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Aliases for LRP11 Gene

Aliases for LRP11 Gene

  • LDL Receptor Related Protein 11 2 3 5
  • LRP-11 3 4
  • Low-Density Lipoprotein Receptor-Related Protein 11 3
  • Low Density Lipoprotein Receptor-Related Protein 11 2
  • BA350J20.3 3
  • MANSC3 3

External Ids for LRP11 Gene

Previous GeneCards Identifiers for LRP11 Gene

  • GC06M150095
  • GC06M150170
  • GC06M150232
  • GC06M150139
  • GC06M147705

Summaries for LRP11 Gene

GeneCards Summary for LRP11 Gene

LRP11 (LDL Receptor Related Protein 11) is a Protein Coding gene. An important paralog of this gene is KIAA0319.

Additional gene information for LRP11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP11 Gene

Genomics for LRP11 Gene

GeneHancer (GH) Regulatory Elements for LRP11 Gene

Promoters and enhancers for LRP11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J149858 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 656.2 +2.2 2245 6.4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 LRP11 RAET1E-AS1 LOC100240714 ENSG00000231760 RAET1E LATS1 NUP43 ULBP1 ENSG00000273132
GH06J149886 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11.7 -24.9 -24857 5.2 MEIS2 JUN ZSCAN4 MAX CEBPG ZIC2 RFX5 ZNF335 GATA3 RCOR1 RAET1E LOC100240714 ENSG00000231760 LRP11 CCT7P1 RAET1E-AS1
GH06J149840 Enhancer 1.3 Ensembl ENCODE dbSUPER 13 +23.5 23497 1.5 FOXA2 ARID4B SIN3A ZNF48 SLC30A9 ARID2 ZNF143 FOS ATF7 MXD4 ENSG00000231760 LRP11 RAET1E GINM1 ENSG00000202343 ENSG00000233330 RPS18P9 ENSG00000273132 GC06P149237
GH06J149248 Enhancer 1.3 FANTOM5 Ensembl dbSUPER 10.6 +614.4 614447 2.6 HDGF FOXA2 ZSCAN4 YBX1 ZNF48 EGR1 ZNF366 KLF7 ETV6 IKZF2 LATS1 NUP43 PPIL4 KATNA1 LOC100240714 RAET1E-AS1 ENSG00000233330 RPS18P9 ENSG00000228408 ENSG00000231760
GH06J149894 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 6.7 -32.3 -32268 3.6 ELF3 FOXA2 ZSCAN4 RAD21 ZEB1 GTF3C2 RCOR1 ZNF548 FOS SP5 RAET1E NUP43 LATS1 LOC100240714 KATNA1 PPIL4 ENSG00000231760 LRP11 CCT7P1 RAET1E-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRP11 gene promoter:
  • Olf-1
  • YY1
  • E2F-1
  • E2F
  • FOXD3
  • Nkx5-1
  • MEF-2A
  • MEF-2
  • aMEF-2
  • NRSF form 1

Genomic Locations for LRP11 Gene

Genomic Locations for LRP11 Gene
69,161 bases
Minus strand
46,306 bases
Minus strand

Genomic View for LRP11 Gene

Genes around LRP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP11 Gene

Proteins for LRP11 Gene

  • Protein details for LRP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 11
    Protein Accession:
    Secondary Accessions:
    • Q5VYC0
    • Q96SN6

    Protein attributes for LRP11 Gene

    500 amino acids
    Molecular mass:
    53311 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRP11 Gene


neXtProt entry for LRP11 Gene

Post-translational modifications for LRP11 Gene

  • Glycosylation at posLast=401401, isoforms=386, isoforms=367, posLast=360360, isoforms=303, isoforms=293, isoforms=291, isoforms=2197, and posLast=164164
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP11 Gene

Antibody Products

  • Abcam antibodies for LRP11
  • Boster Bio Antibodies for LRP11
  • Santa Cruz Biotechnology (SCBT) Antibodies for LRP11

