This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016] See more...

Aliases for LRP1B Gene

Aliases for LRP1B Gene

  • LDL Receptor Related Protein 1B 2 3 5
  • LRP-DIT 2 3 4
  • LRPDIT 2 3 4
  • Low Density Lipoprotein Receptor-Related Protein 1B 2 3
  • Low-Density Lipoprotein Receptor-Related Protein 1B 3 4
  • LRP-Deleted In Tumors 2 3
  • LRP-1B 3 4
  • Low Density Lipoprotein Receptor Related Protein-Deleted In Tumor 3
  • Low-Density Lipoprotein Receptor-Related Protein-Deleted In Tumor 4
  • Low Density Lipoprotein-Related Protein 1B (Deleted In Tumors) 3
  • EC 51
  • EC 51
  • LRP1B 5

External Ids for LRP1B Gene

Previous GeneCards Identifiers for LRP1B Gene

  • GC02M138677
  • GC02M139296
  • GC02M141011
  • GC02M141199
  • GC02M140822
  • GC02M140705
  • GC02M132979
  • GC02M141012
  • GC02M141017
  • GC02M141020
  • GC02M141023

Summaries for LRP1B Gene

Entrez Gene Summary for LRP1B Gene

  • This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]

CIViC Summary for LRP1B Gene

  • LRP1B is a putative tumor suppressor and a member of the low-density lipoprotein (LDL) receptor family. The LDL receptor family have roles related to clearance of extracellular ligand and are proposed to be involved in extracellular signal transduction. silencing and down-expression of LRP1B as been observed in renal cell carcinoma and thyroid cancer. Further Deletion of LRP1B has been associated with chemotherapy resistance in high-grade serous cancers.

GeneCards Summary for LRP1B Gene

LRP1B (LDL Receptor Related Protein 1B) is a Protein Coding gene. Diseases associated with LRP1B include Epilepsy, Idiopathic Generalized 9 and Meier-Gorlin Syndrome 2. Gene Ontology (GO) annotations related to this gene include calcium ion binding and low-density lipoprotein particle receptor activity. An important paralog of this gene is LRP1.

UniProtKB/Swiss-Prot Summary for LRP1B Gene

  • Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Gene Wiki entry for LRP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRP1B Gene

Genomics for LRP1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRP1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J142130 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 610.7 +1.7 1713 2.9 CEBPG PRDM10 SOX13 PRDM1 ZIC2 ZSCAN4 ZNF501 EZH2 ZNF600 ZNF341 LRP1B ENSG00000244125 piR-43106-124
GH02J142112 Enhancer 0.8 Ensembl ENCODE 10.2 +19.3 19298 0.9 CTCF ZBTB44 CEBPB ZFHX2 TCF7L2 ZNF366 ZNF843 PRDM6 ZNF660 FOS LRP1B piR-43106-124
GH02J142184 Enhancer 0.8 Ensembl ENCODE 8.3 -53.6 -53568 3 PRDM10 ZIC2 GABPA SP1 JUND ZXDB ZBTB48 FOS CTCF FOSL2 LRP1B RF00994-520 ENSG00000244125 KYNU
GH02J142037 Enhancer 0.5 Ensembl 12.2 +94.8 94762 1.8 PRDM10 CTCF RAD21 JUND POLR2A EBF1 SMARCA4 EZH2 LRP1B piR-43106-124
GH02J142040 Enhancer 0.6 Ensembl ENCODE 6.2 +91.0 90962 2.6 ZBTB20 MAX PRDM6 LRP1B piR-43106-124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRP1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRP1B

Top Transcription factor binding sites by QIAGEN in the LRP1B gene promoter:
  • c-Myc
  • Evi-1
  • IRF-7A
  • ISGF-3
  • Max1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LRP1B Gene

Genomic Locations for LRP1B Gene
1,901,041 bases
Minus strand
1,900,279 bases
Minus strand

Genomic View for LRP1B Gene

Genes around LRP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP1B Gene

Proteins for LRP1B Gene

  • Protein details for LRP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 1B
    Protein Accession:
    Secondary Accessions:
    • Q8WY29
    • Q8WY30
    • Q8WY31

    Protein attributes for LRP1B Gene

    4599 amino acids
    Molecular mass:
    515498 Da
    Quaternary structure:
    • Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.
    • The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.

