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Aliases for LRRC17 Gene

Aliases for LRRC17 Gene

  • Leucine Rich Repeat Containing 17 2 3 5
  • P37NB 3 4
  • Leucine-Rich Repeat-Containing Protein 17 3
  • 37 KDa Leucine-Rich Repeat (LRR) Protein 3

External Ids for LRRC17 Gene

Previous GeneCards Identifiers for LRRC17 Gene

  • GC07P102100
  • GC07P102113
  • GC07P102147
  • GC07P102340
  • GC07P102553
  • GC07P096915

Summaries for LRRC17 Gene

GeneCards Summary for LRRC17 Gene

LRRC17 (Leucine Rich Repeat Containing 17) is a Protein Coding gene. Diseases associated with LRRC17 include Neuroblastoma. An important paralog of this gene is LRRC3.

UniProtKB/Swiss-Prot for LRRC17 Gene

  • Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).

Gene Wiki entry for LRRC17 Gene

Additional gene information for LRRC17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC17 Gene

Genomics for LRRC17 Gene

GeneHancer (GH) Regulatory Elements for LRRC17 Gene

Promoters and enhancers for LRRC17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I102912 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.4 +2.4 2411 6 ELF3 CTCF PKNOX1 JUN RAD21 ZNF316 ZNF366 PATZ1 ZNF547 FOSL2 LRRC17 RNU6-1136P FBXL13 DPY19L2P2 ARMC10 RASA4 RPL23AP95 NFE4 FAM185A
GH07I102926 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 550.4 +14.0 14038 1.9 MEIS2 TAL1 CBFA2T3 TCF12 ZNF316 JUND CBFA2T2 RCOR1 EMSY MAFK LRRC17 ARMC10 LRWD1 NFE4 FBXL13
GH07I102870 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -38.9 -38904 6.3 PKNOX1 FOXA2 SIN3A IRF4 ETS1 ATF7 FOS RUNX3 JUNB PPARG LRRC17 CRYZP1 FAM185A ENSG00000213385 POLR2J3 UPK3BL1 ARMC10 ORAI2 LRWD1 RN7SKP198
GH07I102987 Enhancer 1.5 Ensembl ENCODE dbSUPER 11 +78.5 78468 6.9 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF766 CBX5 PRKRIP1 ENSG00000213385 CRYZP1 ENSG00000239486 DNAJC2 NAPEPLD PMPCB ALKBH4 DPY19L2P2 LRRC17
GH07I102889 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.5 -21.3 -21317 3.6 HDAC1 MEIS2 ATF1 PKNOX1 JUN CEBPG ZBTB40 FOSL1 GATA2 POLR2A LRRC17 LRWD1 ORAI2 ARMC10 RN7SKP198 FAM185A FBXL13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC17 gene promoter:

Genomic Locations for LRRC17 Gene

Genomic Locations for LRRC17 Gene
32,215 bases
Plus strand

Genomic View for LRRC17 Gene

Genes around LRRC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC17 Gene

Proteins for LRRC17 Gene

  • Protein details for LRRC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 17
    Protein Accession:
    Secondary Accessions:
    • Q13288
    • Q6UWA7
    • Q75MG5

    Protein attributes for LRRC17 Gene

    441 amino acids
    Molecular mass:
    51800 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC17 Gene


neXtProt entry for LRRC17 Gene

Post-translational modifications for LRRC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC17 Gene

No data available for DME Specific Peptides for LRRC17 Gene

Domains & Families for LRRC17 Gene

Gene Families for LRRC17 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for LRRC17 Gene

Suggested Antigen Peptide Sequences for LRRC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC17: view

No data available for UniProtKB/Swiss-Prot for LRRC17 Gene

Function for LRRC17 Gene

Molecular function for LRRC17 Gene

UniProtKB/Swiss-Prot Function:
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).

