Aliases for LRRC28 Gene
External Ids for LRRC28 Gene
- HGNC: 28355
- Entrez Gene: 123355
- Ensembl: ENSG00000168904
- UniProtKB: Q86X40
Previous GeneCards Identifiers for LRRC28 Gene
- GC15P097527
- GC15P097609
- GC15P099791
- GC15P075921
Summaries for LRRC28 Gene
GeneCards Summary for LRRC28 Gene
LRRC28 (Leucine Rich Repeat Containing 28) is a Protein Coding gene. An important paralog of this gene is LRRC8E.
Additional gene information for LRRC28 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC28 Gene
Genomics for LRRC28 Gene
GeneHancer (GH) Regulatory Elements for LRRC28 Gene
Promoters and enhancers for LRRC28 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LRRC28 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LRRC28 gene promoter:
Regulatory Element Products
Genomic Locations for LRRC28 Gene
Genomic Locations for LRRC28 Gene
- chr15:99,251,362-99,390,729
- (GRCh38/hg38)
- Size:
- 139,368 bases
- Orientation:
- Plus strand
- chr15:99,791,567-99,930,934
- (GRCh37/hg19)
Genomic View for LRRC28 Gene
Genes around LRRC28 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.3 by Ensembl
- 15q26.3 by Entrez Gene
- 15q26.3 by HGNC
LRRC28 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LRRC28 Gene
Proteins for LRRC28 Gene
-
Protein details for LRRC28 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86X40-LRC28_HUMAN
- Recommended name:
- Leucine-rich repeat-containing protein 28
- Protein Accession:
- Q86X40
- A8KA22
- Q6UY49
- Q6ZSS6
Protein attributes for LRRC28 Gene
- Size:
- 367 amino acids
- Molecular mass:
- 41912 Da
- Quaternary structure:
- No Data Available
Protein Expression for LRRC28 Gene
Post-translational modifications for LRRC28 Gene
Other Protein References for LRRC28 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for LRRC28
- Novus Biologicals Antibodies for LRRC28
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- GeneTex LRRC28 antibody for LRRC28
Protein Products
-
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- Search GeneTex for Proteins for LRRC28
-
Abcam proteins for LRRC28
Assay Products
No data available for DME Specific Peptides for LRRC28 Gene
Domains & Families for LRRC28 Gene
Gene Families for LRRC28 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for LRRC28 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for LRRC28 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for LRRC28 Gene
Function for LRRC28 Gene
Phenotypes From GWAS Catalog for LRRC28 Gene
Phenotypes for LRRC28 Gene
- GenomeRNAi human phenotypes for LRRC28:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for LRRC28
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LRRC28 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LRRC28 gene
- Search ViGene Biosciences for LRRC28
CRISPR Products
-
OriGene CRISPR knockouts for LRRC28
- genomics-online: gRNA clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
- Applied Biological Materials CRISPR for LRRC28
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRC28
- GenScript: Design CRISPR guide RNA sequences for LRRC28
miRNA for LRRC28 Gene
- miRTarBase miRNAs that target LRRC28
miRNA Products
- Search ViGene Biosciences for LRRC28
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LRRC28
- Browse OriGene Inhibitory RNA Products For LRRC28
- genomics-online: shRNA clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LRRC28 gene
Clone Products
- Sino Biological Human cDNA Clone for LRRC28
- VectorBuilder custom plasmid, inducible vectors for LRRC28
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LRRC28
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LRRC28
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LRRC28
-
ViGene Biosciences adenoviral particle packaged cDNA for LRRC28 gene
-
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-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC28 Gene
Localization for LRRC28 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
- Golgi apparatus (2)
- Mitochondria (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | NOT plasma membrane | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC28 Gene
Pathways & Interactions for LRRC28 Gene
No Data Available
Interacting Proteins for LRRC28 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for LRRC28 Gene
Transcripts for LRRC28 Gene
mRNA/cDNA for LRRC28 Gene
- (13) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (139) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LRRC28 Gene
CRISPR Products
-
OriGene CRISPR knockouts for LRRC28
- genomics-online: gRNA clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
- Applied Biological Materials CRISPR for LRRC28
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRRC28
- GenScript: Design CRISPR guide RNA sequences for LRRC28
miRNA Products
- Search ViGene Biosciences for LRRC28
