Aliases for LRCH3 Gene

Aliases for LRCH3 Gene

  • Leucine Rich Repeats And Calponin Homology Domain Containing 3 2 3 5
  • Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 3 3 4
  • Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 3 2 3
  • DISP Complex Protein LRCH3 3 4
  • MGC4126 2
  • LRCH3 5

External Ids for LRCH3 Gene

Previous GeneCards Identifiers for LRCH3 Gene

  • GC03P198845
  • GC03P199006
  • GC03P197518
  • GC03P194821

Summaries for LRCH3 Gene

GeneCards Summary for LRCH3 Gene

LRCH3 (Leucine Rich Repeats And Calponin Homology Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is LRCH1.

UniProtKB/Swiss-Prot Summary for LRCH3 Gene

  • As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LRCH3 Gene

Genomics for LRCH3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for LRCH3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRCH3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LRCH3

Top Transcription factor binding sites by QIAGEN in the LRCH3 gene promoter:
  • AML1a
  • c-Myb
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • HSF2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-4a

Genomic Locations for LRCH3 Gene

Latest Assembly
chr3:197,791,226-197,889,494
(GRCh38/hg38)
Size:
98,269 bases
Orientation:
Plus strand

Previous Assembly
chr3:197,518,097-197,615,307
(GRCh37/hg19 by Entrez Gene)
Size:
97,211 bases
Orientation:
Plus strand

chr3:197,518,097-197,615,307
(GRCh37/hg19 by Ensembl)
Size:
97,211 bases
Orientation:
Plus strand

Genomic View for LRCH3 Gene

Genes around LRCH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRCH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRCH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRCH3 Gene

Proteins for LRCH3 Gene

  • Protein details for LRCH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96II8-LRCH3_HUMAN
    Recommended name:
    DISP complex protein LRCH3
    Protein Accession:
    Q96II8
    Secondary Accessions:
    • B4E0T7
    • Q96FP9
    • Q9NT52

    Protein attributes for LRCH3 Gene

    Size:
    777 amino acids
    Molecular mass:
    86083 Da
    Quaternary structure:
    • Component of the DOCK7-induced septin displacement/DISP complex, at least composed of DOCK7, LRCH3 and MYO6.

    Alternative splice isoforms for LRCH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRCH3 Gene

Post-translational modifications for LRCH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRCH3 Gene

Domains & Families for LRCH3 Gene

Gene Families for LRCH3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for LRCH3 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
  • Calponin-like actin-binding

Suggested Antigen Peptide Sequences for LRCH3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61518, highly similar to Homo sapiens leucine-rich repeats and calponin homology (CH) domain containing 3 (LRCH3), mRNA (B4E0T7_HUMAN)
  • Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3_HUMAN)
genes like me logo Genes that share domains with LRCH3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for LRCH3 Gene

Function for LRCH3 Gene

Molecular function for LRCH3 Gene

UniProtKB/Swiss-Prot Function:
As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.

Phenotypes From GWAS Catalog for LRCH3 Gene

Gene Ontology (GO) - Molecular Function for LRCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with LRCH3: view
genes like me logo Genes that share phenotypes with LRCH3: view

miRNA for LRCH3 Gene

miRTarBase miRNAs that target LRCH3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRCH3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRCH3 Gene

Localization for LRCH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRCH3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRCH3 gene
Compartment Confidence
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endosome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IC 29467281
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with LRCH3: view

Pathways & Interactions for LRCH3 Gene

PathCards logo

SuperPathways for LRCH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRCH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032185 septin cytoskeleton organization IMP 29467281
genes like me logo Genes that share ontologies with LRCH3: view

No data available for Pathways by source and SIGNOR curated interactions for LRCH3 Gene

Drugs & Compounds for LRCH3 Gene

No Compound Related Data Available

Transcripts for LRCH3 Gene

mRNA/cDNA for LRCH3 Gene

7 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LRCH3

Alternative Splicing Database (ASD) splice patterns (SP) for LRCH3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:

