Aliases for LRRC25 Gene
External Ids for LRRC25 Gene
Previous GeneCards Identifiers for LRRC25 Gene
GeneCards Summary for LRRC25 Gene
LRRC25 (Leucine Rich Repeat Containing 25) is a Protein Coding gene. Diseases associated with LRRC25 include Transient Global Amnesia.
UniProtKB/Swiss-Prot for LRRC25 Gene
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.