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Aliases for LRRC26 Gene

Aliases for LRRC26 Gene

  • Leucine Rich Repeat Containing 26 2 3 5
  • BK Channel Auxiliary Gamma Subunit LRRC26 3 4
  • Cytokeratin-Associated Protein In Cancer 3 4
  • CAPC 3 4
  • BK Channel Auxilliary Gamma Subunit LRRC26 3
  • Leucine-Rich Repeat-Containing Protein 26 3
  • Cytokeratin Associated Protein 3
  • BA350O14.10 3

External Ids for LRRC26 Gene

Previous GeneCards Identifiers for LRRC26 Gene

  • GC09U900600
  • GC09M139184
  • GC09M140063
  • GC09M109523

Summaries for LRRC26 Gene

GeneCards Summary for LRRC26 Gene

LRRC26 (Leucine Rich Repeat Containing 26) is a Protein Coding gene. Diseases associated with LRRC26 include Suppression Of Tumorigenicity 12. Gene Ontology (GO) annotations related to this gene include potassium channel regulator activity. An important paralog of this gene is LRRC24.

UniProtKB/Swiss-Prot for LRRC26 Gene

  • Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

Additional gene information for LRRC26 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC26 Gene

Genomics for LRRC26 Gene

GeneHancer (GH) Regulatory Elements for LRRC26 Gene

Promoters and enhancers for LRRC26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137166 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -1.1 -1094 10.1 HDGF SIN3A ZNF2 ZBTB7B GLIS2 ZNF143 KLF7 SP3 REST GMEB1 ENSG00000261793 MIR3621 TMEM210 LRRC26 TPRN IL9RP1 TMEM203 NDOR1 GRIN1 DPP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC26 gene promoter:
  • MyoD
  • p53

Genomic Locations for LRRC26 Gene

Genomic Locations for LRRC26 Gene
chr9:137,168,758-137,170,051
(GRCh38/hg38)
Size:
1,294 bases
Orientation:
Minus strand
chr9:140,063,210-140,064,503
(GRCh37/hg19)
Size:
1,294 bases
Orientation:
Minus strand

Genomic View for LRRC26 Gene

Genes around LRRC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC26 Gene

Proteins for LRRC26 Gene

  • Protein details for LRRC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2I0M4-LRC26_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 26
    Protein Accession:
    Q2I0M4
    Secondary Accessions:
    • B9EIR7
    • C3RUL3
    • Q5VSG2

    Protein attributes for LRRC26 Gene

    Size:
    334 amino acids
    Molecular mass:
    34857 Da
    Quaternary structure:
    • Interacts with KCNMA1.

    Alternative splice isoforms for LRRC26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC26 Gene

Post-translational modifications for LRRC26 Gene

  • Glycosylation at posLast=147147
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC26 Gene

Domains & Families for LRRC26 Gene

Gene Families for LRRC26 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LRRC26 Gene

Suggested Antigen Peptide Sequences for LRRC26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2I0M4

UniProtKB/Swiss-Prot:

LRC26_HUMAN :
  • The transmembrane domain is necessary for interaction with KCNMA1.
Domain:
  • The transmembrane domain is necessary for interaction with KCNMA1.
genes like me logo Genes that share domains with LRRC26: view

Function for LRRC26 Gene

Molecular function for LRRC26 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

Gene Ontology (GO) - Molecular Function for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IDA 22547800
GO:0005515 protein binding IPI 20613726
GO:0015459 potassium channel regulator activity IDA 20613726
GO:0044325 ion channel binding IPI 22547800
GO:0099104 potassium channel activator activity IDA 22547800
genes like me logo Genes that share ontologies with LRRC26: view
genes like me logo Genes that share phenotypes with LRRC26: view

Animal Models for LRRC26 Gene

MGI Knock Outs for LRRC26:
  • Lrrc26 Lrrc26<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC26 Gene

Localization for LRRC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC26 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269 PubMed:15164053}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC26 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 4
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 22547800
GO:0008076 voltage-gated potassium channel complex IDA 20613726
genes like me logo Genes that share ontologies with LRRC26: view

