Aliases for LRP1 Gene
- LDL Receptor Related Protein 1 2 3 5
- Alpha-2-Macroglobulin Receptor 2 3 4
- APOER 2 3 4
- Prolow-Density Lipoprotein Receptor-Related Protein 1 3 4
- Low Density Lipoprotein Receptor-Related Protein 1 2 3
- Apolipoprotein E Receptor 3 4
- LRP1A 2 3
- A2MR 3 4
- CD91 2 3
- APR 3 4
- LRP 2 3
- Transforming Growth Factor-β Receptor Type V 2
External Ids for LRP1 Gene
Previous HGNC Symbols for LRP1 Gene
Previous GeneCards Identifiers for LRP1 Gene
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
GeneCards Summary for LRP1 Gene
LRP1 (LDL Receptor Related Protein 1) is a Protein Coding gene. Diseases associated with LRP1 include Keratosis Pilaris Atrophicans and Atrophoderma Vermiculata. Among its related pathways are Statin Pathway and Binding and Uptake of Ligands by Scavenger Receptors. An important paralog of this gene is LRP1B.
UniProtKB/Swiss-Prot Summary for LRP1 Gene
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).
(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.