Relevant External Links for LRCH3 Gene

GeneLoc Exon Structure for
LRCH3

Expression for LRCH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRCH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRCH3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.6) and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRCH3 Gene



Protein tissue co-expression partners for LRCH3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LRCH3

SOURCE GeneReport for Unigene cluster for LRCH3 Gene:

Hs.518414

Evidence on tissue expression from TISSUES for LRCH3 Gene

  • Nervous system(4.7)
  • Muscle(4.3)
  • Liver(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with LRCH3: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRCH3 Gene

Orthologs for LRCH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRCH3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LRCH3 29 30
  • 99.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LRCH3 29 30
  • 90.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LRCH3 29 30
  • 87.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lrch3 29 16 30
  • 86.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lrch3 29
  • 85.69 (n)
Oppossum
(Monodelphis domestica)
Mammalia LRCH3 30
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LRCH3 30
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LRCH3 29 30
  • 75.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 90 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489676 29
  • 65.19 (n)
Zebrafish
(Danio rerio)
Actinopterygii LRCH3 30
  • 68 (a)
OneToOne
zgc:171915 29
  • 64.05 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5073 29
Species where no ortholog for LRCH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for LRCH3 Gene

ENSEMBL:
Gene Tree for LRCH3 (if available)
TreeFam:
Gene Tree for LRCH3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRCH3: view image
Alliance of Genome Resources:
Additional Orthologs for LRCH3

Paralogs for LRCH3 Gene

(8) SIMAP similar genes for LRCH3 Gene using alignment to 8 proteins:

  • LRCH3_HUMAN
  • B4E0T7_HUMAN
  • E9PD99_HUMAN
  • F5H3V2_HUMAN
  • F8WFB5_HUMAN
  • H7C0F9_HUMAN
  • H7C0J8_HUMAN
  • H7C1G3_HUMAN
genes like me logo Genes that share paralogs with LRCH3: view

Variants for LRCH3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LRCH3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs36078463 -- p.Pro522Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for LRCH3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for LRCH3 Gene

Variant ID Type Subtype PubMed ID
dgv5044n100 CNV gain 25217958
dgv5045n100 CNV gain 25217958
dgv8865n54 CNV gain 21841781
dgv912e199 CNV deletion 23128226
esv2049335 CNV deletion 18987734
esv2605459 CNV deletion 19546169
esv2661799 CNV deletion 23128226
esv2667470 CNV deletion 23128226
esv2751989 CNV gain 17911159
esv2763718 CNV gain+loss 21179565
esv3569234 CNV loss 25503493
esv3569235 CNV loss 25503493
esv3575647 CNV gain 25503493
esv3599319 CNV gain 21293372
esv3599322 CNV gain 21293372
esv3599323 CNV gain 21293372
esv3599324 CNV gain 21293372
esv3599326 CNV loss 21293372
esv3599327 CNV loss 21293372
nsv1001319 CNV loss 25217958
nsv1011831 CNV gain 25217958
nsv1161021 CNV duplication 26073780
nsv1161022 CNV deletion 26073780
nsv519682 CNV loss 19592680
nsv527527 CNV gain 19592680
nsv829832 CNV loss 17160897
nsv963400 CNV duplication 23825009
nsv999711 CNV gain 25217958

Variation tolerance for LRCH3 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRCH3 Gene

Human Gene Mutation Database (HGMD)
LRCH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRCH3
Leiden Open Variation Database (LOVD)
LRCH3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRCH3 Gene

Disorders for LRCH3 Gene

Additional Disease Information for LRCH3

No disorders were found for LRCH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRCH3 Gene

Publications for LRCH3 Gene

  1. The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics. (PMID: 29467281) O'Loughlin T … Buss F (EMBO reports 2018) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3

Products for LRCH3 Gene

Sources for LRCH3 Gene