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This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in mul... See more...
Aliases for LRIG2 Gene
Aliases for LRIG2 Gene
External Ids for LRIG2 Gene
- HGNC: 20889
- Entrez Gene: 9860
- Ensembl: ENSG00000198799
- OMIM: 608869
- UniProtKB: O94898
Previous GeneCards Identifiers for LRIG2 Gene
- GC01P112715
- GC01P112914
- GC01P113327
- GC01P113417
- GC01P113615
- GC01P111474
Summaries for LRIG2 Gene
-
This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
GeneCards Summary for LRIG2 Gene
LRIG2 (Leucine Rich Repeats And Immunoglobulin Like Domains 2) is a Protein Coding gene. Diseases associated with LRIG2 include Urofacial Syndrome 2 and Urofacial Syndrome 1. An important paralog of this gene is LRIG3.
Additional gene information for LRIG2 Gene
- HGNC(20889)
- Entrez Gene(9860)
- Ensembl(ENSG00000198799)
- OMIM(608869)
- UniProtKB(O94898)
- Open Targets Platform(ENSG00000198799)
- Monarch Initiative
- Search for LRIG2 at DataMed
- Search for LRIG2 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRIG2 Gene
Genomics for LRIG2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for LRIG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around LRIG2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRIG2
- Top Transcription factor binding sites by QIAGEN in the LRIG2 gene promoter:
-
- aMEF-2
- AP-4
- Cart-1
- En-1
- MEF-2
- MEF-2A
- MIF-1
- NRSF form 1
- NRSF form 2
- TGIF
Genomic Locations for LRIG2 Gene
Genomic Locations for LRIG2 Gene
- chr1:113,073,170-113,132,260
- (GRCh38/hg38)
- Size:
- 59,091 bases
- Orientation:
- Plus strand
- chr1:113,615,831-113,674,882
- (GRCh37/hg19)
- Size:
- 59,052 bases
- Orientation:
- Plus strand
Genomic View for LRIG2 Gene
Genes around LRIG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
LRIG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LRIG2 Gene
Proteins for LRIG2 Gene
-
Protein details for LRIG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94898-LRIG2_HUMAN
- Recommended name:
- Leucine-rich repeats and immunoglobulin-like domains protein 2
- Protein Accession:
- O94898
- Q9NSN2
Protein attributes for LRIG2 Gene
- Size:
- 1065 amino acids
- Molecular mass:
- 118965 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA34526.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for LRIG2 Gene
Post-translational modifications for LRIG2 Gene
Other Protein References for LRIG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents LRIG2 Antibody
- Novus Biologicals Antibodies for LRIG2
- Invitrogen Antibodies for LRIG2 (AFLGC-Lrig2)
- antibodies-online: Show 7 available LRIG2 Antibodies ranked by validation data
-
Biorbyt antibodies for LRIG2
- Sino Biological Antibodies for LRIG2
Protein Products
-
OriGene Purified Proteins for LRIG2
- Search Origene for MassSpec and Protein Over-expression Lysates for LRIG2
- Origene Custom Protein Services for LRIG2
- Novus Biologicals proteins for LRIG2
No data available for DME Specific Peptides for LRIG2 Gene
Domains & Families for LRIG2 Gene
Gene Families for LRIG2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted membrane proteins
Protein Domains for LRIG2 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Immunoglobulin subtype
- Leucine-rich repeat signature
- Cysteine-rich flanking region, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for LRIG2 Gene
- GenScript: Design optimal peptide antigens:
-
- Leucine-rich repeats and immunoglobulin-like domains protein 2 (LRIG2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRIG2 Gene
Function for LRIG2 Gene
Phenotypes From GWAS Catalog for LRIG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 25353163 |
