Aliases for LPO Gene
External Ids for LPO Gene
- HGNC: 6678
- Entrez Gene: 4025
- Ensembl: ENSG00000167419
- OMIM: 150205
- UniProtKB: P22079
Previous GeneCards Identifiers for LPO Gene
- GC17P056060
- GC17P058797
- GC17P056658
- GC17P056790
- GC17P053670
- GC17P056315
- GC17P051676
Summaries for LPO Gene
-
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for LPO Gene
LPO (Lactoperoxidase) is a Protein Coding gene. Diseases associated with LPO include Dental Caries and Aplasia Of Lacrimal And Salivary Glands. Among its related pathways are Salivary secretion. Gene Ontology (GO) annotations related to this gene include heme binding and thiocyanate peroxidase activity. An important paralog of this gene is MPO.
UniProtKB/Swiss-Prot for LPO Gene
-
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.
Additional gene information for LPO Gene
- Monarch Initiative
- Search for LPO at DataMed
- Search for LPO at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPO Gene
Genomics for LPO Gene
GeneHancer (GH) Regulatory Elements for LPO Gene
Promoters and enhancers for LPO Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J058218 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 650.7 | +0.8 | 827 | 1.9 | HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A YBX1 DMAP1 | MKS1 LOC105371841 LPO TEX14 | |
| GH17J058238 | Promoter | 0.7 | EPDnew | 650.3 | +20.1 | 20134 | 0.1 | ATF4 CEBPB CEBPG | LPO LOC105371841 MPO | |
| GH17J058242 | Promoter | 0.5 | EPDnew | 650.3 | +23.6 | 23578 | 0.1 | LPO LOC105371841 MPO | ||
| GH17J058252 | Promoter | 0.5 | EPDnew | 650.3 | +33.6 | 33602 | 0.1 | LPO MKS1 EPX MPO LOC105371841 | ||
| GH17J058217 | Enhancer | 0.2 | ENCODE | 650.7 | -0.6 | -623 | 0.1 | LPO MKS1 ENSG00000278627 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around LPO on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the LPO gene promoter:
-
- STAT3
- IRF-1
- NF-kappaB1
- NF-kappaB
- p53
- RelA
- AREB6
- Lmo2
Regulatory Element Products
Genomic Locations for LPO Gene
Genomic Locations for LPO Gene
- chr17:58,218,548-58,268,536
- (GRCh38/hg38)
- Size:
- 49,989 bases
- Orientation:
- Plus strand
- chr17:56,295,909-56,345,879
- (GRCh37/hg19)
- Size:
- 49,971 bases
- Orientation:
- Plus strand
Genomic View for LPO Gene
Genes around LPO on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by Entrez Gene
- 17q22 by HGNC
- 17q22 by Ensembl
LPO Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LPO Gene
Proteins for LPO Gene
-
Protein details for LPO Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22079-PERL_HUMAN
- Recommended name:
- Lactoperoxidase
- Protein Accession:
- P22079
- A5JUY4
- E7EMJ3
- Q13408
- Q3KNQ2
Protein attributes for LPO Gene
- Size:
- 712 amino acids
- Molecular mass:
- 80288 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cofactor:
- Name=heme b; Xref=ChEBI:CHEBI:60344;
- Quaternary structure:
- No Data Available
Protein Expression for LPO Gene
Post-translational modifications for LPO Gene
Other Protein References for LPO Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LPO
- Invitrogen Antibodies for LPO (AFLGC-LPO)
- GeneTex LPO Antibody for LPO
Protein Products
-
OriGene Purified Proteins for LPO
- Search Origene for MassSpec and Protein Over-expression Lysates for LPO
- Origene Custom Protein Services for LPO
- Search GeneTex for Proteins for LPO
Assay Products
No data available for DME Specific Peptides for LPO Gene
Domains & Families for LPO Gene
Gene Families for LPO Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for LPO Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LPO Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P22079- Family:
-
- Belongs to the peroxidase family. XPO subfamily.