No data available for DME Specific Peptides for LRP11 Gene

Domains & Families for LRP11 Gene

Gene Families for LRP11 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LDLR family.
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP11: view

Function for LRP11 Gene

Phenotypes From GWAS Catalog for LRP11 Gene

Gene Ontology (GO) - Molecular Function for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051219 phosphoprotein binding IMP 17620599
genes like me logo Genes that share ontologies with LRP11: view
genes like me logo Genes that share phenotypes with LRP11: view

Animal Model Products

miRNA for LRP11 Gene

miRTarBase miRNAs that target LRP11

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP11 Gene

Localization for LRP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP11 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IC 17620599
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP11: view

Pathways & Interactions for LRP11 Gene

SuperPathways for LRP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009408 response to heat IEA --
GO:0009409 response to cold IEA --
GO:0009414 response to water deprivation IEA --
GO:0009612 response to mechanical stimulus IEA --
GO:0033555 multicellular organismal response to stress IEA --
genes like me logo Genes that share ontologies with LRP11: view

No data available for Pathways by source and SIGNOR curated interactions for LRP11 Gene

Drugs & Compounds for LRP11 Gene

No Compound Related Data Available

Transcripts for LRP11 Gene

mRNA/cDNA for LRP11 Gene

Unigene Clusters for LRP11 Gene

Low density lipoprotein receptor-related protein 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP11 Gene

No ASD Table

Relevant External Links for LRP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRP11 Gene

Protein differential expression in normal tissues from HIPED for LRP11 Gene

This gene is overexpressed in Cerebrospinal fluid (25.7), Saliva (24.4), and Plasma (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRP11 Gene

Protein tissue co-expression partners for LRP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRP11 Gene:


SOURCE GeneReport for Unigene cluster for LRP11 Gene:


Evidence on tissue expression from TISSUES for LRP11 Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with LRP11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP11 Gene

Orthologs for LRP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP11 34 33
  • 99.6 (n)
(Canis familiaris)
Mammalia LRP11 34 33
  • 87.25 (n)
(Bos Taurus)
Mammalia LRP11 34 33
  • 84.74 (n)
(Rattus norvegicus)
Mammalia Lrp11 33
  • 78.59 (n)
(Mus musculus)
Mammalia Lrp11 16 34 33
  • 78.11 (n)
(Monodelphis domestica)
Mammalia LRP11 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia LRP11 34
  • 54 (a)
(Gallus gallus)
Aves LRP11 34 33
  • 69.58 (n)
(Anolis carolinensis)
Reptilia LRP11 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp11 33
  • 61.79 (n)
Str.12474 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25624 33
(Danio rerio)
Actinopterygii lrp11 33
  • 59.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3864 34
  • 30 (a)
Species where no ortholog for LRP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP11 Gene

Gene Tree for LRP11 (if available)
Gene Tree for LRP11 (if available)
Evolutionary constrained regions (ECRs) for LRP11: view image

Paralogs for LRP11 Gene

Paralogs for LRP11 Gene

genes like me logo Genes that share paralogs with LRP11: view

Variants for LRP11 Gene

Sequence variations from dbSNP and Humsavar for LRP11 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000023965 -- 149,830,258(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000045692 -- 149,854,765(-) C/T intron_variant
rs1000059103 -- 149,837,813(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000084836 -- 149,860,879(-) G/A intron_variant
rs1000191831 -- 149,843,231(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRP11 Gene

Variant ID Type Subtype PubMed ID
esv3356372 CNV insertion 20981092
nsv517022 CNV gain+loss 19592680
nsv823860 CNV gain 20364138

Variation tolerance for LRP11 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.75; 91.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP11 Gene

Disorders for LRP11 Gene

Additional Disease Information for LRP11

No disorders were found for LRP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP11 Gene

Publications for LRP11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for LRP11 Gene

Sources for LRP11 Gene

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