Phenotypes for LRIG2 Gene
- MGI mutant phenotypes for LRIG2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for LRIG2:
Animal Models for LRIG2 Gene
- MGI Knock Outs for LRIG2:
-
- Lrig2 Lrig2<tm1.1Hhed>
Animal Model Products
-
Taconic Biosciences Mouse Models for LRIG2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LRIG2 - Select products 50% OFF >
- * LRIG2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LRIG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRIG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRIG2
miRNA for LRIG2 Gene
- miRTarBase miRNAs that target LRIG2
-
- mmu-miR-425-5p (MIRT008780)
- mmu-miR-15a-5p (MIRT011970)
- mmu-let-7b-5p (MIRT012317)
- mmu-miR-34b-5p (MIRT012873)
- mmu-miR-181a-5p (MIRT014403)
- mmu-miR-9-5p (MIRT015608)
- hsa-miR-6875-3p (MIRT474027)
- hsa-miR-4531 (MIRT474028)
- hsa-miR-3190-3p (MIRT474029)
- hsa-miR-4516 (MIRT474030)
- hsa-miR-5703 (MIRT474031)
- hsa-miR-4434 (MIRT474032)
- hsa-miR-4795-5p (MIRT474033)
- hsa-miR-34a-3p (MIRT474034)
- hsa-miR-4503 (MIRT502018)
- hsa-miR-1200 (MIRT502020)
- hsa-miR-6792-5p (MIRT502021)
- hsa-miR-378a-5p (MIRT502022)
- hsa-miR-6820-3p (MIRT502023)
- hsa-miR-3164 (MIRT502024)
- hsa-miR-3118 (MIRT502025)
- hsa-miR-134-5p (MIRT502026)
- hsa-miR-4522 (MIRT502027)
- hsa-miR-1236-3p (MIRT502028)
- hsa-miR-338-3p (MIRT502029)
- hsa-miR-4530 (MIRT502030)
- hsa-miR-4501 (MIRT502031)
- hsa-miR-5586-5p (MIRT502032)
- hsa-miR-3908 (MIRT502033)
- hsa-miR-6838-5p (MIRT502034)
- hsa-miR-8066 (MIRT502035)
- hsa-miR-424-5p (MIRT502036)
- hsa-miR-195-5p (MIRT502037)
- hsa-miR-15a-5p (MIRT502038)
- hsa-miR-15b-5p (MIRT502039)
- hsa-miR-16-5p (MIRT502040)
- hsa-miR-497-5p (MIRT502041)
- hsa-miR-4684-5p (MIRT536240)
- hsa-miR-3163 (MIRT536241)
- hsa-miR-4282 (MIRT536242)
- hsa-miR-548c-3p (MIRT536243)
- hsa-miR-758-3p (MIRT566891)
- hsa-miR-8070 (MIRT566892)
- hsa-miR-1273e (MIRT566893)
- hsa-miR-6807-5p (MIRT566894)
- hsa-miR-1233-3p (MIRT566895)
- hsa-miR-1225-3p (MIRT566896)
- hsa-miR-6840-3p (MIRT566897)
- hsa-miR-665 (MIRT566898)
- hsa-miR-4433a-3p (MIRT566899)
- mmu-miR-186-5p (MIRT594880)
- mmu-miR-101b-3p (MIRT596185)
- mmu-miR-101a-3p (MIRT596186)
- mmu-miR-144-3p (MIRT596187)
- mmu-miR-802-5p (MIRT596188)
- mmu-miR-344d-3p (MIRT596189)
- mmu-miR-410-3p (MIRT596190)
- mmu-miR-344e-3p (MIRT596191)
- mmu-miR-1192 (MIRT606345)
- mmu-miR-495-3p (MIRT606346)
- hsa-miR-8485 (MIRT610717)
- hsa-miR-377-3p (MIRT615666)
- hsa-miR-6837-3p (MIRT615667)
- hsa-miR-6754-3p (MIRT615668)
- hsa-miR-412-3p (MIRT615669)
- hsa-miR-6731-3p (MIRT615670)
- hsa-miR-888-3p (MIRT623368)
- hsa-miR-7977 (MIRT623369)
- hsa-miR-4266 (MIRT623370)
- hsa-miR-24-3p (MIRT623371)
- hsa-miR-4284 (MIRT623372)
- hsa-miR-6089 (MIRT623373)
- hsa-miR-383-3p (MIRT623374)
- hsa-miR-4779 (MIRT623375)
- hsa-miR-4695-5p (MIRT623376)
- hsa-miR-5684 (MIRT623377)
- hsa-miR-6513-5p (MIRT634562)
- hsa-miR-887-5p (MIRT634563)
- hsa-miR-3913-5p (MIRT634564)
- hsa-miR-3122 (MIRT634565)
- hsa-miR-450a-1-3p (MIRT634566)
- hsa-miR-6780a-5p (MIRT634567)
- hsa-miR-6779-5p (MIRT634568)
- hsa-miR-3689c (MIRT634569)
- hsa-miR-3689b-3p (MIRT634570)
- hsa-miR-3689a-3p (MIRT634571)
- hsa-miR-30b-3p (MIRT634572)
- hsa-miR-1273h-5p (MIRT634573)
- hsa-miR-6788-5p (MIRT634574)
- hsa-miR-30c-2-3p (MIRT634575)
- hsa-miR-30c-1-3p (MIRT634576)
- hsa-miR-6799-5p (MIRT634577)
- hsa-miR-6883-5p (MIRT634578)
- hsa-miR-6785-5p (MIRT634579)
- hsa-miR-4728-5p (MIRT634580)
- hsa-miR-149-3p (MIRT634581)
- hsa-miR-7106-5p (MIRT634582)
- hsa-miR-5698 (MIRT667533)
- hsa-miR-6836-3p (MIRT667534)
- hsa-miR-5001-3p (MIRT667535)
- hsa-miR-143-5p (MIRT667536)
- hsa-miR-6829-3p (MIRT667537)
- hsa-miR-6791-3p (MIRT667538)
