Aliases for LRRC27 Gene

Aliases for LRRC27 Gene

  • Leucine Rich Repeat Containing 27 2 3 5
  • Leucine-Rich Repeat-Containing Protein 27 3 4
  • KIAA1674 2 4
  • Testicular Tissue Protein Li 108 3
  • LRRC27 5

External Ids for LRRC27 Gene

Previous GeneCards Identifiers for LRRC27 Gene

  • GC10P133581
  • GC10P133995
  • GC10P134145
  • GC10P127697

Summaries for LRRC27 Gene

GeneCards Summary for LRRC27 Gene

LRRC27 (Leucine Rich Repeat Containing 27) is a Protein Coding gene. An important paralog of this gene is LRRK1.

Additional gene information for LRRC27 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC27 Gene

Genomics for LRRC27 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC27 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC27

Top Transcription factor binding sites by QIAGEN in the LRRC27 gene promoter:
  • c-Rel
  • LUN-1
  • NF-kappaB
  • S8

Genomic Locations for LRRC27 Gene

Genomic Locations for LRRC27 Gene
chr10:132,330,063-132,381,508
(GRCh38/hg38)
Size:
51,446 bases
Orientation:
Plus strand
chr10:134,145,614-134,195,010
(GRCh37/hg19)
Size:
49,397 bases
Orientation:
Plus strand

Genomic View for LRRC27 Gene

Genes around LRRC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC27 Gene

Proteins for LRRC27 Gene

  • Protein details for LRRC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0I9-LRC27_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 27
    Protein Accession:
    Q9C0I9
    Secondary Accessions:
    • A6NE72
    • A6NJB4
    • A6NKD3
    • D3DRH0
    • Q5SZH6
    • Q5SZH8
    • Q5SZH9
    • Q86XT5
    • Q8N7C8
    • Q8NA21

    Protein attributes for LRRC27 Gene

    Size:
    530 amino acids
    Molecular mass:
    60089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21765.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC27 Gene

Post-translational modifications for LRRC27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC27 Gene

Domains & Families for LRRC27 Gene

Gene Families for LRRC27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC27 Gene

Suggested Antigen Peptide Sequences for LRRC27 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57733, highly similar to Leucine-rich repeat-containing protein 27 (B4DJ72_HUMAN)
  • cDNA FLJ58633, highly similar to Leucine-rich repeat-containing protein 27 (B4DW88_HUMAN)
  • Leucine-rich repeat-containing protein 27 (LRC27_HUMAN)
genes like me logo Genes that share domains with LRRC27: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC27 Gene

Function for LRRC27 Gene

Phenotypes From GWAS Catalog for LRRC27 Gene

Gene Ontology (GO) - Molecular Function for LRRC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC27: view
genes like me logo Genes that share phenotypes with LRRC27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC27

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC27 Gene

Localization for LRRC27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC27 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC27 Gene

Pathways & Interactions for LRRC27 Gene

PathCards logo

SuperPathways for LRRC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC27 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC27 Gene

Drugs & Compounds for LRRC27 Gene

No Compound Related Data Available

Transcripts for LRRC27 Gene

mRNA/cDNA for LRRC27 Gene

5 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC27

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC27 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - -
SP8: -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - - - - - - -
SP14: - - - -
SP15: - - -
SP16:
SP17:

ExUns: 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP1: - - - -
SP2:
SP3:
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for LRRC27 Gene

GeneLoc Exon Structure for
LRRC27

Expression for LRRC27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for LRRC27 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for LRRC27 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (50.1) and Peripheral blood mononuclear cells (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC27 Gene



Protein tissue co-expression partners for LRRC27 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC27

SOURCE GeneReport for Unigene cluster for LRRC27 Gene:

Hs.119897

Evidence on tissue expression from TISSUES for LRRC27 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with LRRC27: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC27 Gene

Orthologs for LRRC27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC27 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC27 30 31
  • 98.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRRC27 30 31
  • 71.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrrc27 30 17 31
  • 69.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC27 30 31
  • 68.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc27 30
  • 67.58 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia LRRC27 31
  • 38 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC27 31
  • 35 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc27 30
  • 49.65 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
OneToOne
Species where no ortholog for LRRC27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for LRRC27 Gene

