Aliases for LRRC10 Gene

Aliases for LRRC10 Gene

  • Leucine Rich Repeat Containing 10 2 3 5
  • Heart-Restricted Leucine-Rich Repeat Protein 2 3
  • Leucine-Rich Repeat-Containing Protein 10 3 4
  • LRRC10A 2 3
  • HRLRRP 2 3
  • LRRC10 5

External Ids for LRRC10 Gene

Previous GeneCards Identifiers for LRRC10 Gene

  • GC12U900436
  • GC12M068288
  • GC12M070002
  • GC12M067051

Summaries for LRRC10 Gene

GeneCards Summary for LRRC10 Gene

LRRC10 (Leucine Rich Repeat Containing 10) is a Protein Coding gene. Diseases associated with LRRC10 include Dilated Cardiomyopathy and Anomalous Left Coronary Artery From The Pulmonary Artery. Gene Ontology (GO) annotations related to this gene include actin binding and alpha-actinin binding. An important paralog of this gene is LRRC10B.

UniProtKB/Swiss-Prot Summary for LRRC10 Gene

  • May play important roles in cardiac development and/or cardiac function.

Additional gene information for LRRC10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRRC10 Gene

Genomics for LRRC10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRRC10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J069584 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +25.4 25406 3.4 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 RFX1 NFKBIZ CTCF POLR2A CCT2 HSALNG0092270 MIR3913-1 MIR3913-2 CPSF6 CNOT2 NUP107 FRS2 LRRC10 LYZ
GH12J069655 Enhancer 1.1 Ensembl ENCODE 12 -47.1 -47094 6 CREB1 ATF7 RFX1 LEF1 IKZF1 JUND MTA2 NR2C1 ZNF24 BRD9 piR-48759-061 BEST3 RAB3IP LRRC10 ENSG00000247131 ENSG00000279551 lnc-LRRC10-2 LOC105369823
GH12J069664 Enhancer 0.5 Ensembl 11 -54.7 -54693 0.8 CTCF SP1 ZNF444 FOXA2 RAD21 HNF4A REST TRIM22 CREB1 RF00017-1181 BEST3 LRRC10 RAB3IP lnc-LRRC10-3 LOC105369823
GH12J069581 Enhancer 0.5 Ensembl 10.2 +30.0 30006 0.6 SMARCA5 CTBP1 RBM22 SIN3A GATA3 DPF2 SMARCE1 ZNF362 piR-55985-033 LYZ LRRC10 FRS2 CCT2 MIR3913-2
GH12J069666 Enhancer 0.5 Ensembl 11 -55.9 -55894 0.8 SP1 HDAC2 HNF4A CBFA2T2 CBFA2T3 RF00017-1181 LRRC10 BEST3 lnc-LRRC10-3 LOC105369823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRRC10

Top Transcription factor binding sites by QIAGEN in the LRRC10 gene promoter:
  • AML1a
  • AREB6
  • CREB
  • deltaCREB
  • NF-kappaB1
  • Olf-1
  • SREBP-1a
  • Zic1

Genomic Locations for LRRC10 Gene

Genomic Locations for LRRC10 Gene
chr12:69,608,564-69,610,907
(GRCh38/hg38)
Size:
2,344 bases
Orientation:
Minus strand
chr12:70,002,344-70,004,942
(GRCh37/hg19)
Size:
2,599 bases
Orientation:
Minus strand

Genomic View for LRRC10 Gene

Genes around LRRC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC10 Gene

Proteins for LRRC10 Gene

  • Protein details for LRRC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKY1-LRC10_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 10
    Protein Accession:
    Q5BKY1
    Secondary Accessions:
    • Q6ZVY4

    Protein attributes for LRRC10 Gene

    Size:
    277 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC10 Gene

Post-translational modifications for LRRC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC10 Gene

Domains & Families for LRRC10 Gene

Gene Families for LRRC10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC10 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC10 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 10 (LRC10_HUMAN)
  • LRRC10 protein (Q3B873_HUMAN)
  • LRRC10 protein (Q3KP57_HUMAN)
genes like me logo Genes that share domains with LRRC10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRRC10 Gene

Function for LRRC10 Gene

Molecular function for LRRC10 Gene

UniProtKB/Swiss-Prot Function:
May play important roles in cardiac development and/or cardiac function.

