Aliases for LRPAP1 Gene
- LDL Receptor Related Protein Associated Protein 1 2 3 5
- Low Density Lipoprotein-Related Protein-Associated Protein 1 (Alpha-2-Macroglobulin Receptor-Associated Protein 1) 2 3
- Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 2 3
- Alpha-2-MRAP 3 4
- A2MRAP 3 4
- RAP 3 4
- Low Density Lipoprotein Receptor-Related Protein-Associated Protein 1 4
External Ids for LRPAP1 Gene
Previous HGNC Symbols for LRPAP1 Gene
Previous GeneCards Identifiers for LRPAP1 Gene
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
GeneCards Summary for LRPAP1 Gene
LRPAP1 (LDL Receptor Related Protein Associated Protein 1) is a Protein Coding gene. Diseases associated with LRPAP1 include Myopia 23, Autosomal Recessive and Rare Isolated Myopia. Among its related pathways are Lissencephaly gene (LIS1) in neuronal migration and development and Signaling events mediated by the Hedgehog family. Gene Ontology (GO) annotations related to this gene include heparin binding and low-density lipoprotein particle receptor binding.
UniProtKB/Swiss-Prot for LRPAP1 Gene
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.