ENSEMBL:
Gene Tree for LRRC27 (if available)
TreeFam:
Gene Tree for LRRC27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC27: view image

Paralogs for LRRC27 Gene

Variants for LRRC27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC27 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
712971 Benign: not provided 132,331,541(+) T/C MISSENSE_VARIANT
rs2474329 - p.Arg195Cys

Additional dbSNP identifiers (rs#s) for LRRC27 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC27 Gene

Variant ID Type Subtype PubMed ID
dgv117e201 CNV deletion 23290073
dgv121n27 CNV loss 19166990
dgv1458n54 CNV loss 21841781
dgv1459n54 CNV loss 21841781
dgv1460n54 CNV loss 21841781
esv1064958 CNV deletion 17803354
esv1253542 CNV deletion 17803354
esv1748190 CNV insertion 17803354
esv1988912 CNV deletion 18987734
esv24691 CNV loss 19812545
esv2619239 CNV insertion 19546169
esv2659727 CNV deletion 23128226
esv2664289 CNV deletion 23128226
esv26827 CNV gain+loss 19812545
esv2741065 CNV deletion 23290073
esv2743654 CNV deletion 23290073
esv2743655 CNV deletion 23290073
esv2743656 CNV deletion 23290073
esv2743657 CNV deletion 23290073
esv2743658 CNV deletion 23290073
esv2743659 CNV deletion 23290073
esv2743660 CNV deletion 23290073
esv2743661 CNV deletion 23290073
esv2743662 CNV deletion 23290073
esv2743665 CNV deletion 23290073
esv2743667 CNV deletion 23290073
esv2743668 CNV deletion 23290073
esv2743669 CNV deletion 23290073
esv2743670 CNV deletion 23290073
esv2743671 CNV deletion 23290073
esv2743672 CNV deletion 23290073
esv2761642 CNV gain 21179565
esv28271 CNV gain 19812545
esv2858124 CNV duplication 24192839
esv3259718 CNV deletion 24192839
esv3395712 CNV duplication 20981092
esv3547108 CNV deletion 23714750
esv3547111 CNV deletion 23714750
esv3547112 CNV deletion 23714750
esv3547113 CNV deletion 23714750
esv3577872 CNV gain 25503493
esv3624986 CNV gain 21293372
esv3624988 CNV gain 21293372
esv3624990 CNV gain 21293372
esv4951 CNV loss 18987735
esv5807 CNV loss 19470904
esv7038 CNV loss 19470904
esv7280 CNV loss 19470904
esv998312 CNV deletion 20482838
nsv1051555 CNV gain 25217958
nsv1052405 CNV gain 25217958
nsv1054569 CNV gain 25217958
nsv1054934 CNV gain 25217958
nsv1069099 CNV deletion 25765185
nsv1069527 CNV deletion 25765185
nsv1122575 CNV deletion 24896259
nsv1133163 CNV tandem duplication 24896259
nsv1141062 CNV deletion 24896259
nsv1141754 CNV insertion 24896259
nsv1147318 CNV deletion 26484159
nsv1152391 CNV deletion 26484159
nsv24027 CNV insertion 16902084
nsv24519 CNV deletion 16902084
nsv25370 CNV deletion 16902084
nsv467493 CNV loss 19166990
nsv552508 CNV loss 21841781
nsv552509 CNV loss 21841781
nsv552510 CNV gain 21841781
nsv552513 CNV loss 21841781
nsv552515 CNV loss 21841781
nsv552517 CNV loss 21841781
nsv7627 CNV insertion 18451855
nsv825656 CNV gain 20364138
nsv832031 CNV loss 17160897

Variation tolerance for LRRC27 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC27 Gene

Disorders for LRRC27 Gene

No disorders were found for LRRC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC27 Gene

Publications for LRRC27 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for LRRC27 Gene

Sources for LRRC27 Gene