Free for academic non-profit institutions. Other users need a Commercial license
LRIG3 (Leucine Rich Repeats And Immunoglobulin Like Domains 3) is a Protein Coding gene. Diseases associated with LRIG3 include Cervical Adenocarcinoma and Urofacial Syndrome 1. An important paralog of this gene is LRIG2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 23723069 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0032474 | otolith morphogenesis | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LRIG3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LRIG3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LRIG3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lrig3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lrig3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LRIG3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LRIG3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LRIG3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LRIG3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lrig3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | lrig3 30 |
|
||
LRIG3 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | lbk 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009688 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | sma-10 30 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs138577440 | Likely Benign: not provided | 58,886,850(-) |
T/C NM_153377.4(LRIG3):c.1132A>G (p.Met378Val) |
MISSENSE | |
rs182093691 | Benign: not provided | 58,876,446(-) |
A/T NM_153377.4(LRIG3):c.2694T>A (p.Ser898Arg) |
MISSENSE | |
rs530909599 | Benign: not provided | 58,876,497(-) |
CTGG/C NM_001136051.2(LRIG3):c.2454_2456CCA[2] (p.His820del) |
INFRAME_DELETION |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759902 | CNV | gain | 17122850 |
nsv733 | CNV | insertion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cervical adenocarcinoma |
|
|
urofacial syndrome 1 |
|
|
charcot-marie-tooth disease |
|
|