neXtProt entry for LRP1B Gene

Selected DME Specific Peptides for LRP1B Gene


Post-translational modifications for LRP1B Gene

  • Glycosylation at Asn134, Asn190, Asn220, Asn313, Asn360, Asn443, Asn725, Asn758, Asn829, Asn883, Asn919, Asn1041, Asn1089, Asn1145, Asn1209, Asn1298, Asn1502, Asn1549, Asn1636, Asn1754, Asn1816, Asn1921, Asn1983, Asn2105, Asn2458, Asn2488, Asn2507, Asn2549, Asn2626, Asn2647, Asn2802, Asn2892, Asn3034, Asn3066, Asn3076, Asn3164, Asn3310, Asn3316, Asn3682, Asn3877, Asn3894, Asn3906, Asn4017, Asn4204, Asn4381, and Asn4420
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LRP1B_HUMAN (1466)

Other Protein References for LRP1B Gene

Domains & Families for LRP1B Gene

Gene Families for LRP1B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRP1B Gene

  • Aspartic acid and asparagine hydroxylation site
  • EGF-like calcium-binding
  • Low density lipoprotein-receptor, class A

Suggested Antigen Peptide Sequences for LRP1B Gene

GenScript: Design optimal peptide antigens:
  • Low-density lipoprotein receptor-related protein-deleted in tumor (LRP1B_HUMAN)
  • Candidate tumor suppressor protein (Q8WY26_HUMAN)
  • Candidate tumor suppressor protein (Q8WY27_HUMAN)
  • Candidate tumor suppressor protein (Q8WY28_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDLR family.
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP1B: view

Function for LRP1B Gene

Molecular function for LRP1B Gene

UniProtKB/Swiss-Prot Function:
Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Enzyme Numbers (IUBMB) for LRP1B Gene

Phenotypes From GWAS Catalog for LRP1B Gene

Gene Ontology (GO) - Molecular Function for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRP1B: view
genes like me logo Genes that share phenotypes with LRP1B: view

Animal Models for LRP1B Gene

MGI Knock Outs for LRP1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP1B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRP1B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRP1B Gene

Localization for LRP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP1B Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP1B gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with LRP1B: view

Pathways & Interactions for LRP1B Gene

PathCards logo

SuperPathways for LRP1B Gene

No Data Available

SIGNOR curated interactions for LRP1B Gene


Gene Ontology (GO) - Biological Process for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis TAS 10766186
GO:0015031 protein transport TAS 10766186
genes like me logo Genes that share ontologies with LRP1B: view

No data available for Pathways by source for LRP1B Gene

Drugs & Compounds for LRP1B Gene

(1) Drugs for LRP1B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
COG 133 Pharma ApoE mimetic peptide, ApoE peptide fragment 0

(1) ApexBio Compounds for LRP1B Gene

Compound Action Cas Number
COG 133 ApoE mimetic peptide 514200-66-9
genes like me logo Genes that share compounds with LRP1B: view

Drug Products

Transcripts for LRP1B Gene

mRNA/cDNA for LRP1B Gene

3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRP1B

Alternative Splicing Database (ASD) splice patterns (SP) for LRP1B Gene

No ASD Table

Relevant External Links for LRP1B Gene

GeneLoc Exon Structure for

Expression for LRP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRP1B Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for LRP1B Gene

This gene is overexpressed in Prostate (21.5), Breast (18.4), Neutrophil (13.6), and Ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRP1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRP1B

SOURCE GeneReport for Unigene cluster for LRP1B Gene:


mRNA Expression by UniProt/SwissProt for LRP1B Gene:

Tissue specificity: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.

Evidence on tissue expression from TISSUES for LRP1B Gene

  • Nervous system(3.6)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with LRP1B: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP1B Gene

