Aliases for LRP5L Gene

Aliases for LRP5L Gene

  • LDL Receptor Related Protein 5 Like 2 3 5
  • Low-Density Lipoprotein Receptor-Related Protein 5-Like Protein 3 4
  • Low Density Lipoprotein Receptor-Related Protein 5-Like 2 3
  • LRP-5-Like 3 4
  • DKFZp434O0213 2
  • LRP5L 5

External Ids for LRP5L Gene

Previous GeneCards Identifiers for LRP5L Gene

  • GC22M024072
  • GC22M024077
  • GC22M025747
  • GC22M008694

Summaries for LRP5L Gene

GeneCards Summary for LRP5L Gene

LRP5L (LDL Receptor Related Protein 5 Like) is a Protein Coding gene. Diseases associated with LRP5L include Periodontosis and Ichthyosis, Congenital, Autosomal Recessive 9. Gene Ontology (GO) annotations related to this gene include Wnt-protein binding and Wnt-activated receptor activity. An important paralog of this gene is LRP5.

Additional gene information for LRP5L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRP5L Gene

Genomics for LRP5L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRP5L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J025402 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 621.8 +0.8 800 5 HNRNPL GATAD2A PRDM10 SOX13 KDM1A ZNF692 RCOR2 BACH1 LARP7 ZIC2 LRP5L LRRC75B ENSG00000231466 ENSG00000272977 RF00017-3786 CRYBB2
GH22J025398 Enhancer 0.9 ENCODE dbSUPER 21.3 +6.5 6549 0.8 SP1 PRDM10 BACH1 LARP7 ZNF143 PATZ1 TCF12 IKZF2 TRIM22 EED LRP5L RF00017-3786 CRYBB2
GH22J025394 Enhancer 0.8 dbSUPER 21.3 +9.9 9932 1.9 HNRNPL GATAD2A TFE3 RCOR2 RXRB CEBPA FOXK2 SCRT2 SOX13 TCF7 LRP5L ENSG00000231466 RF00017-3786 CRYBB2
GH22J025418 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.1 -14.3 -14346 1.4 CREB1 GATAD2A PRDM10 ZNF629 LEF1 ZNF692 ZIC2 PATZ1 IKZF2 EZH2 lnc-GRK3-10 ENSG00000272977 ENSG00000272798 LRP5L GRK3 piR-60463
GH22J025400 Enhancer 1.1 ENCODE dbSUPER 9.2 +4.4 4359 1.3 HNRNPL GATAD2A PRDM10 SOX13 NFKBIZ ZNF692 RCOR2 LARP7 ZIC2 RXRB LRP5L ENSG00000231466 RF00017-3786 CRYBB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRP5L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRP5L

Top Transcription factor binding sites by QIAGEN in the LRP5L gene promoter:
  • AML1a
  • ATF6
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for LRP5L Gene

Genomic Locations for LRP5L Gene
53,993 bases
Minus strand
53,960 bases
Minus strand

Genomic View for LRP5L Gene

Genes around LRP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP5L Gene

Proteins for LRP5L Gene

  • Protein details for LRP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 5-like protein
    Protein Accession:
    Secondary Accessions:
    • B0QYF3
    • B0QYF4
    • B2RPI5

    Protein attributes for LRP5L Gene

    252 amino acids
    Molecular mass:
    28483 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRP5L Gene


neXtProt entry for LRP5L Gene

Post-translational modifications for LRP5L Gene

No Post-translational modifications

No data available for DME Specific Peptides for LRP5L Gene

Domains & Families for LRP5L Gene

Gene Families for LRP5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRP5L Gene

Suggested Antigen Peptide Sequences for LRP5L Gene

GenScript: Design optimal peptide antigens:
  • Low-density lipoprotein receptor-related protein 5-like protein (LRP5L_HUMAN)
genes like me logo Genes that share domains with LRP5L: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRP5L Gene

Function for LRP5L Gene

Phenotypes From GWAS Catalog for LRP5L Gene

Gene Ontology (GO) - Molecular Function for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015026 coreceptor activity IBA 21873635
GO:0017147 Wnt-protein binding IBA --
GO:0042813 Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with LRP5L: view
genes like me logo Genes that share phenotypes with LRP5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRP5L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRP5L Gene

Localization for LRP5L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP5L gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
extracellular 0
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0043235 receptor complex IBA --
genes like me logo Genes that share ontologies with LRP5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRP5L Gene

Pathways & Interactions for LRP5L Gene

PathCards logo

SuperPathways for LRP5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IBA 21873635
GO:0002076 osteoblast development IBA 21873635
GO:0009952 anterior/posterior pattern specification IBA 21873635
GO:0042632 cholesterol homeostasis IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with LRP5L: view

No data available for Pathways by source and SIGNOR curated interactions for LRP5L Gene

Drugs & Compounds for LRP5L Gene

No Compound Related Data Available

Transcripts for LRP5L Gene

mRNA/cDNA for LRP5L Gene

7 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRP5L

Alternative Splicing Database (ASD) splice patterns (SP) for LRP5L Gene

No ASD Table

Relevant External Links for LRP5L Gene

GeneLoc Exon Structure for

Expression for LRP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRP5L Gene

Protein differential expression in normal tissues from HIPED for LRP5L Gene

This gene is overexpressed in Breast (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRP5L Gene

Protein tissue co-expression partners for LRP5L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRP5L

SOURCE GeneReport for Unigene cluster for LRP5L Gene:


Evidence on tissue expression from TISSUES for LRP5L Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with LRP5L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP5L Gene