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LRRC28
- Browse OriGene Inhibitory RNA Products For LRRC28
- genomics-online: shRNA clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LRRC28 gene
Clone Products
- Sino Biological Human cDNA Clone for LRRC28
- VectorBuilder custom plasmid, inducible vectors for LRRC28
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LRRC28
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LRRC28
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LRRC28 Gene
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC28 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LRRC28 Gene:
LRRC28SOURCE GeneReport for Unigene cluster for LRRC28 Gene:
Hs.578684Evidence on tissue expression from TISSUES for LRRC28 Gene
- Gall bladder(2.5)
Primer Products
-
OriGene qPCR primer pairs for LRRC28
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC28 Gene
Orthologs for LRRC28 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LRRC28 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LRRC28 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LRRC28 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LRRC28 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LRRC28 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Lrrc28 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Lrrc28 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | LRRC28 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | LRRC28 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lrrc28 33 |
|
||
| Str.4116 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | lrrc28 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for LRRC28 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for LRRC28 Gene
(10) SIMAP similar genes for LRRC28 Gene using alignment to 12 proteins:
Pseudogenes.org Pseudogenes for LRRC28 Gene
Variants for LRRC28 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021121 | -- | 99,250,649(+) | C/T | upstream_transcript_variant | |
| rs1000038361 | -- | 99,266,152(+) | C/G | intron_variant | |
| rs1000064350 | -- | 99,260,721(+) | T/C | intron_variant | |
| rs1000068749 | -- | 99,385,311(+) | GGGGG/GGGG | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000069020 | -- | 99,272,037(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3379003 | CNV | insertion | 20981092 |
| esv3637424 | CNV | gain | 21293372 |
| esv3637426 | CNV | loss | 21293372 |
| esv3637427 | CNV | loss | 21293372 |
| esv3892741 | CNV | gain | 25118596 |
| nsv1045124 | CNV | gain | 25217958 |
| nsv1051560 | CNV | gain | 25217958 |
| nsv1055008 | CNV | gain | 25217958 |
| nsv1134487 | CNV | deletion | 24896259 |
| nsv516288 | CNV | loss | 19592680 |
| nsv570716 | CNV | gain | 21841781 |
| nsv977759 | CNV | duplication | 23825009 |
| nsv977760 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.74;
46.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LRRC28 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC28 Gene
Disorders for LRRC28 Gene
Additional Disease Information for LRRC28
No disorders were found for LRRC28 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC28 Gene
Publications for LRRC28 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
Products for LRRC28 Gene
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- Custom Antibody ServicesOriGene Antibodies for LRRC28
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for LRRC28
- VectorBuilder custom plasmid, inducible vectors for LRRC28
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LRRC28
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available LRRC28 related products ranked by validation data
- antibodies-online: Search results for available LRRC28 related products ranked by validation data
- antibodies-online: Search results for available LRRC28 related products ranked by validation data
- GeneTex LRRC28 antibody for LRRC28
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- ViGene Biosciences adenoviral particle packaged cDNA for LRRC28 gene
- ViGene Biosciences lentiviral particle packaged cDNA for LRRC28 gene
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- Search ViGene Biosciences for LRRC28
- Horizon Cell Lines for LRRC28
- genomics-online: cdna clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
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- Overview of 152 available LRRC28 gene related products
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- Overview of 152 available LRRC28 gene related products
- genomics-online: primer clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
- genomics-online: shRNA clones - Search results for 152 available LRRC28 gene related products
- Overview of 152 available LRRC28 gene related products
Sources for LRRC28 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