- hsa-miR-6499-3p (MIRT667539)
- hsa-miR-6778-3p (MIRT667540)
- hsa-miR-4772-3p (MIRT667541)
- hsa-miR-4638-5p (MIRT667542)
- hsa-miR-1307-3p (MIRT667543)
- hsa-miR-1304-3p (MIRT667544)
- hsa-miR-6741-3p (MIRT667545)
- hsa-miR-6890-3p (MIRT667546)
- hsa-miR-1288-5p (MIRT667547)
- hsa-miR-423-3p (MIRT673282)
- hsa-miR-6786-5p (MIRT673283)
- hsa-miR-25-5p (MIRT687626)
- hsa-miR-6087 (MIRT687627)
- hsa-miR-5186 (MIRT687628)
- hsa-miR-3192-5p (MIRT687629)
- hsa-miR-7851-3p (MIRT687630)
- hsa-miR-490-3p (MIRT687631)
- hsa-miR-6770-5p (MIRT725394)
- hsa-miR-1253 (MIRT725395)
- hsa-miR-4679 (MIRT725396)
- hsa-miR-6761-5p (MIRT725397)
- hsa-miR-4251 (MIRT725398)
- hsa-miR-4329 (MIRT725399)
- hsa-miR-195-3p (MIRT725400)
- hsa-miR-16-2-3p (MIRT725401)
- hsa-miR-3200-5p (MIRT725402)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRIG2
- Browse OriGene Inhibitory RNA Products For LRIG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRIG2
Clone Products
- Applied Biological Materials (abm): Clones for LRIG2 - Select products 50% OFF >
- * LRIG2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LRIG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRIG2
Cell Line Products
-
Horizon Cell Lines for LRIG2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LRIG2 Gene
Localization for LRIG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LRIG2 Gene
- Cell membrane. Single-pass type I membrane protein. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 3 |
| nucleus | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for LRIG2 Gene
Interacting Proteins for LRIG2 Gene
Selected Interacting proteins:
O94898-LRIG2_HUMAN
ENSP00000355396
for LRIG2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for LRIG2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007605 | sensory perception of sound | IEA | -- |
| GO:0010640 | regulation of platelet-derived growth factor receptor signaling pathway | IEA | -- |
| GO:0010977 | negative regulation of neuron projection development | IEA | -- |
| GO:0048679 | regulation of axon regeneration | IEA | -- |
| GO:0048681 | negative regulation of axon regeneration | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for LRIG2 Gene
Transcripts for LRIG2 Gene
mRNA/cDNA for LRIG2 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000361127 11566 nts (view in UCSC)
- ENST00000466069 564 nts (view in UCSC)
- ENST00000466161 3366 nts (view in UCSC)
- ENST00000470000 365 nts (view in UCSC)
- ENST00000492207 5076 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for LRIG2 - Select products 50% OFF >
- * LRIG2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for LRIG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LRIG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for LRIG2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LRIG2
- Browse OriGene Inhibitory RNA Products For LRIG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRIG2
Clone Products
- Applied Biological Materials (abm): Clones for LRIG2 - Select products 50% OFF >
- * LRIG2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for LRIG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LRIG2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - |
| ExUns: | 20a | · | 20b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: |
Relevant External Links for LRIG2 Gene
- GeneLoc Exon Structure for
- LRIG2
Expression for LRIG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRIG2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRIG2
SOURCE GeneReport for Unigene cluster for LRIG2 Gene:
Hs.448972mRNA Expression by UniProt/SwissProt for LRIG2 Gene:
O94898-LRIG2_HUMAN
Tissue specificity:
Detected in all tissues analyzed.