Phenotypes From GWAS Catalog for LRRC10 Gene

Gene Ontology (GO) - Molecular Function for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IBA 21873635
GO:0005515 protein binding IEA --
GO:0051393 alpha-actinin binding IEA --
genes like me logo Genes that share ontologies with LRRC10: view
genes like me logo Genes that share phenotypes with LRRC10: view

Animal Models for LRRC10 Gene

MGI Knock Outs for LRRC10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC10 Gene

Localization for LRRC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC10 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005856 cytoskeleton IEA,IBA 21873635
GO:0030016 myofibril IEA --
GO:0030017 sarcomere IEA,IBA 21873635
genes like me logo Genes that share ontologies with LRRC10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRRC10 Gene

Pathways & Interactions for LRRC10 Gene

PathCards logo

SuperPathways for LRRC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055013 cardiac muscle cell development IBA 21873635
genes like me logo Genes that share ontologies with LRRC10: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC10 Gene

Drugs & Compounds for LRRC10 Gene

No Compound Related Data Available

Transcripts for LRRC10 Gene

mRNA/cDNA for LRRC10 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRRC10

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC10 Gene

No ASD Table

Relevant External Links for LRRC10 Gene

GeneLoc Exon Structure for
LRRC10

Expression for LRRC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Heart (Cardiovascular System)

mRNA differential expression in normal tissues according to GTEx for LRRC10 Gene

This gene is overexpressed in Heart - Left Ventricle (x35.6) and Heart - Atrial Appendage (x15.6).

Protein differential expression in normal tissues from HIPED for LRRC10 Gene

This gene is overexpressed in Heart (39.0) and Fetal heart (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC10 Gene



Protein tissue co-expression partners for LRRC10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRRC10

SOURCE GeneReport for Unigene cluster for LRRC10 Gene:

Hs.448708

Evidence on tissue expression from TISSUES for LRRC10 Gene

  • Heart(4.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with LRRC10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC10 Gene

Orthologs for LRRC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRRC10 30 31
  • 99.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRRC10 30 31
  • 91.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrrc10 30 17 31
  • 85.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrrc10 30
  • 84.86 (n)
Dog
(Canis familiaris)
Mammalia LRRC10 30 31
  • 83.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia LRRC10 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRRC10 30 31
  • 76.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRRC10 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrrc10 30
  • 64.96 (n)
Zebrafish
(Danio rerio)
Actinopterygii lrrc10 30 31
  • 61.33 (n)
OneToOne
Species where no ortholog for LRRC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRRC10 Gene

ENSEMBL:
Gene Tree for LRRC10 (if available)
TreeFam:
Gene Tree for LRRC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC10: view image

Paralogs for LRRC10 Gene

(4) SIMAP similar genes for LRRC10 Gene using alignment to 3 proteins:

  • LRC10_HUMAN
  • Q3B873_HUMAN
  • Q3KP57_HUMAN
genes like me logo Genes that share paralogs with LRRC10: view

Variants for LRRC10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRRC10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
642165 Uncertain Significance: Dilated Cardiomyopathy, Dominant 69,610,231(-) C/T MISSENSE_VARIANT
645534 Uncertain Significance: Dilated Cardiomyopathy, Dominant 69,610,763(-) G/A MISSENSE_VARIANT
647246 Uncertain Significance: Dilated Cardiomyopathy, Dominant 69,610,669(-) A/G MISSENSE_VARIANT
655328 Uncertain Significance: Dilated Cardiomyopathy, Dominant 69,610,243(-) C/G MISSENSE_VARIANT
659204 Uncertain Significance: Dilated Cardiomyopathy, Dominant 69,610,275(-) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LRRC10 Gene

Variation tolerance for LRRC10 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC10 Gene

Human Gene Mutation Database (HGMD)
LRRC10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC10 Gene

Disorders for LRRC10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
anomalous left coronary artery from the pulmonary artery
  • alcapa
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC10

genes like me logo Genes that share disorders with LRRC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC10 Gene

Publications for LRRC10 Gene

  1. LRRC10 is required to maintain cardiac function in response to pressure overload. (PMID: 26608339) Brody MJ … Lee Y (American journal of physiology. Heart and circulatory physiology 2016) 2 3
  2. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. (PMID: 14751244) Nakane T … Chiba S (Biochemical and biophysical research communications 2004) 2 3

Products for LRRC10 Gene

Sources for LRRC10 Gene