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Aliases for LRRC14B Gene

Aliases for LRRC14B Gene

  • Leucine Rich Repeat Containing 14B 2 3 5

External Ids for LRRC14B Gene

Previous GeneCards Identifiers for LRRC14B Gene

  • GC05P000246

Summaries for LRRC14B Gene

Entrez Gene Summary for LRRC14B Gene

  • The protein encoded by this gene is a leucine-rich repeat containing protein that is a member of the PRAME family. [provided by RefSeq, Apr 2017]

GeneCards Summary for LRRC14B Gene

LRRC14B (Leucine Rich Repeat Containing 14B) is a Protein Coding gene. An important paralog of this gene is LRRC14.

Additional gene information for LRRC14B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC14B Gene

Genomics for LRRC14B Gene

GeneHancer (GH) Regulatory Elements for LRRC14B Gene

Promoters and enhancers for LRRC14B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I000187 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.9 -1.2 -1198 5.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 GLIS2 ZNF143 KLF7 LRRC14B LOC100421419 SLC9A3-AS1 HRAT5 SDHA CCDC127 PLEKHG4B BRD9 EXOC3 PDCD6
GH05I000166 Enhancer 1 Ensembl ENCODE dbSUPER 0.3 -23.1 -23101 3.5 ZBTB10 L3MBTL2 MAX MNT NFIC EGR1 FOS EGR2 CCDC127 SDHA PLEKHG4B HRAT5 PIR34013 LRRC14B
GH05I000170 Enhancer 0.4 ENCODE dbSUPER 0.3 -21.1 -21148 0 CCDC127 PIR34013 LRRC14B PLEKHG4B
GH05I000175 Enhancer 0.2 FANTOM5 0.4 -16.1 -16114 0 PIR34013 LRRC14B PLEKHG4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC14B on UCSC Golden Path with GeneCards custom track

Genomic Locations for LRRC14B Gene

Genomic Locations for LRRC14B Gene
chr5:191,511-195,353
(GRCh38/hg38)
Size:
3,843 bases
Orientation:
Plus strand
chr5:191,626-195,468
(GRCh37/hg19)

Genomic View for LRRC14B Gene

Genes around LRRC14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC14B Gene

Proteins for LRRC14B Gene

  • Protein details for LRRC14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHZ5-LR14B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 14B
    Protein Accession:
    A6NHZ5

    Protein attributes for LRRC14B Gene

    Size:
    514 amino acids
    Molecular mass:
    56758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC14B Gene

Post-translational modifications for LRRC14B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC14B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC14B Gene

Domains & Families for LRRC14B Gene

Gene Families for LRRC14B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC14B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC14B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHZ5

UniProtKB/Swiss-Prot:

LR14B_HUMAN :
  • Belongs to the PRAME family. LRRC14 subfamily.
Family:
  • Belongs to the PRAME family. LRRC14 subfamily.
genes like me logo Genes that share domains with LRRC14B: view

Function for LRRC14B Gene

Phenotypes for LRRC14B Gene

GenomeRNAi human phenotypes for LRRC14B:
genes like me logo Genes that share phenotypes with LRRC14B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC14B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC14B Gene

Localization for LRRC14B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC14B gene
Compartment Confidence
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC14B Gene

Pathways & Interactions for LRRC14B Gene

SuperPathways for LRRC14B Gene

No Data Available

Interacting Proteins for LRRC14B Gene

Gene Ontology (GO) - Biological Process for LRRC14B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC14B Gene

Drugs & Compounds for LRRC14B Gene

No Compound Related Data Available

Transcripts for LRRC14B Gene

mRNA/cDNA for LRRC14B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC14B Gene

Leucine rich repeat containing 14B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC14B Gene

No ASD Table

Relevant External Links for LRRC14B Gene

GeneLoc Exon Structure for
LRRC14B
ECgene alternative splicing isoforms for
LRRC14B

Expression for LRRC14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC14B Gene

mRNA differential expression in normal tissues according to GTEx for LRRC14B Gene

This gene is overexpressed in Heart - Left Ventricle (x20.6), Muscle - Skeletal (x18.5), and Heart - Atrial Appendage (x9.5).

Protein differential expression in normal tissues from HIPED for LRRC14B Gene

This gene is overexpressed in CD8 Tcells (28.9), Frontal cortex (10.9), Ovary (10.8), and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC14B Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC14B Gene:

LRRC14B

SOURCE GeneReport for Unigene cluster for LRRC14B Gene:

Hs.683662
genes like me logo Genes that share expression patterns with LRRC14B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC14B Gene

Orthologs for LRRC14B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC14B 34 33
  • 99.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC14B 33 34
  • 82.61 (n)
cow
(Bos Taurus)
Mammalia LRRC14B 34 33
  • 82.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc14b 16 34 33
  • 78.95 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc14b 33
  • 77.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC14B 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC14B 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC14B 34 33
  • 57.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC14B 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488798 33
  • 52.86 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc14b 33 34
  • 54.15 (n)
Species where no ortholog for LRRC14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC14B Gene

ENSEMBL:
Gene Tree for LRRC14B (if available)
TreeFam:
Gene Tree for LRRC14B (if available)

Paralogs for LRRC14B Gene

(1) SIMAP similar genes for LRRC14B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC14B: view

Variants for LRRC14B Gene

Sequence variations from dbSNP and Humsavar for LRRC14B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs199834750 not-provided, not provided 194,997(+) G/A coding_sequence_variant, missense_variant
rs1000609836 -- 189,629(+) A/G upstream_transcript_variant
rs1000697452 -- 194,293(+) C/T intron_variant
rs1001058209 -- 190,887(+) A/ upstream_transcript_variant
rs1001210145 -- 190,892(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC14B Gene

Variant ID Type Subtype PubMed ID
esv1003523 CNV insertion 20482838
esv1064788 CNV insertion 17803354
esv2752083 CNV gain 17911159
esv2759315 CNV loss 17122850
esv2763907 CNV gain+loss 21179565
esv3569895 CNV loss 25503493
esv3603735 CNV loss 21293372
esv3894107 CNV gain 25118596
nsv1018481 CNV gain 25217958
nsv1018482 CNV loss 25217958
nsv1028658 CNV gain 25217958
nsv1028927 CNV loss 25217958
nsv1030767 CNV gain 25217958
nsv428458 CNV loss 18775914
nsv461886 CNV loss 19166990
nsv470983 CNV loss 18288195
nsv515806 CNV loss 19592680
nsv518607 CNV gain 19592680
nsv523382 CNV loss 19592680
nsv596610 CNV loss 21841781
nsv596611 CNV loss 21841781

Variation tolerance for LRRC14B Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC14B Gene

Disorders for LRRC14B Gene

Additional Disease Information for LRRC14B

No disorders were found for LRRC14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC14B Gene

Publications for LRRC14B Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 58

Products for LRRC14B Gene

Sources for LRRC14B Gene

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