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LRIG3 Gene(Protein Coding)

Leucine Rich Repeats And Immunoglobulin Like Domains 3

GCID:
GC12M058872
GIFtS:
45
Genes Participants
UDN Logo

Aliases for LRIG3 Gene

Aliases for LRIG3 Gene

  • Leucine Rich Repeats And Immunoglobulin Like Domains 3 2 3 5
  • LIG-3 3 4
  • LIG3 3 4
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 3 3

External Ids for LRIG3 Gene

Previous GeneCards Identifiers for LRIG3 Gene

  • GC12M057553
  • GC12M057554
  • GC12M059265
  • GC12M056314

Summaries for LRIG3 Gene

GeneCards Summary for LRIG3 Gene

LRIG3 (Leucine Rich Repeats And Immunoglobulin Like Domains 3) is a Protein Coding gene. An important paralog of this gene is LRIG2.

UniProtKB/Swiss-Prot for LRIG3 Gene

  • May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

Additional gene information for LRIG3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG3 Gene

Genomics for LRIG3 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for LRIG3 Gene

Promoters and enhancers for LRIG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I058913 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.2 +1.6 1631 9.9 PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRIG3 ENSG00000257443 LOC105369791 LINC02388
GH12I058527 Enhancer 1.1 FANTOM5 Ensembl ENCODE 15 +390.6 390618 3.9 FOXA2 JUN MAFG MNT FOXA1 MAFF JUND ZNF316 POLR2A FOSL2 LRIG3 CTDSP2 LOC100506869 GC12M058472
GH12I058876 Enhancer 0.8 ENCODE 15.3 +42.5 42475 3.9 PKNOX1 CLOCK FOXA2 NFIB NEUROD1 MZF1 SIN3A ZBTB7B RAD21 ZNF366 LRIG3 LINC02388
GH12I058887 Enhancer 0.6 ENCODE 17.1 +32.3 32255 1.5 RXRA REST RAD21 ZNF316 SCRT2 FOXP2 HNF4A ZBTB33 MAFK LRIG3 LINC02388
GH12I058949 Enhancer 0.5 ENCODE 17.9 -30.1 -30084 1.7 SCRT1 YY2 SCRT2 ZNF398 FOS ZIC2 GC12P058951 GC12P058953 PIR32931 LRIG3 LOC105369791 ENSG00000257443
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRIG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRIG3 gene promoter:

Genomic Locations for LRIG3 Gene

Genomic Locations for LRIG3 Gene
chr12:58,872,149-58,920,538
(GRCh38/hg38)
Size:
48,390 bases
Orientation:
Minus strand
chr12:59,265,931-59,314,303
(GRCh37/hg19)

Genomic View for LRIG3 Gene

Genes around LRIG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRIG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRIG3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LRIG3 Gene

Proteins for LRIG3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LRIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXM1-LRIG3_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 3
    Protein Accession:
    Q6UXM1
    Secondary Accessions:
    • Q6UXL7
    • Q8NC72

    Protein attributes for LRIG3 Gene

    Size:
    1119 amino acids
    Molecular mass:
    123434 Da
    Quaternary structure:
    • Interacts with EGFR, ERBB2 and ERBB4 (in vitro).
    SequenceCaution:
    • Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRIG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIG3 Gene

Protein Expression for LRIG3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LRIG3 Gene

  • Glycosylation at posLast=122122, isoforms=2156, isoforms=2274, isoforms=2442, posLast=469469, isoforms=2515, isoforms=2688, posLast=729729, posLast=905905, posLast=987987, isoforms=2999, and posLast=10161016
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRIG3 Gene

Domains & Families for LRIG3 Gene

Gene Families for LRIG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRIG3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRIG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRIG3: view

No data available for UniProtKB/Swiss-Prot for LRIG3 Gene

Function for LRIG3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LRIG3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

