This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016] See more...

Aliases for LRP10 Gene

Aliases for LRP10 Gene

  • LDL Receptor Related Protein 10 2 3 5
  • Low-Density Lipoprotein Receptor-Related Protein 10 3 4
  • MSTP087 2 3
  • LRP-10 3 4
  • MST087 2 3
  • LRP9 2 3
  • Low Density Lipoprotein Receptor-Related Protein 10 2
  • DKFZP564C1940 2
  • MGC8675 2
  • LRP10 5

External Ids for LRP10 Gene

Previous GeneCards Identifiers for LRP10 Gene

  • GC14P020717
  • GC14P017128
  • GC14P021331
  • GC14P022410
  • GC14P023340
  • GC14P003458

Summaries for LRP10 Gene

Entrez Gene Summary for LRP10 Gene

  • This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]

GeneCards Summary for LRP10 Gene

LRP10 (LDL Receptor Related Protein 10) is a Protein Coding gene. Diseases associated with LRP10 include Ovarian Embryonal Carcinoma and Angiostrongyliasis. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. An important paralog of this gene is LRP3.

UniProtKB/Swiss-Prot Summary for LRP10 Gene

  • Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Wiki entry for LRP10 Gene

Additional gene information for LRP10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRP10 Gene

Genomics for LRP10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRP10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRP10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRP10

Top Transcription factor binding sites by QIAGEN in the LRP10 gene promoter:
  • AML1a
  • ATF
  • E47
  • Hand1
  • HTF
  • NF-1
  • NF-1/L
  • Pax-4a
  • ZID

Genomic Locations for LRP10 Gene

Genomic Locations for LRP10 Gene
chr14:22,871,613-22,881,713
(GRCh38/hg38)
Size:
10,101 bases
Orientation:
Plus strand
chr14:23,340,822-23,350,789
(GRCh37/hg19)
Size:
9,968 bases
Orientation:
Plus strand

Genomic View for LRP10 Gene

Genes around LRP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP10 Gene

Proteins for LRP10 Gene

  • Protein details for LRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4F1-LRP10_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 10
    Protein Accession:
    Q7Z4F1
    Secondary Accessions:
    • A8K4R5
    • D3DS31
    • O95882
    • Q14CK7
    • Q86T02
    • Q8NCZ4
    • Q9HC42
    • Q9UG33

    Protein attributes for LRP10 Gene

    Size:
    713 amino acids
    Molecular mass:
    76193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20037.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG17980.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAQ13610.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP10 Gene

Post-translational modifications for LRP10 Gene

  • Glycosylation at Asn56, Asn111, Asn193, and Asn299
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • LRP10_HUMAN (1465)

Other Protein References for LRP10 Gene

No data available for DME Specific Peptides for LRP10 Gene

Domains & Families for LRP10 Gene

Gene Families for LRP10 Gene

Protein Domains for LRP10 Gene

InterPro:
Blocks:
  • CUB domain
  • Low density lipoprotein-receptor, class A
ProtoNet:

Suggested Antigen Peptide Sequences for LRP10 Gene

GenScript: Design optimal peptide antigens:
  • Low-density lipoprotein receptor-related protein 10 (LRP10_HUMAN)
  • LRP10 protein (Q5I0F9_HUMAN)
  • LRP10 protein (Q66K21_HUMAN)
  • LRP10 protein (Q6IAK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4F1

UniProtKB/Swiss-Prot:

LRP10_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP10: view

Function for LRP10 Gene

Molecular function for LRP10 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Phenotypes From GWAS Catalog for LRP10 Gene

Gene Ontology (GO) - Molecular Function for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein particle receptor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRP10: view
genes like me logo Genes that share phenotypes with LRP10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP10

CRISPR Products

miRNA for LRP10 Gene

miRTarBase miRNAs that target LRP10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRP10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP10 Gene

Localization for LRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP10 Gene

Membrane. Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP10 gene
Compartment Confidence
plasma membrane 3
extracellular 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005905 clathrin-coated pit IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP10: view

Pathways & Interactions for LRP10 Gene

genes like me logo Genes that share pathways with LRP10: view

Gene Ontology (GO) - Biological Process for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0006897 endocytosis IEA --
GO:0048839 inner ear development IEA --
genes like me logo Genes that share ontologies with LRP10: view

No data available for SIGNOR curated interactions for LRP10 Gene

Drugs & Compounds for LRP10 Gene

No Compound Related Data Available

Transcripts for LRP10 Gene

mRNA/cDNA for LRP10 Gene

2 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRP10

Alternative Splicing Database (ASD) splice patterns (SP) for LRP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for LRP10 Gene

GeneLoc Exon Structure for
LRP10

Expression for LRP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRP10 Gene

mRNA differential expression in normal tissues according to GTEx for LRP10 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for LRP10 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRP10 Gene



Protein tissue co-expression partners for LRP10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRP10

SOURCE GeneReport for Unigene cluster for LRP10 Gene:

Hs.525232

mRNA Expression by UniProt/SwissProt for LRP10 Gene:

Q7Z4F1-LRP10_HUMAN
Tissue specificity: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for LRP10 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Intestine(3.9)
  • Pancreas(3.6)
  • Blood(2.7)
  • Kidney(2.6)
  • Skin(2.5)
  • Muscle(2.4)
  • Stomach(2.3)
  • Heart(2.1)
  • Liver(2.1)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with LRP10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP10 Gene

Orthologs for LRP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRP10 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRP10 30 31
  • 87.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRP10 30 31
  • 87.11 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrp10 30 17 31
  • 85.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrp10 30
  • 85.33 (n)
Oppossum
(Monodelphis domestica)
Mammalia LRP10 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRP10 31
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LRP10 31
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia lrp10 30
  • 53.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5830 30
Zebrafish
(Danio rerio)
Actinopterygii LOC560361 30
  • 49.9 (n)
LRP10 31
  • 39 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta ImpE1 31
  • 8 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea M03E7.4 31
  • 19 (a)
OneToMany
Species where no ortholog for LRP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for LRP10 Gene

ENSEMBL:
Gene Tree for LRP10 (if available)
TreeFam:
Gene Tree for LRP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRP10: view image

Paralogs for LRP10 Gene

Paralogs for LRP10 Gene

(3) SIMAP similar genes for LRP10 Gene using alignment to 5 proteins:

  • LRP10_HUMAN
  • H0YHW7_HUMAN
  • Q5I0F9_HUMAN
  • Q66K21_HUMAN
  • Q6IAK3_HUMAN
genes like me logo Genes that share paralogs with LRP10: view

Variants for LRP10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRP10 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs568022752 Uncertain Significance: Exstrophy-epispadias complex 22,875,702(+) G/A MISSENSE_VARIANT
rs2273837 - p.Arg48Trp
rs28534929 - p.Met139Val

Additional dbSNP identifiers (rs#s) for LRP10 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRP10 Gene

Variant ID Type Subtype PubMed ID
nsv1214 CNV deletion 18451855
nsv563998 CNV gain 21841781

Variation tolerance for LRP10 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRP10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP10 Gene

Disorders for LRP10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRP10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian embryonal carcinoma
  • embryonal carcinoma of ovary
angiostrongyliasis
- elite association - COSMIC cancer census association via MalaCards
Search LRP10 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with LRP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRP10 Gene

Publications for LRP10 Gene

  1. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (PMID: 11123907) Sugiyama T … Kitamura T (Biochemistry 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 3 4

Products for LRP10 Gene

  • Signalway ELISA kits for LRP10

Sources for LRP10 Gene