Aliases for LRP1B Gene
External Ids for LRP1B Gene
Previous GeneCards Identifiers for LRP1B Gene
This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
LRP1B is a putative tumor suppressor and a member of the low-density lipoprotein (LDL) receptor family. The LDL receptor family have roles related to clearance of extracellular ligand and are proposed to be involved in extracellular signal transduction. silencing and down-expression of LRP1B as been observed in renal cell carcinoma and thyroid cancer. Further Deletion of LRP1B has been associated with chemotherapy resistance in high-grade serous cancers.
GeneCards Summary for LRP1B Gene
LRP1B (LDL Receptor Related Protein 1B) is a Protein Coding gene. Diseases associated with LRP1B include Epilepsy, Idiopathic Generalized 9 and Meier-Gorlin Syndrome 2. Gene Ontology (GO) annotations related to this gene include calcium ion binding and low-density lipoprotein particle receptor activity. An important paralog of this gene is LRP1.
UniProtKB/Swiss-Prot Summary for LRP1B Gene
Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.