Function for LPO Gene
Molecular function for LPO Gene
- UniProtKB/Swiss-Prot Function:
- Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
Enzyme Numbers (IUBMB) for LPO Gene
Phenotypes From GWAS Catalog for LPO Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004601 | peroxidase activity | IEA,IBA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0020037 | heme binding | IEA | -- |
| GO:0036393 | thiocyanate peroxidase activity | IDA | 12626341 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for LPO Gene
- MGI mutant phenotypes for LPO:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for LPO:
Animal Models for LPO Gene
- MGI Knock Outs for LPO:
-
- Lpo Lpo<tm1b(EUCOMM)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for LPO
- Cyagen custom Knockout/knockin (KOKI) mouse models for LPO
-
CRISPR Products
-
OriGene CRISPR knockouts for LPO
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- genomics-online: gRNA clones - Search results for 87 available LPO gene related products
- Overview of 87 available LPO gene related products
- Applied Biological Materials CRISPR for LPO
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPO
- GenScript: Design CRISPR guide RNA sequences for LPO
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPO
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- genomics-online: shRNA clones - Search results for 87 available LPO gene related products
- Overview of 87 available LPO gene related products
Clone Products
- Sino Biological Human cDNA Clone for LPO
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPO
- Applied Biological Materials Clones for LPO
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LPO
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LPO Gene
Localization for LPO Gene
Subcellular locations from UniProtKB/Swiss-Prot for LPO Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 3 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 24248522 |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0016323 | basolateral plasma membrane | IDA | 19059195 |
| GO:0070062 | extracellular exosome | HDA | 19199708 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPO Gene
Pathways & Interactions for LPO Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Salivary secretion | ||
Pathways by source for LPO Gene
1 KEGG pathway for LPO Gene
Interacting Proteins for LPO Gene
GPS-Prot Interaction Network for LPO
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste | IDA | 24248522 |
| GO:0006979 | response to oxidative stress | NAS | 8964511 |
| GO:0018969 | thiocyanate metabolic process | IEA | -- |
| GO:0042742 | defense response to bacterium | IDA | 12626341 |
| GO:0042744 | hydrogen peroxide catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for LPO Gene
Drugs & Compounds for LPO Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 | ||||
| Hypothiocyanite |
|
63296-34-4 | ||||
| 2-Phenylacetamide |
|
103-81-1 |
|
|||
| methanol |
|
67-56-1 |
|
Drug Products
Transcripts for LPO Gene
mRNA/cDNA for LPO Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000582328 2680 bps (uc060hxc.1)
- ENST00000262290 2979 bps (uc002ivt.3)
- ENST00000543544 2350 bps (uc010wns.3)
- ENST00000578403 1483 bps (uc060hxd.1)
- ENST00000582684 582 bps (uc060hxe.1)
Unigene Clusters for LPO Gene
- Lactoperoxidase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for LPO
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for LPO
- genomics-online: gRNA clones - Search results for 87 available LPO gene related products
- Overview of 87 available LPO gene related products
- Applied Biological Materials CRISPR for LPO
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LPO
- GenScript: Design CRISPR guide RNA sequences for LPO
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LPO
- Browse OriGene Inhibitory RNA Products For LPO
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPO
- genomics-online: shRNA clones - Search results for 87 available LPO gene related products
- Overview of 87 available LPO gene related products
Clone Products
- Sino Biological Human cDNA Clone for LPO
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for LPO
- Applied Biological Materials Clones for LPO
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Expression for LPO Gene
mRNA differential expression in normal tissues according to GTEx for LPO Gene
This gene is overexpressed in Minor Salivary Gland (x42.0).
This gene is overexpressed in Salivary gland (36.7), Saliva (20.3), and Skin (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPO Gene
NURSA nuclear receptor signaling pathways regulating expression of LPO Gene:
LPOSOURCE GeneReport for Unigene cluster for LPO Gene:
Hs.234742mRNA Expression by UniProt/SwissProt for LPO Gene:
P22079-PERL_HUMAN
Tissue specificity:
Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.
Evidence on tissue expression from TISSUES for LPO Gene
- Saliva(4.6)
- Blood(2.3)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for LPO
-
OriGene qPCR primer pairs and template standards for LPO
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPO Gene
Orthologs for LPO Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LPO 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LPO 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | LPO 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Lpo 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Lpo 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | LPO 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | LPO 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | mpx 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG10211 35 |
|
|
|
| CG6879 35 |
|
|
|||
| Pxd 35 |
|
|
|||
| CG6969 35 |
|
|
|||
| pxt 35 |
|
|
|||
| CG5873 34 35 |
|
ManyToMany | |||
| CG8913 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | ZK430.8 35 |
|
|
|
| K10B4.1 35 |
|
|
|||
| C46A5.4 35 |
|
|
|||
| F09F3.5 35 |
|
|
|||
| R08F11.7 34 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for LPO was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for LPO Gene
- ENSEMBL:
- Gene Tree for LPO (if available)
- TreeFam:
- Gene Tree for LPO (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for LPO: view image
Paralogs for LPO Gene
Variants for LPO Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs67390833 | benign, not specified | 58,244,091(+) | ACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACAC/ACACACACACACACACACACACACACACACACACACACACACACAC | genic_upstream_transcript_variant, intron_variant | |
| rs1000156234 | -- | 58,238,663(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant | |
| rs1000159089 | -- | 58,268,652(+) | A/G | downstream_transcript_variant | |
| rs1000306544 | -- | 58,254,412(+) | T/C | intron_variant | |
| rs1000358578 | -- | 58,254,121(+) | AGA/AGAAAGA | intron_variant |
Residual Variation Intolerance Score:
21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.45;
77.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LPO Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LPO
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPO Gene
Disorders for LPO Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dental caries |
|
|
| aplasia of lacrimal and salivary glands |
|
|
| cystic fibrosis |
|
|
| asthma |
|
|
| common cold |
|
|
Search LPO in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LPO
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LPO Gene
Publications for LPO Gene
- Molecular cloning of cDNAs encoding bovine and human lactoperoxidase. (PMID: 2222811) Dull TJ … Seilhamer JJ (DNA and cell biology 1990) 2 3 4 22 58
- Molecular heterogeneity and alternative splicing of human lactoperoxidase. (PMID: 19059195) Fragoso MA … Conner GE (Archives of biochemistry and biophysics 2009) 3 4 22 58
- Lactoperoxidase and human airway host defense. (PMID: 12626341) Wijkstrom-Frei C … Conner GE (American journal of respiratory cell and molecular biology 2003) 3 4 22 58
- Identification of lactoperoxidase in mature human milk. (PMID: 10715594) Shin K … Lönnerdal B (The Journal of nutritional biochemistry 2000) 3 4 22 58
- Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA. (PMID: 8964511) Kiser C … Rahemtulla F (Gene 1996) 2 3 4 58
Products for LPO Gene
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- Taconic Biosciences Mouse Models for LPO
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
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- Overview of 87 available LPO gene related products
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Sources for LPO Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
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