for LRRC3 Gene

Previous HGNC Symbols for LRRC3 Gene

  • C21orf102
  • LRRC3DN
  • C21orf30

Previous GeneCards Identifiers for LRRC3 Gene

  • GC21P042386
  • GC21P044732
  • GC21P044699
  • GC21P045875
  • GC21P031231

Summaries for LRRC3 Gene

GeneCards Summary for LRRC3 Gene

LRRC3 (Leucine Rich Repeat Containing 3) is a Protein Coding gene. Diseases associated with LRRC3 include Indolent Myeloma and Osteogenesis Imperfecta, Type Iv. An important paralog of this gene is LRRC3B.

Additional gene information for LRRC3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC3 Gene

Genomics for LRRC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC3

Top Transcription factor binding sites by QIAGEN in the LRRC3 gene promoter:
  • AML1a
  • E47
  • FAC1
  • HOXA9
  • HOXA9B
  • Lmo2
  • Meis-1
  • Meis-1a
  • p53
  • Tal-1

Genomic Locations for LRRC3 Gene

Genomic Locations for LRRC3 Gene
chr21:44,455,510-44,462,196
(GRCh38/hg38)
Size:
6,687 bases
Orientation:
Plus strand
chr21:45,875,369-45,878,739
(GRCh37/hg19)
Size:
3,371 bases
Orientation:
Plus strand

Genomic View for LRRC3 Gene

Genes around LRRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC3 Gene

Proteins for LRRC3 Gene

  • Protein details for LRRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY71-LRRC3_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 3
    Protein Accession:
    Q9BY71
    Secondary Accessions:
    • Q0VDJ2

    Protein attributes for LRRC3 Gene

    Size:
    257 amino acids
    Molecular mass:
    28108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC3 Gene

Post-translational modifications for LRRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC3 Gene

Domains & Families for LRRC3 Gene

Gene Families for LRRC3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for LRRC3 Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC3 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 3 (LRRC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BY71

UniProtKB/Swiss-Prot:

LRRC3_HUMAN :
  • Belongs to the LRRC3 family.
Family:
  • Belongs to the LRRC3 family.
genes like me logo Genes that share domains with LRRC3: view

Function for LRRC3 Gene

Phenotypes From GWAS Catalog for LRRC3 Gene

Gene Ontology (GO) - Molecular Function for LRRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with LRRC3: view
genes like me logo Genes that share phenotypes with LRRC3: view

Animal Models for LRRC3 Gene

MGI Knock Outs for LRRC3:
  • Lrrc3 Lrrc3<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC3 Gene

Localization for LRRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC3 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC3 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1
lysosome 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for LRRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRRC3 Gene

Pathways & Interactions for LRRC3 Gene

PathCards logo

SuperPathways for LRRC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC3 Gene

Drugs & Compounds for LRRC3 Gene

No Compound Related Data Available

Transcripts for LRRC3 Gene

mRNA/cDNA for LRRC3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC3

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC3 Gene

No ASD Table

Relevant External Links for LRRC3 Gene

GeneLoc Exon Structure for
LRRC3

Expression for LRRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC3 Gene

This gene is overexpressed in Liver (x6.8).

Protein differential expression in normal tissues from HIPED for LRRC3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC3 Gene



Protein tissue co-expression partners for LRRC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC3

SOURCE GeneReport for Unigene cluster for LRRC3 Gene:

Hs.326579

mRNA Expression by UniProt/SwissProt for LRRC3 Gene:

Q9BY71-LRRC3_HUMAN
Tissue specificity: Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.

Evidence on tissue expression from TISSUES for LRRC3 Gene

  • Liver(2.3)
genes like me logo Genes that share expression patterns with LRRC3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC3 Gene

Orthologs for LRRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC3 30 31
  • 99.09 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC3 30 31
  • 86.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRC3 30 31
  • 85.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc3 30
  • 81.73 (n)
Mouse
(Mus musculus)
Mammalia Lrrc3 30 17 31
  • 79.64 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRRC3 31
  • 59 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC3 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492333 30
  • 65.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii lrrc3 30 31
  • 61.97 (n)
OneToOne
Species where no ortholog for LRRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRRC3 Gene

ENSEMBL:
Gene Tree for LRRC3 (if available)
TreeFam:
Gene Tree for LRRC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC3: view image

Paralogs for LRRC3 Gene

(2) SIMAP similar genes for LRRC3 Gene using alignment to 1 proteins:

  • LRRC3_HUMAN
genes like me logo Genes that share paralogs with LRRC3: view

Variants for LRRC3 Gene

Additional dbSNP identifiers (rs#s) for LRRC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC3 Gene

Variant ID Type Subtype PubMed ID
dgv722n67 CNV gain 20364138
esv2723638 CNV deletion 23290073
esv33817 CNV loss 17666407
nsv1058359 CNV gain 25217958
nsv1122046 CNV deletion 24896259
nsv509800 CNV insertion 20534489
nsv587801 CNV loss 21841781
nsv834109 CNV loss 17160897
nsv953646 CNV deletion 24416366

Variation tolerance for LRRC3 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC3 Gene

Human Gene Mutation Database (HGMD)
LRRC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC3 Gene

Disorders for LRRC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
indolent myeloma
  • indolent multiple myeloma
osteogenesis imperfecta, type iv
  • oi4
- elite association - COSMIC cancer census association via MalaCards
Search LRRC3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with LRRC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC3 Gene

Publications for LRRC3 Gene

  1. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A … Antonarakis SE (Genomics 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PMID: 20494980) Warnatz HJ … Yaspo ML (Nucleic acids research 2010) 3

Products for LRRC3 Gene

Sources for LRRC3 Gene