Aliases for LRRC10B Gene

Aliases for LRRC10B Gene

  • Leucine Rich Repeat Containing 10B 2 3 5
  • Leucine-Rich Repeat-Containing Protein 10B 3 4
  • LRRC10-Like Protein ENSP00000367315 3
  • LRRC10B 5

External Ids for LRRC10B Gene

Previous GeneCards Identifiers for LRRC10B Gene

  • GC11P061035
  • GC11P061277
  • GC11P057603

Summaries for LRRC10B Gene

GeneCards Summary for LRRC10B Gene

LRRC10B (Leucine Rich Repeat Containing 10B) is a Protein Coding gene. An important paralog of this gene is LRRC10.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC10B Gene

Genomics for LRRC10B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J061507 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 250.7 +0.2 173 2.2 EZH2 ZNF600 ZNF10 ZIC2 MXD4 ZNF341 ZEB1 CTCF SIN3A KLF9 HSALNG0084538 LRRC10B MIR4488 piR-43106-035 SYT7 ENSG00000279878 HSALNG0084539
GH11J061539 Enhancer 1.5 VISTA Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 +33.9 33852 9.6 IKZF1 CEBPA NFIC CHD4 YY1 REST CEBPB CTCF ZNF217 HCFC1 ENSG00000256443 LRRC10B SYT7 DDB1 TKFC ZP1 HSALNG0084540 lnc-CPSF7-4 lnc-CPSF7-5
GH11J061541 Enhancer 0.4 Ensembl dbSUPER 12.4 +28.6 28552 0.2 CHD2 HSALNG0084540 LRRC10B SYT7 DDB1 TKFC HSALNG0084539 ENSG00000279878
GH11J061538 Enhancer 0.4 Ensembl dbSUPER 12.1 +27.7 27652 0.4 YY1 LRRC10B SYT7 HSALNG0084540 ENSG00000279878 HSALNG0084539
GH11J061498 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.1 -8.9 -8935 2.4 SMAD5 TBP NR2C1 TAF9B ELF1 GABPB1 TAL1 SUPT5H EHMT2 ZC3H8 LOC105369329 TMEM216 DDB1 TKFC LRRC10B ENSG00000255931 piR-43106-035 PPP1R32
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC10B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC10B

Genomic Locations for LRRC10B Gene

Latest Assembly
chr11:61,508,749-61,511,018
(GRCh38/hg38)
Size:
2,270 bases
Orientation:
Plus strand

Previous Assembly
chr11:61,276,221-61,278,490
(GRCh37/hg19 by Entrez Gene)
Size:
2,270 bases
Orientation:
Plus strand

chr11:61,276,272-61,278,482
(GRCh37/hg19 by Ensembl)
Size:
2,211 bases
Orientation:
Plus strand

Genomic View for LRRC10B Gene

Genes around LRRC10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC10B Gene

Proteins for LRRC10B Gene

  • Protein details for LRRC10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIK2-LR10B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 10B
    Protein Accession:
    A6NIK2

    Protein attributes for LRRC10B Gene

    Size:
    292 amino acids
    Molecular mass:
    32714 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC10B Gene

Post-translational modifications for LRRC10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC10B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC10B Gene

Domains & Families for LRRC10B Gene

Gene Families for LRRC10B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC10B Gene

Suggested Antigen Peptide Sequences for LRRC10B Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 10B (LR10B_HUMAN)
genes like me logo Genes that share domains with LRRC10B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC10B Gene

Function for LRRC10B Gene

Phenotypes From GWAS Catalog for LRRC10B Gene

Gene Ontology (GO) - Molecular Function for LRRC10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC10B: view

miRNA for LRRC10B Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC10B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC10B Gene

Localization for LRRC10B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC10B gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC10B Gene

Pathways & Interactions for LRRC10B Gene

PathCards logo

SuperPathways for LRRC10B Gene

No Data Available

Interacting Proteins for LRRC10B Gene

Gene Ontology (GO) - Biological Process for LRRC10B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC10B Gene

Drugs & Compounds for LRRC10B Gene

No Compound Related Data Available

Transcripts for LRRC10B Gene

mRNA/cDNA for LRRC10B Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC10B

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC10B Gene

No ASD Table

Relevant External Links for LRRC10B Gene

GeneLoc Exon Structure for
LRRC10B

Expression for LRRC10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC10B Gene

mRNA differential expression in normal tissues according to GTEx for LRRC10B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.5), Brain - Caudate (basal ganglia) (x7.4), Brain - Nucleus accumbens (basal ganglia) (x6.8), and Pituitary (x6.1).

Protein differential expression in normal tissues from HIPED for LRRC10B Gene

This gene is overexpressed in Liver (25.1), Heart (17.9), and Esophagus (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC10B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC10B

SOURCE GeneReport for Unigene cluster for LRRC10B Gene:

Hs.441122
genes like me logo Genes that share expression patterns with LRRC10B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC10B Gene

Orthologs for LRRC10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC10B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LRRC10B 29 30
  • 92.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC10B 29 30
  • 92.81 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrrc10b 29 16 30
  • 90.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc10b 29
  • 90.18 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia LRRC10B 30
  • 82 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LRRC10B 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRC10B 29 30
  • 72.92 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC10B 30
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc10b 29
  • 56.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC798319 29
  • 61.66 (n)
LRRC10B 30
  • 53 (a)
OneToOne
Species where no ortholog for LRRC10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRRC10B Gene

ENSEMBL:
Gene Tree for LRRC10B (if available)
TreeFam:
Gene Tree for LRRC10B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC10B: view image
Alliance of Genome Resources:
Additional Orthologs for LRRC10B

Paralogs for LRRC10B Gene

(1) SIMAP similar genes for LRRC10B Gene using alignment to 1 proteins:

  • LR10B_HUMAN
genes like me logo Genes that share paralogs with LRRC10B: view

Variants for LRRC10B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRRC10B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRRC10B Gene

Variant ID Type Subtype PubMed ID
dgv1962n54 CNV loss 21841781
nsv1070462 CNV deletion 25765185
nsv468582 CNV loss 19166990
nsv555167 CNV loss 21841781
nsv555168 CNV loss 21841781
nsv825938 CNV gain 20364138
nsv832178 CNV gain+loss 17160897

Variation tolerance for LRRC10B Gene

Gene Damage Index Score: 0.80; 16.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC10B Gene

Human Gene Mutation Database (HGMD)
LRRC10B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC10B
Leiden Open Variation Database (LOVD)
LRRC10B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC10B Gene

Disorders for LRRC10B Gene

Additional Disease Information for LRRC10B

No disorders were found for LRRC10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC10B Gene

Publications for LRRC10B Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  2. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. (PMID: 31741433) Zeng H … Cong F (eLife 2019) 3
  3. Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma. (PMID: 27460542) Chen J … Wang Y (Oncology reports 2016) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for LRRC10B Gene

Sources for LRRC10B Gene