Phenotypes From GWAS Catalog for LRIG3 Gene

genes like me logo Genes that share phenotypes with LRIG3: view

Animal Models for LRIG3 Gene

MGI Knock Outs for LRIG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRIG3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRIG3 Gene

Localization for LRIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG3 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRIG3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with LRIG3: view

Pathways & Interactions for LRIG3 Gene

SuperPathways for LRIG3 Gene

PathCards logo More details on SuperPathways for LRIG3
No Data Available

SIGNOR curated interactions for LRIG3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0032474 otolith morphogenesis IEA --
genes like me logo Genes that share ontologies with LRIG3: view

No data available for Pathways by source for LRIG3 Gene

Drugs & Compounds for LRIG3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for LRIG3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LRIG3 Gene

(4) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRIG3 Gene

Leucine-rich repeats and immunoglobulin-like domains 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG3 Gene

No ASD Table

Relevant External Links for LRIG3 Gene

GeneLoc Exon Structure for
LRIG3
ECgene alternative splicing isoforms for
LRIG3

Expression for LRIG3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRIG3 Gene

mRNA expression in normal human tissues for LRIG3 Gene
mRNA expression by GTEx for LRIG3 GenemRNA expression by BioGPS for LRIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRIG3 Gene

This gene is overexpressed in Platelet (53.8) and Heart (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRIG3 Gene



Protein tissue co-expression partners for LRIG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRIG3 Gene:

LRIG3

SOURCE GeneReport for Unigene cluster for LRIG3 Gene:

Hs.253736

mRNA Expression by UniProt/SwissProt for LRIG3 Gene:

Q6UXM1-LRIG3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LRIG3: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRIG3 Gene

Orthologs for LRIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LRIG3 33 34
  • 99.29 (n)
dog
(Canis familiaris)
 Mammalia LRIG3 33 34
  • 90.93 (n)
cow
(Bos Taurus)
 Mammalia LRIG3 33 34
  • 89.19 (n)
rat
(Rattus norvegicus)
 Mammalia Lrig3 33
  • 83.93 (n)
mouse
(Mus musculus)
 Mammalia Lrig3 33 16 34
  • 83.65 (n)
oppossum
(Monodelphis domestica)
 Mammalia LRIG3 34
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia LRIG3 34
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LRIG3 33 34
  • 76.06 (n)
lizard
(Anolis carolinensis)
 Reptilia LRIG3 34
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lrig3 33
  • 69.98 (n)
zebrafish
(Danio rerio)
 Actinopterygii lrig3 33
  • 64.84 (n)
LRIG3 34
  • 60 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta lbk 33 34
  • 47.47 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009688 33
  • 27.09 (n)
worm
(Caenorhabditis elegans)
 Secernentea sma-10 33 34
  • 44.38 (n)
Species where no ortholog for LRIG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG3 Gene

ENSEMBL:
Gene Tree for LRIG3 (if available)
TreeFam:
Gene Tree for LRIG3 (if available)

Paralogs for LRIG3 Gene

Variants for LRIG3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for LRIG3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000099126 -- 58,910,385(-) G/A intron_variant
rs1000115783 -- 58,870,215(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000170081 -- 58,881,805(-) G/A intron_variant
rs1000219930 -- 58,875,321(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000396533 -- 58,887,309(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG3 Gene

Variant ID Type Subtype PubMed ID
esv2759902 CNV gain 17122850
nsv733 CNV insertion 18451855

Variation tolerance for LRIG3 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRIG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRIG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG3 Gene

Disorders for LRIG3 Gene

Additional Disease Information for LRIG3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRIG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRIG3 Gene

Publications for LRIG3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith NL … Vasan RS (Circulation. Cardiovascular genetics 2010) 3 44 58
  3. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PMID: 20446891) Andersson U … Melin B (Acta oncologica (Stockholm, Sweden) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PMID: 15203213) Guo D … Hedman H (Genomics 2004) 3 4 58

Products for LRIG3 Gene

Sources for LRIG3 Gene

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