Pathways & Interactions for LRRC26 Gene

SuperPathways for LRRC26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0071805 potassium ion transmembrane transport IDA 22547800
GO:1903818 positive regulation of voltage-gated potassium channel activity IDA 22547800
genes like me logo Genes that share ontologies with LRRC26: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC26 Gene

Drugs & Compounds for LRRC26 Gene

No Compound Related Data Available

Transcripts for LRRC26 Gene

mRNA/cDNA for LRRC26 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC26 Gene

Leucine rich repeat containing 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC26 Gene

No ASD Table

Relevant External Links for LRRC26 Gene

GeneLoc Exon Structure for
LRRC26
ECgene alternative splicing isoforms for
LRRC26

Expression for LRRC26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC26 Gene

This gene is overexpressed in Minor Salivary Gland (x27.5), Prostate (x10.6), and Colon - Transverse (x5.0).

Protein differential expression in normal tissues from HIPED for LRRC26 Gene

This gene is overexpressed in Milk (44.6) and Heart (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC26 Gene



Protein tissue co-expression partners for LRRC26 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC26 Gene:

LRRC26

SOURCE GeneReport for Unigene cluster for LRRC26 Gene:

Hs.669977

mRNA Expression by UniProt/SwissProt for LRRC26 Gene:

Q2I0M4-LRC26_HUMAN
Tissue specificity: Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.

Evidence on tissue expression from TISSUES for LRRC26 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LRRC26: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC26 Gene

Orthologs for LRRC26 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC26 34 33
  • 97.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC26 34 33
  • 81.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC26 34 33
  • 81.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc26 33
  • 72.14 (n)
mouse
(Mus musculus)
Mammalia Lrrc26 16 34 33
  • 71.46 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC26 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC26 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC26 34 33
  • 53.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC26 34
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kek4 34
  • 13 (a)
ManyToMany
kek6 34
  • 10 (a)
ManyToMany
kek2 34
  • 9 (a)
ManyToMany
kek1 34
  • 9 (a)
ManyToMany
kek5 34
  • 9 (a)
ManyToMany
kek3 34
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
ManyToMany
CSA.1672 34
  • 17 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
Species where no ortholog for LRRC26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC26 Gene

ENSEMBL:
Gene Tree for LRRC26 (if available)
TreeFam:
Gene Tree for LRRC26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC26: view image

Paralogs for LRRC26 Gene

Paralogs for LRRC26 Gene

(1) SIMAP similar genes for LRRC26 Gene using alignment to 1 proteins:

  • LRC26_HUMAN
genes like me logo Genes that share paralogs with LRRC26: view

Variants for LRRC26 Gene

Sequence variations from dbSNP and Humsavar for LRRC26 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000093890 -- 137,171,173(-) C/A/G/T upstream_transcript_variant
rs1000146335 -- 137,170,959(-) A/G upstream_transcript_variant
rs1001159501 -- 137,171,962(-) G/A upstream_transcript_variant
rs1002169460 -- 137,168,707(-) C/G downstream_transcript_variant
rs1002712150 -- 137,171,930(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC26 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
esv3622023 CNV gain 21293372
nsv1161918 CNV duplication 26073780
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616005 CNV loss 21841781
nsv616007 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for LRRC26 Gene

Gene Damage Index Score: 7.17; 80.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC26 Gene

Disorders for LRRC26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppression of tumorigenicity 12
  • st12
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC26

genes like me logo Genes that share disorders with LRRC26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC26 Gene

Publications for LRRC26 Gene

  1. BK potassium channel modulation by leucine-rich repeat-containing proteins. (PMID: 22547800) Yan J … Aldrich RW (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 4 58
  2. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. (PMID: 20613726) Yan J … Aldrich RW (Nature 2010) 3 4 58
  3. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. (PMID: 19250639) Anaganti S … Bera TK (Biochemical and biophysical research communications 2009) 3 4 58
  4. High expression of a cytokeratin-associated protein in many cancers. (PMID: 16585525) Egland KA … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 58
  5. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits. (PMID: 26009545) Li Q … Yan J (The Journal of general physiology 2015) 3 58

Products for LRRC26 Gene

Sources for LRRC26 Gene

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