The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008] See more...

Aliases for LRG1 Gene

Aliases for LRG1 Gene

  • Leucine Rich Alpha-2-Glycoprotein 1 2 3 5
  • Leucine-Rich Alpha-2-Glycoprotein 3 4
  • Leucine Rich Alpha 2 Glycoprotein 2 3
  • LRG 3 4
  • 1300008B03Rik 3
  • 2310031E04Rik 3
  • HMFT1766 3

External Ids for LRG1 Gene

Previous GeneCards Identifiers for LRG1 Gene

  • GC00U914351
  • GC19M004488
  • GC19M004489
  • GC19M004298

Summaries for LRG1 Gene

Entrez Gene Summary for LRG1 Gene

  • The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LRG1 Gene

LRG1 (Leucine Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. Diseases associated with LRG1 include Appendicitis and Normal Pressure Hydrocephalus. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include transforming growth factor beta receptor binding. An important paralog of this gene is LRIG1.

Gene Wiki entry for LRG1 Gene

Additional gene information for LRG1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRG1 Gene

Genomics for LRG1 Gene

GeneHancer (GH) Regulatory Elements for LRG1 Gene

Promoters and enhancers for LRG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004539 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 509.4 -0.4 -447 2.8 POLR2G GTF2E2 POLR2A RELA TOE1 TGIF2 CTBP1 TRIM25 TEAD1 HINFP PLIN5 LRG1 ENSG00000267385 HSALNG0123395 KDM4B TICAM1 SEMA6B ZBTB7A YJU2 lnc-HDGFL2-5
GH19J004540 Enhancer 0.6 dbSUPER 500.7 +1.8 1828 0.9 NFIC ZNF223 CTCF RAD21 ZBTB33 L3MBTL2 MAX AGO1 THAP1 EGR1 ENSG00000267385 LRG1 lnc-HDGFL2-4
GH19J004538 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.7 +1.1 1140 0.1 ENSG00000267385 LRG1 HSALNG0123395 lnc-HDGFL2-4
GH19J004152 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 5.5 +386.2 386198 2.6 POLR2G SP1 NCOR1 KDM6A FOS ZNF623 RUNX1 CTBP1 SKI NFYB CREB3L3 LRG1 MYDGF RF00017-2752
GH19J004142 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.7 +393.3 393338 8.2 EP300 FOXK2 TCF12 NCOR1 BCLAF1 RBAK PHB2 KDM6A ZNF263 TCF7 ANKRD24 SIRT6 MAP2K2 FSD1 TMIGD2 CREB3L3 LRG1 ENSG00000278007
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRG1

Top Transcription factor binding sites by QIAGEN in the LRG1 gene promoter:
  • AP-2beta
  • AP-2gamma
  • MRF-2
  • NF-1
  • p300
  • Pax-5
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for LRG1 Gene

Genomic Locations for LRG1 Gene
chr19:4,536,402-4,540,036
(GRCh38/hg38)
Size:
3,635 bases
Orientation:
Minus strand
chr19:4,536,421-4,540,486
(GRCh37/hg19)
Size:
4,066 bases
Orientation:
Minus strand

Genomic View for LRG1 Gene

Genes around LRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRG1 Gene

Proteins for LRG1 Gene

  • Protein details for LRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02750-A2GL_HUMAN
    Recommended name:
    Leucine-rich alpha-2-glycoprotein
    Protein Accession:
    P02750
    Secondary Accessions:
    • Q8N4F5
    • Q96QZ4

    Protein attributes for LRG1 Gene

    Size:
    347 amino acids
    Molecular mass:
    38178 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRG1 Gene

Post-translational modifications for LRG1 Gene

  • Glycosylation at Thr37, Asn79, Asn186, Asn269, and Asn325
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • A2GL_HUMAN (676)

Other Protein References for LRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRG1 Gene

Domains & Families for LRG1 Gene

Gene Families for LRG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for LRG1 Gene

Blocks:
  • Cysteine-rich flanking region, C-terminal
  • Leucine-rich repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRG1 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich alpha-2-glycoprotein (A2GL_HUMAN)
  • cDNA FLJ54228, highly similar to Leucine-rich alpha-2-glycoprotein (B4E1I8_HUMAN)
  • cDNA, FLJ95324, highly similar to Homo sapiens leucine-rich alpha-2-glycoprotein 1 (LRG1), mRNA (Q68CK4_HUMAN)
genes like me logo Genes that share domains with LRG1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRG1 Gene

Function for LRG1 Gene

Phenotypes From GWAS Catalog for LRG1 Gene

Gene Ontology (GO) - Molecular Function for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005160 transforming growth factor beta receptor binding IEA --
GO:0005515 protein binding IPI,IEA 23868260
genes like me logo Genes that share ontologies with LRG1: view
genes like me logo Genes that share phenotypes with LRG1: view