Orthologs for LRP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP1B 30 31
  • 99.38 (n)
(Bos Taurus)
Mammalia LRP1B 31
  • 95 (a)
(Canis familiaris)
Mammalia LRP1B 30 31
  • 93.55 (n)
(Monodelphis domestica)
Mammalia LRP1B 31
  • 93 (a)
(Mus musculus)
Mammalia Lrp1b 30 17 31
  • 87.88 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
-- 31
  • 81 (a)
-- 31
  • 60 (a)
(Gallus gallus)
Aves LRP1B 30 31
  • 81.53 (n)
(Anolis carolinensis)
Reptilia LRP1B 31
  • 83 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrp1b 30
  • 76.06 (n)
(Danio rerio)
Actinopterygii lrp1bb 30 31
  • 68.54 (n)
lrp1ba 31 31
  • 65 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta yl 32
  • 27 (a)
(Caenorhabditis elegans)
Secernentea B0244.8 32
  • 34 (a)
R01H2.3 32
  • 34 (a)
T21E3.3 32
  • 29 (a)
F47B3.8 32
  • 28 (a)
F14B4.1 31
  • 27 (a)
rme-2 32
  • 25 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
Species where no ortholog for LRP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LRP1B Gene

Gene Tree for LRP1B (if available)
Gene Tree for LRP1B (if available)
Evolutionary constrained regions (ECRs) for LRP1B: view image

Paralogs for LRP1B Gene

Paralogs for LRP1B Gene

(14) SIMAP similar genes for LRP1B Gene using alignment to 20 proteins:

  • H0Y7T7_HUMAN
  • H7C0A8_HUMAN
  • Q4ZG53_HUMAN
  • Q53QM8_HUMAN
  • Q53QP5_HUMAN
  • Q53RA0_HUMAN
  • Q53RG4_HUMAN
  • Q53RL0_HUMAN
  • Q53S26_HUMAN
  • Q53S73_HUMAN
  • Q53S76_HUMAN
  • Q53TB8_HUMAN
  • Q580W7_HUMAN
  • Q8WY26_HUMAN
  • Q8WY27_HUMAN
  • Q8WY28_HUMAN
genes like me logo Genes that share paralogs with LRP1B: view

Variants for LRP1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRP1B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
713193 Benign: not provided 141,188,525(-) G/A SYNONYMOUS_VARIANT
718269 Likely Benign: not provided 140,324,047(-) C/T SYNONYMOUS_VARIANT
718270 Benign: not provided 140,700,613(-) C/A MISSENSE_VARIANT
718396 Benign: not provided 140,525,923(-) G/A SYNONYMOUS_VARIANT
718493 Likely Benign: not provided 141,229,332(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for LRP1B Gene

