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Aliases for LRCH2 Gene

Aliases for LRCH2 Gene

  • Leucine Rich Repeats And Calponin Homology Domain Containing 2 2 3 5
  • Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 2 2 3
  • Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 2 3
  • DA204F4.4 3
  • KIAA1495 4

External Ids for LRCH2 Gene

Previous GeneCards Identifiers for LRCH2 Gene

  • GC0XM113110
  • GC0XM114168
  • GC0XM114251
  • GC0XM114345
  • GC0XM103930

Summaries for LRCH2 Gene

Entrez Gene Summary for LRCH2 Gene

  • This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for LRCH2 Gene

LRCH2 (Leucine Rich Repeats And Calponin Homology Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is LRCH1.

Additional gene information for LRCH2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRCH2 Gene

Genomics for LRCH2 Gene

GeneHancer (GH) Regulatory Elements for LRCH2 Gene

Promoters and enhancers for LRCH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI115233 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 565.6 +0.3 274 1.6 PKNOX1 SIN3A ZNF664 ZFHX2 RBAK ZNF366 POLR2A PATZ1 PRDM10 ZNF600 LRCH2 API5P1 GC0XP115199
GH0XI115559 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.3 -327.9 -327944 5.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 YY1 GLIS2 ZNF213 FOS PLS3 PLS3-AS1 LRCH2 API5P1
GH0XI115344 Enhancer 1.1 Ensembl ENCODE 11.4 -111.2 -111234 2.3 PKNOX1 FOXA2 NFIB ARID4B SIN3A DMAP1 ZNF48 RAD21 RARA ETS1 LRCH2 LUZP4 LOC100129818
GH0XI115958 Enhancer 0.7 ENCODE 12.6 -724.6 -724648 0.6 CTCF ZSCAN26 ZNF384 RAD21 ZNF121 CTBP1 GATA3 PATZ1 ZNF444 CHD2 LRCH2 DANT2 DANT1
GH0XI115959 Enhancer 0.6 ENCODE 12.6 -725.1 -725128 0.2 CTCF ZNF654 ZSCAN26 RAD21 CTBP1 ZFHX2 IKZF1 EGR2 LRCH2 DANT2 DANT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRCH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRCH2 gene promoter:

Genomic Locations for LRCH2 Gene

Genomic Locations for LRCH2 Gene
123,460 bases
Minus strand

Genomic View for LRCH2 Gene

Genes around LRCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRCH2 Gene

Proteins for LRCH2 Gene

  • Protein details for LRCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat and calponin homology domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • F5H2T1
    • Q08AD5
    • Q9HA88
    • Q9P233

    Protein attributes for LRCH2 Gene

    765 amino acids
    Molecular mass:
    84588 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA96019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70721.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42077.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI43033.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRCH2 Gene


neXtProt entry for LRCH2 Gene

Post-translational modifications for LRCH2 Gene

No Post-translational modifications

Other Protein References for LRCH2 Gene

No data available for DME Specific Peptides for LRCH2 Gene

Domains & Families for LRCH2 Gene

Gene Families for LRCH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LRCH2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRCH2: view

No data available for UniProtKB/Swiss-Prot for LRCH2 Gene

Function for LRCH2 Gene

genes like me logo Genes that share phenotypes with LRCH2: view

Animal Model Products

miRNA for LRCH2 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRCH2 Gene

Localization for LRCH2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRCH2 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with LRCH2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRCH2 Gene

Pathways & Interactions for LRCH2 Gene

SuperPathways for LRCH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with LRCH2: view

No data available for Pathways by source and SIGNOR curated interactions for LRCH2 Gene

Drugs & Compounds for LRCH2 Gene

No Compound Related Data Available

Transcripts for LRCH2 Gene

Unigene Clusters for LRCH2 Gene

Leucine-rich repeats and calponin homology (CH) domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRCH2 Gene

No ASD Table

Relevant External Links for LRCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRCH2 Gene

Protein differential expression in normal tissues from HIPED for LRCH2 Gene

This gene is overexpressed in Frontal cortex (33.5) and Adrenal (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRCH2 Gene

Protein tissue co-expression partners for LRCH2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRCH2 Gene:


SOURCE GeneReport for Unigene cluster for LRCH2 Gene:


Evidence on tissue expression from TISSUES for LRCH2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with LRCH2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRCH2 Gene

Orthologs for LRCH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRCH2 33 34
  • 96.75 (n)
(Canis familiaris)
Mammalia LRCH2 33 34
  • 94.82 (n)
(Bos Taurus)
Mammalia LRCH2 33
  • 94.04 (n)
(Rattus norvegicus)
Mammalia Lrch2 33
  • 90.64 (n)
(Mus musculus)
Mammalia Lrch2 33 16 34
  • 90.56 (n)
(Monodelphis domestica)
Mammalia LRCH2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia LRCH2 34
  • 68 (a)
(Gallus gallus)
Aves LRCH2 33 34
  • 80.3 (n)
(Anolis carolinensis)
Reptilia LRCH2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrch2 33
  • 74.11 (n)
Str.4233 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33837 33
(Danio rerio)
Actinopterygii lrch2 34
  • 66 (a)
LOC101882684 33
  • 65.87 (n)
Species where no ortholog for LRCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRCH2 Gene

Gene Tree for LRCH2 (if available)
Gene Tree for LRCH2 (if available)

Paralogs for LRCH2 Gene

(4) SIMAP similar genes for LRCH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRCH2: view

Variants for LRCH2 Gene

Sequence variations from dbSNP and Humsavar for LRCH2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000113932 -- 115,116,945(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000164860 -- 115,159,881(-) A/G intron_variant
rs1000193794 -- 115,174,504(-) T/C intron_variant
rs1000274183 -- 115,174,261(-) G/A intron_variant
rs1000287337 -- 115,231,626(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRCH2 Gene

Variant ID Type Subtype PubMed ID
nsv520351 CNV gain 19592680
nsv516624 CNV gain 19592680
nsv513764 CNV insertion 21212237
nsv511667 CNV gain 21212237
nsv1153779 CNV duplication 26484159
nsv1118067 CNV deletion 24896259
nsv1075738 CNV deletion 25765185
esv3577051 CNV gain 25503493
esv3577049 CNV gain 25503493
esv3452048 CNV insertion 20981092
esv33994 CNV gain+loss 17666407
esv1448157 CNV deletion 17803354

Variation tolerance for LRCH2 Gene

Gene Damage Index Score: 1.23; 24.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRCH2 Gene

Disorders for LRCH2 Gene

Additional Disease Information for LRCH2

No disorders were found for LRCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRCH2 Gene

Publications for LRCH2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for LRCH2 Gene

Sources for LRCH2 Gene

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