Animal Models for LRG1 Gene

MGI Knock Outs for LRG1:
  • Lrg1 Lrg1<tm1.1Tnaka>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRG1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRG1 Gene

Localization for LRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRG1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,HDA --
GO:0005615 extracellular space IEA,IDA 20363744
GO:0016020 membrane NAS 3856868
GO:0035580 specific granule lumen TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with LRG1: view

Pathways & Interactions for LRG1 Gene

PathCards logo

SuperPathways for LRG1 Gene

genes like me logo Genes that share pathways with LRG1: view

Pathways by source for LRG1 Gene

3 Reactome pathways for LRG1 Gene

Gene Ontology (GO) - Biological Process for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0008150 biological_process ND --
GO:0009617 response to bacterium IEA --
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with LRG1: view

No data available for SIGNOR curated interactions for LRG1 Gene

Drugs & Compounds for LRG1 Gene

(1) Drugs for LRG1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 236
genes like me logo Genes that share compounds with LRG1: view

Transcripts for LRG1 Gene

mRNA/cDNA for LRG1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRG1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRG1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e
SP1: - -
SP2: -
SP3: - -

Relevant External Links for LRG1 Gene

GeneLoc Exon Structure for
LRG1

Expression for LRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRG1 Gene

This gene is overexpressed in Liver (x35.3) and Whole Blood (x11.8).

Protein differential expression in normal tissues from HIPED for LRG1 Gene

This gene is overexpressed in Urine (19.2), Synovial fluid (11.4), Serum (6.7), and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRG1 Gene



Protein tissue co-expression partners for LRG1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRG1

SOURCE GeneReport for Unigene cluster for LRG1 Gene:

Hs.655559

mRNA Expression by UniProt/SwissProt for LRG1 Gene:

P02750-A2GL_HUMAN
Tissue specificity: Plasma.

Evidence on tissue expression from TISSUES for LRG1 Gene

  • Liver(4.6)
  • Intestine(4.3)
  • Bone marrow(4.2)
  • Kidney(4.2)
  • Lung(4.2)
  • Nervous system(4.2)
  • Saliva(4)
  • Blood(2)
genes like me logo Genes that share expression patterns with LRG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRG1 Gene

Orthologs for LRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRG1 31 30
  • 99.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRG1 31 30
  • 78.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRG1 31 30
  • 76.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrg1 17 31 30
  • 69.35 (n)
rat
(Rattus norvegicus)
Mammalia Lrg1 30
  • 67.65 (n)
oppossum
(Monodelphis domestica)
Mammalia LRG1 31
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858066 30
  • 52.45 (n)
LRG1 31
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRG1 31
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrg1 30
  • 44.09 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-90m5.4 30
  • 45.69 (n)
LRG1 31
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16974 31
  • 8 (a)
OneToMany
Species where no ortholog for LRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRG1 Gene

ENSEMBL:
Gene Tree for LRG1 (if available)
TreeFam:
Gene Tree for LRG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRG1: view image

Paralogs for LRG1 Gene

(2) SIMAP similar genes for LRG1 Gene using alignment to 1 proteins:

  • A2GL_HUMAN

Pseudogenes.org Pseudogenes for LRG1 Gene

genes like me logo Genes that share paralogs with LRG1: view

Variants for LRG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRG1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs7251081 - p.Gly64Ser
rs966384 - p.Pro133Ser

Additional dbSNP identifiers (rs#s) for LRG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRG1 Gene

Variant ID Type Subtype PubMed ID
nsv428361 CNV loss 18775914
nsv578444 CNV gain 21841781
nsv833720 CNV loss 17160897

Variation tolerance for LRG1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRG1 Gene

Disorders for LRG1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for LRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
appendicitis
  • acute appendicitis
normal pressure hydrocephalus
  • low pressure hydrocephalus
cecal disease
  • disorder of cecum
communicating hydrocephalus
hydrocephalus
  • hydrocephalus, nonsyndromic, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
Search LRG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LRG1

genes like me logo Genes that share disorders with LRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRG1 Gene

Publications for LRG1 Gene

  1. Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation. (PMID: 12223515) O'Donnell LC … Avalos BR (Journal of leukocyte biology 2002) 2 3 4 54
  2. Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. (PMID: 3856868) Takahashi N … Putnam FW (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4 54
  3. Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1. (PMID: 19851871) Codina R … Jemmerson R (Apoptosis : an international journal on programmed cell death 2010) 3 23 54
  4. Specific isoforms of leucine-rich alpha2-glycoprotein detected in the proliferative endometrium of women undergoing assisted reproduction are associated with spontaneous pregnancy. (PMID: 17583700) Gillott DJ … Grudzinskas JG (Fertility and sterility 2008) 3 23 54
  5. Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus. (PMID: 17194537) Li X … Arai H (Neuroscience letters 2007) 3 23 54

Products for LRG1 Gene

Sources for LRG1 Gene