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Aliases for LRG1 Gene

Aliases for LRG1 Gene

  • Leucine Rich Alpha-2-Glycoprotein 1 2 3 5
  • Leucine Rich Alpha 2 Glycoprotein 2 3
  • LRG 3 4
  • Leucine-Rich Alpha-2-Glycoprotein 3
  • 1300008B03Rik 3
  • 2310031E04Rik 3
  • HMFT1766 3

External Ids for LRG1 Gene

Previous GeneCards Identifiers for LRG1 Gene

  • GC00U914351
  • GC19M004488
  • GC19M004489
  • GC19M004298

Summaries for LRG1 Gene

Entrez Gene Summary for LRG1 Gene

  • The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LRG1 Gene

LRG1 (Leucine Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. Diseases associated with LRG1 include Hydrocephalus and Dependent Personality Disorder. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include transforming growth factor beta receptor binding. An important paralog of this gene is GP1BA.

Gene Wiki entry for LRG1 Gene

Additional gene information for LRG1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRG1 Gene

Genomics for LRG1 Gene

GeneHancer (GH) Regulatory Elements for LRG1 Gene

Promoters and enhancers for LRG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I004539 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.5 -1.5 -1527 6 HDGF FOXA2 MLX ARID4B DMAP1 YY1 POLR2B CBX5 SP5 NFYC LRG1 ENSG00000267385 SH3GL1 ENSG00000267255 PLIN5 CCDC94 KDM4B TICAM1 SEMA6B ZBTB7A
GH19I004538 Enhancer 0.4 Ensembl dbSUPER 550.8 +1.8 1773 0.2 GC19P004539 GC19M004536 LRG1 ENSG00000267385 PLIN5
GH19I004152 Promoter/Enhancer 1.4 EPDnew ENCODE 5.5 +386.6 386636 2.6 FOXA2 PKNOX1 ATF1 YY1 ZNF121 GATA2 FOS RUNX3 RXRA SP5 CREB3L3 CACTIN-AS1 PIAS4 LRG1 MYDGF GC19M004146
GH19I004142 Enhancer 1.5 Ensembl ENCODE dbSUPER 4.8 +393.9 393900 8 PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 CACTIN APBA3 ENSG00000267769 CCDC94 ENSG00000267030 ENSG00000269807 CHAF1A SIRT6 ANKRD24 DPP9-AS1
GH19I004129 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.4 +409.3 409311 2.4 PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A ZNF48 ETS1 TCF12 ZNF121 CREB3L3 ANKRD24 SIRT6 CACTIN-AS1 APBA3 CACTIN EEF2 FSD1 TMIGD2 ENSG00000269807
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRG1 gene promoter:

Genomic Locations for LRG1 Gene

Genomic Locations for LRG1 Gene
4,066 bases
Minus strand

Genomic View for LRG1 Gene

Genes around LRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRG1 Gene

Proteins for LRG1 Gene

  • Protein details for LRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich alpha-2-glycoprotein
    Protein Accession:
    Secondary Accessions:
    • Q8N4F5
    • Q96QZ4

    Protein attributes for LRG1 Gene

    347 amino acids
    Molecular mass:
    38178 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRG1 Gene

Post-translational modifications for LRG1 Gene

  • Glycosylation at isoforms=37, isoforms=79, isoforms=186, posLast=269269, and posLast=325325
  • Modification sites at PhosphoSitePlus

Other Protein References for LRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRG1 Gene

Domains & Families for LRG1 Gene

Gene Families for LRG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRG1: view

No data available for UniProtKB/Swiss-Prot for LRG1 Gene

Function for LRG1 Gene

Gene Ontology (GO) - Molecular Function for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005160 transforming growth factor beta receptor binding IEA --
GO:0005515 protein binding IPI 23868260
genes like me logo Genes that share ontologies with LRG1: view

Phenotypes for LRG1 Gene

genes like me logo Genes that share phenotypes with LRG1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRG1 Gene

Localization for LRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRG1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRG1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005615 extracellular space IEA,IDA 20363744
GO:0016020 membrane NAS 3856868
GO:0035580 specific granule lumen TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with LRG1: view

Pathways & Interactions for LRG1 Gene

genes like me logo Genes that share pathways with LRG1: view

Pathways by source for LRG1 Gene

3 Reactome pathways for LRG1 Gene

Gene Ontology (GO) - Biological Process for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0008150 biological_process ND --
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0045766 positive regulation of angiogenesis IEA --
genes like me logo Genes that share ontologies with LRG1: view

No data available for SIGNOR curated interactions for LRG1 Gene

Drugs & Compounds for LRG1 Gene

(1) Drugs for LRG1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
genes like me logo Genes that share compounds with LRG1: view

Transcripts for LRG1 Gene

mRNA/cDNA for LRG1 Gene

Unigene Clusters for LRG1 Gene

Leucine-rich alpha-2-glycoprotein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRG1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e
SP1: - -
SP2: -
SP3: - -

Relevant External Links for LRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRG1 Gene

This gene is overexpressed in Liver (x35.3) and Whole Blood (x11.8).