Structural Variations from Database of Genomic Variants (DGV) for LRP1B Gene

Variant ID Type Subtype PubMed ID
dgv161e55 CNV gain 17911159
dgv2048n106 CNV deletion 24896259
dgv2049n106 CNV deletion 24896259
dgv229n21 CNV gain 19592680
dgv4084n100 CNV loss 25217958
dgv477n27 CNV loss 19166990
dgv624e201 CNV deletion 23290073
dgv7089n54 CNV loss 21841781
dgv7090n54 CNV loss 21841781
dgv7091n54 CNV loss 21841781
dgv7092n54 CNV loss 21841781
dgv7093n54 CNV loss 21841781
dgv7094n54 CNV loss 21841781
dgv735e199 CNV deletion 23128226
dgv736e199 CNV deletion 23128226
dgv740e214 CNV loss 21293372
dgv741e214 CNV loss 21293372
esv1002626 CNV loss 20482838
esv1010724 CNV deletion 20482838
esv1011284 CNV insertion 20482838
esv1462127 CNV insertion 17803354
esv1511272 CNV insertion 17803354
esv1788294 CNV deletion 17803354
esv1935046 CNV deletion 18987734
esv2066444 CNV deletion 18987734
esv2151280 CNV deletion 18987734
esv2425365 CNV deletion 19546169
esv2480394 CNV deletion 19546169
esv2484504 CNV deletion 19546169
esv24931 CNV loss 19812545
esv2511578 CNV deletion 19546169
esv2658234 CNV deletion 23128226
esv2660530 CNV deletion 23128226
esv2667057 CNV deletion 23128226
esv2675340 CNV deletion 23128226
esv2677390 CNV deletion 23128226
esv2720896 CNV deletion 23290073
esv2720897 CNV deletion 23290073
esv2720899 CNV deletion 23290073
esv2720901 CNV deletion 23290073
esv2720902 CNV deletion 23290073
esv2720903 CNV deletion 23290073
esv2720904 CNV deletion 23290073
esv2720905 CNV deletion 23290073
esv2720907 CNV deletion 23290073
esv2720908 CNV deletion 23290073
esv2740831 CNV deletion 23290073
esv2759095 CNV gain 17122850
esv2760542 CNV loss 21179565
esv27616 CNV loss 19812545
esv2762863 CNV loss 21179565
esv3304086 CNV mobile element insertion 20981092
esv3304845 CNV mobile element insertion 20981092
esv3307222 CNV mobile element insertion 20981092
esv3307489 CNV mobile element insertion 20981092
esv3309210 CNV mobile element insertion 20981092
esv3309991 CNV mobile element insertion 20981092
esv3324439 CNV insertion 20981092
esv3332192 CNV insertion 20981092
esv3332892 CNV insertion 20981092
esv3349650 CNV insertion 20981092
esv3362252 CNV insertion 20981092
esv3373905 CNV insertion 20981092
esv3400567 CNV insertion 20981092
esv3411762 CNV insertion 20981092
esv3413350 CNV insertion 20981092
esv3424223 CNV insertion 20981092
esv3442921 CNV insertion 20981092
esv3560236 CNV deletion 23714750
esv3560245 CNV deletion 23714750
esv3560251 CNV deletion 23714750
esv3560256 CNV deletion 23714750
esv3560257 CNV deletion 23714750
esv3560261 CNV deletion 23714750
esv3560263 CNV deletion 23714750
esv3575304 CNV gain 25503493
esv3575306 CNV gain 25503493
esv3575307 CNV gain 25503493
esv3584091 CNV loss 25503493
esv3584092 CNV loss 25503493
esv3584094 CNV loss 25503493
esv3584095 CNV loss 25503493
esv3584096 CNV loss 25503493
esv3584097 CNV loss 25503493
esv3592680 CNV gain 21293372
esv3592685 CNV loss 21293372
esv3592686 CNV loss 21293372
esv3592687 CNV loss 21293372
esv3592693 CNV loss 21293372
esv3592696 CNV loss 21293372
esv3592698 CNV loss 21293372
esv3592699 CNV loss 21293372
esv3592700 CNV gain 21293372
esv3592701 CNV loss 21293372
esv3592704 CNV loss 21293372
esv3592707 CNV gain 21293372
esv3592708 CNV loss 21293372
esv3592710 CNV gain 21293372
esv3592712 CNV gain 21293372
esv3592713 CNV loss 21293372
esv3592716 CNV loss 21293372
esv3592718 CNV loss 21293372
esv3592719 CNV loss 21293372
esv3592721 CNV loss 21293372
esv3592723 CNV gain 21293372
esv3592725 CNV loss 21293372
esv3645 CNV loss 18987735
esv3893470 CNV loss 25118596
esv5978 CNV loss 19470904
esv9456 CNV loss 19470904
esv988978 CNV insertion 20482838
esv995362 CNV deletion 20482838
nsv1002168 CNV gain 25217958
nsv1003799 CNV loss 25217958
nsv1004207 CNV loss 25217958
nsv1004379 CNV gain 25217958
nsv1004494 CNV gain 25217958
nsv1009434 CNV loss 25217958
nsv1009893 CNV gain 25217958
nsv1010008 CNV loss 25217958
nsv1014208 CNV gain 25217958
nsv10196 CNV gain 18304495
nsv1071627 CNV deletion 25765185
nsv1072035 CNV deletion 25765185
nsv1116799 CNV deletion 24896259
nsv1117260 CNV tandem duplication 24896259
nsv1127767 CNV deletion 24896259
nsv1127768 CNV deletion 24896259
nsv1133072 OTHER inversion 24896259
nsv1136422 CNV deletion 24896259
nsv1136423 CNV deletion 24896259
nsv1136424 CNV deletion 24896259
nsv1138851 CNV deletion 24896259
nsv1138852 CNV deletion 24896259
nsv1140328 OTHER inversion 24896259
nsv1145802 CNV deletion 26484159
nsv1150176 CNV deletion 26484159
nsv1160872 CNV duplication 26073780
nsv214199 CNV insertion 16902084
nsv214324 CNV deletion 16902084
nsv214554 CNV insertion 16902084
nsv215437 CNV deletion 16902084
nsv2948 CNV insertion 18451855
nsv433205 CNV loss 18776910
nsv433206 CNV loss 18776910
nsv441788 CNV loss 18776908
nsv459496 CNV loss 19166990
nsv459507 CNV loss 19166990
nsv459518 CNV loss 19166990
nsv459529 CNV gain 19166990
nsv459574 CNV loss 19166990
nsv459585 CNV loss 19166990
nsv459596 CNV loss 19166990
nsv459618 CNV loss 19166990
nsv459629 CNV loss 19166990
nsv459640 CNV loss 19166990
nsv459651 CNV loss 19166990
nsv459674 CNV loss 19166990
nsv470488 CNV loss 18288195
nsv470489 CNV gain 18288195
nsv470490 CNV loss 18288195
nsv470491 CNV loss 18288195
nsv470492 CNV loss 18288195
nsv472667 CNV novel sequence insertion 20440878
nsv476188 CNV novel sequence insertion 20440878
nsv478130 CNV novel sequence insertion 20440878
nsv507037 OTHER sequence alteration 20534489
nsv508111 OTHER sequence alteration 20534489
nsv511815 CNV loss 21212237
nsv516298 CNV gain 19592680
nsv517341 CNV loss 19592680
nsv518726 CNV loss 19592680
nsv522093 CNV gain 19592680
nsv522203 CNV loss 19592680
nsv523571 CNV loss 19592680
nsv526107 CNV gain 19592680
nsv526332 CNV loss 19592680
nsv528276 CNV gain 19592680
nsv583189 CNV loss 21841781
nsv583190 CNV loss 21841781
nsv583191 CNV loss 21841781
nsv583192 CNV gain 21841781
nsv583193 CNV loss 21841781
nsv583198 CNV loss 21841781
nsv583199 CNV loss 21841781
nsv583200 CNV loss 21841781
nsv583201 CNV loss 21841781
nsv583202 CNV loss 21841781
nsv583203 CNV loss 21841781
nsv583204 CNV loss 21841781
nsv583205 CNV gain 21841781
nsv583206 CNV loss 21841781
nsv583207 CNV loss 21841781
nsv583208 CNV gain 21841781
nsv583209 CNV loss 21841781
nsv583212 CNV loss 21841781
nsv583213 CNV loss 21841781
nsv583214 CNV loss 21841781
nsv583224 CNV loss 21841781
nsv583233 CNV loss 21841781
nsv583234 CNV loss 21841781
nsv583235 CNV loss 21841781
nsv583236 CNV loss 21841781
nsv583237 CNV loss 21841781
nsv583238 CNV loss 21841781
nsv818086 CNV loss 17921354
nsv819672 CNV gain 19587683
nsv821736 CNV loss 20364138
nsv821737 CNV gain 20364138
nsv821738 CNV gain 20364138
nsv821739 CNV loss 20364138
nsv821740 CNV loss 20364138
nsv834392 CNV gain 17160897
nsv834393 CNV gain 17160897
nsv834394 CNV gain 17160897
nsv955257 CNV duplication 24416366
nsv956633 CNV deletion 24416366
nsv956676 CNV deletion 24416366
nsv956699 CNV deletion 24416366
nsv956704 CNV deletion 24416366
nsv963953 CNV deletion 23825009