Phenotypes From GWAS Catalog for LRRC17 Gene

genes like me logo Genes that share phenotypes with LRRC17: view

Animal Model Products

miRNA for LRRC17 Gene

miRTarBase miRNAs that target LRRC17

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC17 Gene

Localization for LRRC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC17 Gene

Secreted, extracellular space.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC17 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS --
genes like me logo Genes that share ontologies with LRRC17: view

Pathways & Interactions for LRRC17 Gene

SuperPathways for LRRC17 Gene

No Data Available

Interacting Proteins for LRRC17 Gene

Gene Ontology (GO) - Biological Process for LRRC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 NOT osteoblast differentiation ISS --
GO:0033687 NOT osteoblast proliferation ISS --
GO:0045671 negative regulation of osteoclast differentiation ISS --
GO:0048539 bone marrow development ISS --
genes like me logo Genes that share ontologies with LRRC17: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC17 Gene

Drugs & Compounds for LRRC17 Gene

No Compound Related Data Available

Transcripts for LRRC17 Gene

Unigene Clusters for LRRC17 Gene

Leucine rich repeat containing 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC17 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP2: -

Relevant External Links for LRRC17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC17 Gene

This gene is overexpressed in Ovary (x11.0), Artery - Coronary (x5.5), and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for LRRC17 Gene

This gene is overexpressed in Ovary (22.7), Monocytes (21.0), Tlymphocyte (10.8), and Neutrophil (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC17 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC17 Gene:


SOURCE GeneReport for Unigene cluster for LRRC17 Gene:


mRNA Expression by UniProt/SwissProt for LRRC17 Gene:

Tissue specificity: Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells.

Evidence on tissue expression from TISSUES for LRRC17 Gene

  • Pancreas(4.1)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with LRRC17: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC17 Gene

Orthologs for LRRC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC17 34 33
  • 99.55 (n)
(Bos Taurus)
Mammalia LRRC17 34 33
  • 90.02 (n)
(Canis familiaris)
Mammalia LRRC17 33 34
  • 85.51 (n)
(Monodelphis domestica)
Mammalia LRRC17 34
  • 85 (a)
(Mus musculus)
Mammalia Lrrc17 16 34 33
  • 84.13 (n)
(Rattus norvegicus)
Mammalia Lrrc17 33
  • 82.31 (n)
(Ornithorhynchus anatinus)
Mammalia LRRC17 34
  • 78 (a)
(Gallus gallus)
Aves LRRC17 33
  • 73.49 (n)
P37NB 34
  • 73 (a)
(Anolis carolinensis)
Reptilia LRRC17 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc17 33
  • 66.35 (n)
(Danio rerio)
Actinopterygii lrrc17 33 34
  • 56.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta sli 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea slt-1 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
Species where no ortholog for LRRC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC17 Gene

Gene Tree for LRRC17 (if available)
Gene Tree for LRRC17 (if available)

Paralogs for LRRC17 Gene

Paralogs for LRRC17 Gene

genes like me logo Genes that share paralogs with LRRC17: view

Variants for LRRC17 Gene

Sequence variations from dbSNP and Humsavar for LRRC17 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000007686 -- 102,922,871(+) A/G intron_variant
rs1000178607 -- 102,929,267(+) C/A intron_variant
rs1000196679 -- 102,936,358(+) T/C intron_variant
rs1000360631 -- 102,915,900(+) A/G intron_variant
rs1000376502 -- 102,944,038(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC17 Gene

Variant ID Type Subtype PubMed ID
dgv6538n100 CNV gain 25217958
esv1748254 CNV insertion 17803354
esv2452928 CNV insertion 19546169
esv2752138 CNV loss 17911159
esv3447330 CNV duplication 20981092
esv3614364 CNV loss 21293372
esv3614365 CNV loss 21293372
nsv464667 CNV loss 19166990
nsv608058 CNV gain 21841781
nsv608060 CNV loss 21841781

Variation tolerance for LRRC17 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC17 Gene

Disorders for LRRC17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC17 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC17

genes like me logo Genes that share disorders with LRRC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC17 Gene

Publications for LRRC17 Gene

  1. A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein, p37NB, isolated from S-type neuroblastoma cell has a differential tissue distribution. (PMID: 8982252) Kim D … Yang SY (Biochimica et biophysica acta 1996) 2 3 4 22 58
  2. Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. (PMID: 19336404) Kim T … Choi Y (The Journal of biological chemistry 2009) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for LRRC17 Gene

Sources for LRRC17 Gene

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