Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
LPO (Lactoperoxidase) is a Protein Coding gene. Diseases associated with LPO include Aplasia Of Lacrimal And Salivary Glands and Peroxidase, Salivary. Among its related pathways are Salivary secretion. Gene Ontology (GO) annotations related to this gene include heme binding and thiocyanate peroxidase activity. An important paralog of this gene is MPO.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J058218 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.8 | 827 | 2 | ARHGAP35 CREB1 GATAD2A CTCF YBX1 PRDM10 TFE3 RFX1 IKZF1 NFKBIZ | MKS1 ENSG00000287337 LOC105371841 LPO SRSF1 TEX14 | |
GH17J058238 | Promoter | 1 | EPDnew Ensembl | 600.4 | +20.2 | 20153 | 0.2 | ATF7 CEBPG ATF4 CEBPB ATF3 | LPO ENSG00000286788 MKS1 MPO | |
GH17J058242 | Promoter | 0.3 | EPDnew | 600.4 | +23.6 | 23578 | 0.1 | LPO ENSG00000286788 MKS1 MPO | ||
GH17J058252 | Promoter | 0.3 | EPDnew | 600.3 | +33.6 | 33602 | 0.1 | LPO MKS1 EPX ENSG00000286788 MPO lnc-TSPOAP1-3 | ||
GH17J058217 | Enhancer | 0.2 | ENCODE | 600.7 | -0.6 | -623 | 0.1 | ENSG00000287337 LOC105371841 LPO MKS1 lnc-MPO-3 EPX |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | IBA | 21873635 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
GO:0036393 | thiocyanate peroxidase activity | IBA,IDA | 12626341 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 24248522 |
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IBA,IEA | -- |
GO:0016323 | basolateral plasma membrane | IDA | 19059195 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Salivary secretion |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 24248522 |
GO:0006979 | response to oxidative stress | NAS | 8964511 |
GO:0018969 | thiocyanate metabolic process | IEA | -- |
GO:0042742 | defense response to bacterium | IDA | 12626341 |
GO:0042744 | hydrogen peroxide catabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Hypothiocyanite |
|
63296-34-4 | ||||
2-Phenylacetamide |
|
103-81-1 |
|
|||
methanol |
|
67-56-1 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LPO 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LPO 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LPO 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lpo 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Lpo 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LPO 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | LPO 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | mpx 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10211 32 |
|
|
|
CG6879 32 |
|
|
|||
Pxd 32 |
|
|
|||
CG6969 32 |
|
|
|||
pxt 32 |
|
|
|||
CG5873 31 32 |
|
ManyToMany | |||
CG8913 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | ZK430.8 32 |
|
|
|
C46A5.4 32 |
|
|
|||
K10B4.1 32 |
|
|
|||
F09F3.5 32 |
|
|
|||
R08F11.7 31 32 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712294 | Benign: not provided | 58,254,827(+) | A/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
770270 | Benign: not provided | 58,244,090(+) | G/C | INTRON_VARIANT | |
781308 | Benign: not provided | 58,267,596(+) | T/C | INTRON_VARIANT | |
781371 | Benign: not provided | 58,243,009(+) | C/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
781372 | Benign: not provided | 58,247,627(+) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
aplasia of lacrimal and salivary glands |
|
|
peroxidase, salivary |
|
|
gingivitis |
|
|
mastitis |
|
|
common cold |
|
|