Aliases for LRCH1 Gene
External Ids for LRCH1 Gene
Previous HGNC Symbols for LRCH1 Gene
Previous GeneCards Identifiers for LRCH1 Gene
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]
GeneCards Summary for LRCH1 Gene
UniProtKB/Swiss-Prot Summary for LRCH1 Gene
Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.