Protein differential expression in normal tissues from HIPED for LRG1 Gene

This gene is overexpressed in Urine (19.2), Synovial fluid (11.4), Serum (6.7), and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRG1 Gene

Protein tissue co-expression partners for LRG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRG1 Gene:


SOURCE GeneReport for Unigene cluster for LRG1 Gene:


mRNA Expression by UniProt/SwissProt for LRG1 Gene:

Tissue specificity: Plasma.

Evidence on tissue expression from TISSUES for LRG1 Gene

  • Liver(4.6)
  • Intestine(4.3)
  • Bone marrow(4.2)
  • Kidney(4.2)
  • Lung(4.2)
  • Nervous system(4.2)
  • Saliva(4)
  • Blood(2)
genes like me logo Genes that share expression patterns with LRG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRG1 Gene

Orthologs for LRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRG1 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia LRG1 33 34
  • 78.96 (n)
(Bos Taurus)
Mammalia LRG1 33 34
  • 76.88 (n)
(Mus musculus)
Mammalia Lrg1 33 16 34
  • 69.35 (n)
(Rattus norvegicus)
Mammalia Lrg1 33
  • 67.65 (n)
(Monodelphis domestica)
Mammalia LRG1 34
  • 48 (a)
(Gallus gallus)
Aves LOC100858066 33
  • 52.45 (n)
LRG1 34
  • 40 (a)
(Anolis carolinensis)
Reptilia LRG1 34
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrg1 33
  • 44.09 (n)
(Danio rerio)
Actinopterygii si:dkey-90m5.4 33
  • 45.69 (n)
LRG1 34
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16974 34
  • 8 (a)
Species where no ortholog for LRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRG1 Gene

Gene Tree for LRG1 (if available)
Gene Tree for LRG1 (if available)

Paralogs for LRG1 Gene

Paralogs for LRG1 Gene

(2) SIMAP similar genes for LRG1 Gene using alignment to 1 proteins: Pseudogenes for LRG1 Gene

genes like me logo Genes that share paralogs with LRG1: view

Variants for LRG1 Gene

Sequence variations from dbSNP and Humsavar for LRG1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000218377 -- 4,537,692(-) C/T 3_prime_UTR_variant
rs1001437264 -- 4,540,127(-) T/A upstream_transcript_variant
rs1002368841 -- 4,541,580(-) G/C upstream_transcript_variant
rs1002864890 -- 4,541,100(-) G/C/T upstream_transcript_variant
rs1002906648 -- 4,541,829(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRG1 Gene

Variant ID Type Subtype PubMed ID
nsv428361 CNV loss 18775914
nsv578444 CNV gain 21841781
nsv833720 CNV loss 17160897

Variation tolerance for LRG1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRG1 Gene

Disorders for LRG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • hydrocephalus, nonsyndromic, autosomal recessive 1
dependent personality disorder
cecal disease
  • disorder of cecum
- elite association - COSMIC cancer census association via MalaCards
Search LRG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LRG1

genes like me logo Genes that share disorders with LRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRG1 Gene

Publications for LRG1 Gene

  1. Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation. (PMID: 12223515) O'Donnell LC … Avalos BR (Journal of leukocyte biology 2002) 2 3 4 58
  2. Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. (PMID: 3856868) Takahashi N … Putnam FW (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4 58
  3. Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1. (PMID: 19851871) Codina R … Jemmerson R (Apoptosis : an international journal on programmed cell death 2010) 3 22 58
  4. Specific isoforms of leucine-rich alpha2-glycoprotein detected in the proliferative endometrium of women undergoing assisted reproduction are associated with spontaneous pregnancy. (PMID: 17583700) Gillott DJ … Grudzinskas JG (Fertility and sterility 2008) 3 22 58
  5. Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus. (PMID: 17194537) Li X … Arai H (Neuroscience letters 2007) 3 22 58

Products for LRG1 Gene

Sources for LRG1 Gene

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