Orthologs for LRP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP5L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP5L 31
  • 94 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
-- 31
  • 7 (a)
-- 31
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 21 (a)
(Bos Taurus)
Mammalia LRP5 31
  • 12 (a)
(Canis familiaris)
Mammalia LRP5 31
  • 12 (a)
(Gallus gallus)
Aves LRP5 31
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 10 (a)
(Danio rerio)
Actinopterygii lrp5 31
  • 10 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta arr 31
  • 7 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
Species where no ortholog for LRP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRP5L Gene

Gene Tree for LRP5L (if available)
Gene Tree for LRP5L (if available)
Evolutionary constrained regions (ECRs) for LRP5L: view image

Paralogs for LRP5L Gene

Paralogs for LRP5L Gene

(12) SIMAP similar genes for LRP5L Gene using alignment to 2 proteins:

  • F5H316_HUMAN
genes like me logo Genes that share paralogs with LRP5L: view

Variants for LRP5L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRP5L Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs17616994 - p.Thr61Met

Additional dbSNP identifiers (rs#s) for LRP5L Gene

Structural Variations from Database of Genomic Variants (DGV) for LRP5L Gene

Variant ID Type Subtype PubMed ID
dgv100e203 CNV gain+loss 21179565
dgv1304e212 CNV gain 25503493
dgv1305e212 CNV loss 25503493
dgv1306e212 CNV loss 25503493
dgv1307e212 CNV gain 25503493
dgv175e55 CNV gain 17911159
dgv176e55 CNV loss 17911159
dgv177e55 CNV loss 17911159
dgv24e196 CNV duplication 17116639
dgv44e213 CNV gain 24956385
dgv44n64 CNV gain 17921354
dgv4545n100 CNV loss 25217958
dgv4547n100 CNV gain 25217958
dgv4548n100 CNV loss 25217958
dgv4549n100 CNV gain+loss 25217958
dgv4550n100 CNV gain 25217958
dgv4552n100 CNV loss 25217958
dgv4554n100 CNV loss 25217958
dgv4555n100 CNV gain 25217958
dgv4556n100 CNV gain+loss 25217958
dgv4557n100 CNV gain 25217958
dgv45n64 CNV loss 17921354
dgv575n27 CNV loss 19166990
dgv576n27 CNV gain 19166990
dgv577n27 CNV gain 19166990
dgv578n27 CNV loss 19166990
dgv68n17 CNV loss 16327808
dgv731e201 CNV deletion 23290073
dgv756n67 CNV gain 20364138
dgv8071n54 CNV gain 21841781
dgv8072n54 CNV gain 21841781
dgv8073n54 CNV gain+loss 21841781
dgv8074n54 CNV gain 21841781
dgv8075n54 CNV loss 21841781
dgv8076n54 CNV loss 21841781
dgv8077n54 CNV loss 21841781
dgv8078n54 CNV gain 21841781
dgv8079n54 CNV loss 21841781
dgv828e199 CNV deletion 23128226
dgv830e214 CNV gain 21293372
dgv831e214 CNV gain 21293372
esv23681 CNV gain+loss 19812545
esv2421729 OTHER complex 20811451
esv2496250 CNV gain 19546169
esv2751952 CNV gain 17911159
esv2758829 CNV gain+loss 17122850
esv32873 CNV gain+loss 17666407
esv3647457 CNV loss 21293372
esv3647461 CNV loss 21293372
esv3893465 CNV gain+loss 25118596
esv3893466 CNV gain 25118596
esv3893467 CNV gain 25118596
nsv1055442 CNV gain 25217958
nsv1056779 CNV loss 25217958
nsv1062814 CNV gain 25217958
nsv1065248 CNV loss 25217958
nsv1067300 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv1126013 CNV deletion 24896259
nsv1160745 CNV deletion 26073780
nsv1160747 OTHER complex 26073780
nsv428388 CNV loss 18775914
nsv433458 CNV gain 18776910
nsv436347 CNV deletion 17901297
nsv436354 CNV deletion 17901297
nsv436865 CNV insertion 17901297
nsv437190 CNV loss 16327808
nsv437193 CNV loss 16327808
nsv438341 CNV loss 16468122
nsv442794 CNV gain+loss 18776908
nsv459716 CNV gain 19166990
nsv459853 CNV loss 19166990
nsv459855 CNV gain 19166990
nsv459856 CNV loss 19166990
nsv469622 CNV gain+loss 16826518
nsv469659 CNV gain+loss 16826518
nsv471189 CNV gain 18288195
nsv471190 CNV loss 18288195
nsv514967 CNV gain+loss 21397061
nsv517205 CNV gain+loss 19592680
nsv588756 CNV gain+loss 21841781
nsv588827 CNV gain 21841781
nsv588831 CNV loss 21841781
nsv588839 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817983 CNV gain+loss 17921354
nsv820110 CNV gain 19587683
nsv821696 CNV gain 15273396
nsv829134 CNV gain 20364138
nsv834163 CNV gain+loss 17160897
nsv834164 CNV gain+loss 17160897
nsv962871 CNV duplication 23825009
nsv9890 CNV gain+loss 18304495

Variation tolerance for LRP5L Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP5L Gene

Disorders for LRP5L Gene

MalaCards: The human disease database

(3) MalaCards diseases for LRP5L Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • periodontitis, juvenile
ichthyosis, congenital, autosomal recessive 9
  • arci9
epilepsy, myoclonic juvenile
  • ejm
- elite association - COSMIC cancer census association via MalaCards
Search LRP5L in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with LRP5L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRP5L Gene

Publications for LRP5L Gene

  1. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for LRP5L Gene

Sources for LRP5L Gene