Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
LPO (Lactoperoxidase) is a Protein Coding gene. Diseases associated with LPO include Waardenburg Syndrome, Type 2D and Dental Caries. Among its related pathways are Salivary secretion. Gene Ontology (GO) annotations related to this gene include heme binding and thiocyanate peroxidase activity. An important paralog of this gene is MPO.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J058218 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 750.6 | +0.8 | 827 | 2 | ZNF785 ZBTB40 CTCF RBPJ POLR2A ATF1 CREB1 HCFC1 MIXL1 RUNX1 | MKS1 ENSG00000287337 LOC105371841 LPO HSALNG0117695 SRSF1 VEZF1 SKA2 SMG8 TEX14 | |
GH17J058238 | Promoter | 0.8 | EPDnew Ensembl | 750.3 | +20.2 | 20153 | 0.2 | CEBPG CEBPB | LPO ENSG00000286788 LOC105371841 | |
GH17J058242 | Promoter | 0.3 | EPDnew | 750.3 | +23.6 | 23578 | 0.1 | LPO ENSG00000286788 LOC105371841 | ||
GH17J058252 | Promoter | 0.3 | EPDnew | 750.3 | +33.6 | 33602 | 0.1 | LPO MKS1 EPX HSALNG0117698 lnc-TSPOAP1-3 | ||
GH17J058217 | Enhancer | 0.2 | ENCODE | 750.6 | -0.6 | -623 | 0.1 | ENSG00000287337 LPO HSALNG0117695 MKS1 lnc-MPO-3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | IBA | 21873635 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
GO:0036393 | thiocyanate peroxidase activity | IBA,IDA | 12626341 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 24248522 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0016323 | basolateral plasma membrane | IDA | 19059195 |
GO:0070062 | extracellular exosome | HDA | 19199708 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Salivary secretion |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 24248522 |
GO:0006979 | response to oxidative stress | NAS | 8964511 |
GO:0018969 | thiocyanate metabolic process | IEA | -- |
GO:0042742 | defense response to bacterium | IDA | 12626341 |
GO:0042744 | hydrogen peroxide catabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Hypothiocyanite |
|
63296-34-4 | ||||
2-Phenylacetamide |
|
103-81-1 |
|
|||
methanol |
|
67-56-1 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LPO 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | LPO 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | LPO 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Lpo 32 |
|
||
mouse (Mus musculus) |
Mammalia | Lpo 17 33 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | LPO 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | LPO 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | -- 33 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
zebrafish (Danio rerio) |
Actinopterygii | mpx 33 |
|
OneToMany | |
fruit fly (Drosophila melanogaster) |
Insecta | CG10211 34 |
|
|
|
CG6879 34 |
|
|
|||
Pxd 34 |
|
|
|||
CG6969 34 |
|
|
|||
pxt 34 |
|
|
|||
CG5873 33 34 |
|
ManyToMany | |||
CG8913 34 |
|
|
|||
worm (Caenorhabditis elegans) |
Secernentea | ZK430.8 34 |
|
|
|
C46A5.4 34 |
|
|
|||
K10B4.1 34 |
|
|
|||
F09F3.5 34 |
|
|
|||
R08F11.7 33 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs67390833 | benign, not specified | 58,244,091(+) | ACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACAC/ACACACACACACACACACACACAC/ACACACACACACACACACACACACAC/ACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACACACACACACAC | genic_upstream_transcript_variant, intron_variant | |
rs1000156234 | -- | 58,238,663(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant | |
rs1000159089 | -- | 58,268,652(+) | A/G | downstream_transcript_variant | |
rs1000306544 | -- | 58,254,412(+) | T/C | intron_variant | |
rs1000358578 | -- | 58,254,121(+) | AGA/AGAAAGA | intron_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
waardenburg syndrome, type 2d |
|
|
dental caries |
|
|
aplasia of lacrimal and salivary glands |
|
|
cystic fibrosis |
|
|
asthma |
|