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Aliases for LRRC28 Gene

Aliases for LRRC28 Gene

  • Leucine Rich Repeat Containing 28 2 3 5

External Ids for LRRC28 Gene

Previous GeneCards Identifiers for LRRC28 Gene

  • GC15P097527
  • GC15P097609
  • GC15P099791
  • GC15P075921

Summaries for LRRC28 Gene

GeneCards Summary for LRRC28 Gene

LRRC28 (Leucine Rich Repeat Containing 28) is a Protein Coding gene. An important paralog of this gene is LRRC8E.

Additional gene information for LRRC28 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC28 Gene

Genomics for LRRC28 Gene

GeneHancer (GH) Regulatory Elements for LRRC28 Gene

Promoters and enhancers for LRRC28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I099248 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 559.6 -1.0 -986 4.5 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TTC23 LRRC28 PIR36219 SYNM GC15M099193
GH15I099731 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.6 +481.9 481917 4 HDGF FOXA2 ARNT SIN3A ZNF48 GLIS2 ELK1 ZNF207 SP3 RXRA LYSMD4 LRRC28 TTC23 DNM1P46 ENSG00000201724 GC15M099683
GH15I099167 Enhancer 1 Ensembl ENCODE dbSUPER 15.7 -82.0 -81971 4.7 CTCF ZNF687 EBF1 RELA POLR2A SCRT2 IKZF1 RUNX3 IKZF2 SPI1 SYNM LRRC28 ENSG00000261616 ENSG00000261054 TTC23 ENSG00000259921 GC15M099193
GH15I099276 Enhancer 0.7 dbSUPER 20.4 +25.8 25808 2.3 PKNOX1 L3MBTL2 OSR2 ZFP69B ZNF335 PRDM6 ZNF610 ZNF692 ZBTB48 GLIS1 TTC23 LRRC28 MEF2A SYNM HNRNPA1P62 HSP90B2P
GH15I099104 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.6 -145.0 -145043 3.8 HDGF ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF143 RUNX3 SP3 NFYC SYNM LOC105371016 PIR44206 ENSG00000261616 TTC23 LRRC28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC28 gene promoter:

Genomic Locations for LRRC28 Gene

Genomic Locations for LRRC28 Gene
139,368 bases
Plus strand

Genomic View for LRRC28 Gene

Genes around LRRC28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC28 Gene

Proteins for LRRC28 Gene

  • Protein details for LRRC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 28
    Protein Accession:
    Secondary Accessions:
    • A8KA22
    • Q6UY49
    • Q6ZSS6

    Protein attributes for LRRC28 Gene

    367 amino acids
    Molecular mass:
    41912 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC28 Gene


neXtProt entry for LRRC28 Gene

Post-translational modifications for LRRC28 Gene

  • Ubiquitination at isoforms=2134, isoforms=2, 3217, posLast=226226, and isoforms=2, 3243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC28 Gene

Domains & Families for LRRC28 Gene

Gene Families for LRRC28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC28: view

No data available for UniProtKB/Swiss-Prot for LRRC28 Gene

Function for LRRC28 Gene

Phenotypes From GWAS Catalog for LRRC28 Gene

Phenotypes for LRRC28 Gene

GenomeRNAi human phenotypes for LRRC28:
genes like me logo Genes that share phenotypes with LRRC28: view

Animal Model Products

miRNA for LRRC28 Gene

miRTarBase miRNAs that target LRRC28

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC28 Gene

Localization for LRRC28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC28 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 NOT plasma membrane IBA --
genes like me logo Genes that share ontologies with LRRC28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC28 Gene

Pathways & Interactions for LRRC28 Gene

SuperPathways for LRRC28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with LRRC28: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC28 Gene

Drugs & Compounds for LRRC28 Gene

No Compound Related Data Available

Transcripts for LRRC28 Gene

Unigene Clusters for LRRC28 Gene

Leucine rich repeat containing 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC28 Gene

No ASD Table

Relevant External Links for LRRC28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC28 Gene

Protein differential expression in normal tissues from HIPED for LRRC28 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC28 Gene

Protein tissue co-expression partners for LRRC28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC28 Gene:


SOURCE GeneReport for Unigene cluster for LRRC28 Gene:


Evidence on tissue expression from TISSUES for LRRC28 Gene

  • Gall bladder(2.5)
genes like me logo Genes that share expression patterns with LRRC28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC28 Gene

Orthologs for LRRC28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC28 33 34
  • 99.18 (n)
(Canis familiaris)
Mammalia LRRC28 33 34
  • 93.19 (n)
(Monodelphis domestica)
Mammalia LRRC28 34
  • 93 (a)
(Bos Taurus)
Mammalia LRRC28 33 34
  • 92.64 (n)
(Ornithorhynchus anatinus)
Mammalia LRRC28 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Lrrc28 33
  • 88.34 (n)
(Mus musculus)
Mammalia Lrrc28 33 16 34
  • 88.16 (n)
(Gallus gallus)
Aves LRRC28 33 34
  • 76.16 (n)
(Anolis carolinensis)
Reptilia LRRC28 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc28 33
  • 73.02 (n)
Str.4116 33
(Danio rerio)
Actinopterygii lrrc28 33 34
  • 67.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for LRRC28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC28 Gene

Gene Tree for LRRC28 (if available)
Gene Tree for LRRC28 (if available)

Paralogs for LRRC28 Gene

Paralogs for LRRC28 Gene Pseudogenes for LRRC28 Gene

genes like me logo Genes that share paralogs with LRRC28: view

Variants for LRRC28 Gene

Sequence variations from dbSNP and Humsavar for LRRC28 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000021121 -- 99,250,649(+) C/T upstream_transcript_variant
rs1000038361 -- 99,266,152(+) C/G intron_variant
rs1000064350 -- 99,260,721(+) T/C intron_variant
rs1000068749 -- 99,385,311(+) GGGGG/GGGG 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000069020 -- 99,272,037(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC28 Gene

Variant ID Type Subtype PubMed ID
esv3379003 CNV insertion 20981092
esv3637424 CNV gain 21293372
esv3637426 CNV loss 21293372
esv3637427 CNV loss 21293372
esv3892741 CNV gain 25118596
nsv1045124 CNV gain 25217958
nsv1051560 CNV gain 25217958
nsv1055008 CNV gain 25217958
nsv1134487 CNV deletion 24896259
nsv516288 CNV loss 19592680
nsv570716 CNV gain 21841781
nsv977759 CNV duplication 23825009
nsv977760 CNV duplication 23825009

Variation tolerance for LRRC28 Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC28 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC28 Gene

Disorders for LRRC28 Gene

Additional Disease Information for LRRC28

No disorders were found for LRRC28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC28 Gene

Publications for LRRC28 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for LRRC28 Gene

Sources for LRRC28 Gene

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