Variation tolerance for LRP1B Gene

Residual Variation Intolerance Score: 0.446% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.88; 91.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRP1B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP1B Gene

Disorders for LRP1B Gene

MalaCards: The human disease database

(5) MalaCards diseases for LRP1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, idiopathic generalized 9
  • epilepsy, idiopathic generalized, susceptibility to, 9
meier-gorlin syndrome 2
  • mgors2
lung cancer
  • adenocarcinoma of lung
meningioma, familial
  • meningioma, familial, susceptibility to
polycystic kidney disease 4 with or without polycystic liver disease
  • pkd4
- elite association - COSMIC cancer census association via MalaCards
Search LRP1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LRP1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with LRP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRP1B Gene

Publications for LRP1B Gene

  1. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. (PMID: 11384978) Liu CX … Bu G (The Journal of biological chemistry 2001) 3 4 23
  2. LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. (PMID: 10766186) Liu CX … Lisitsyn NA (Cancer research 2000) 2 3 4
  3. Genomic organization of a new candidate tumor suppressor gene, LRP1B. (PMID: 11031110) Liu CX … Lisitsyn NA (Genomics 2000) 3 4 23
  4. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PMID: 20395239) Macgregor S … Mackey DA (Human molecular genetics 2010) 3 41
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for LRP1B Gene

  • Signalway Proteins for LRP1B

Sources for LRP1B Gene