Evidence on tissue expression from TISSUES for LRIG2 Gene
- Nervous system(4.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for LRIG2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- cranial nerve
- face
- head
- skull
Abdomen:
- intestine
- kidney
- large intestine
Pelvis:
- rectum
- testicle
- ureter
- urethra
- urinary bladder
General:
- blood
- peripheral nerve
- peripheral nervous system
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for LRIG2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for LRIG2 Gene
Orthologs for LRIG2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LRIG2 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LRIG2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LRIG2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lrig2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lrig2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | LRIG2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | LRIG2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LRIG2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | LRIG2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lrig2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lrig2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | lbk 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | sma-10 31 |
|
OneToMany |
- Species where no ortholog for LRIG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for LRIG2 Gene
- ENSEMBL:
- Gene Tree for LRIG2 (if available)
- TreeFam:
- Gene Tree for LRIG2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LRIG2: view image
Paralogs for LRIG2 Gene
Paralogs for LRIG2 Gene
(4) SIMAP similar genes for LRIG2 Gene using alignment to 1 proteins:
- LRIG2_HUMAN
Variants for LRIG2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRIG2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 666570 | Likely Pathogenic: Urofacial syndrome 2 | 113,112,476(+) | CAG/C | ||
| 708509 | Likely Benign: not provided | 113,119,351(+) | A/G | SYNONYMOUS_VARIANT | |
| 709189 | Likely Benign: not provided | 113,100,474(+) | T/C | SYNONYMOUS_VARIANT | |
| 714080 | Likely Benign: not provided | 113,073,412(+) | G/C | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 715246 | Benign: not provided | 113,110,556(+) | G/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv24626 | CNV | loss | 19812545 |
| esv3539690 | CNV | deletion | 23714750 |
| esv3587231 | CNV | loss | 21293372 |
| esv3587232 | CNV | loss | 21293372 |
| esv3894045 | CNV | gain | 25118596 |
| nsv435694 | CNV | deletion | 17901297 |
| nsv437002 | CNV | loss | 16327808 |
| nsv508537 | CNV | deletion | 20534489 |
| nsv999915 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.77;
66.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LRIG2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG2 Gene
Disorders for LRIG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| urofacial syndrome 2 |
|
|
| urofacial syndrome 1 |
|
|
| lagophthalmos |
|
|
| oligodendroglioma |
|
|
| prune belly syndrome |
|
|
Search LRIG2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LRIG2_HUMAN- Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. {ECO:0000269 PubMed:23313374}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for LRIG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for LRIG2 Gene
Publications for LRIG2 Gene
- Characterization and tissue-specific expression of human LRIG2. (PMID: 15145052) Holmlund C … Hedman H (Gene 2004) 3 4 23
- LRIG2 mutations cause urofacial syndrome. (PMID: 23313374) Stuart HM … Newman WG (American journal of human genetics 2013) 3 4
- A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PMID: 20446891) Andersson U … Melin B (Acta oncologica (Stockholm, Sweden) 2010) 3 41
- The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PMID: 15203213) Guo D … Hedman H (Genomics 2004) 3 23
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4
ExternalLinks
Products for LRIG2 Gene
- View all 11 R&D Systems LRIG2 (LRIG2) Products
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- antibodies-online: Show 7 available LRIG2 Antibodies ranked by validation data
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Sources for LRIG2 Gene
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