Aliases for LPIN3 Gene
External Ids for LPIN3 Gene
Previous HGNC Symbols for LPIN3 Gene
Previous GeneCards Identifiers for LPIN3 Gene
The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for LPIN3 Gene
LPIN3 (Lipin 3) is a Protein Coding gene. Diseases associated with LPIN3 include Nemaline Myopathy 1 and Peroneal Neuropathy. Among its related pathways are Cell Cycle, Mitotic and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and phosphatidate phosphatase activity. An important paralog of this gene is LPIN2.
UniProtKB/Swiss-Prot Summary for LPIN3 Gene
Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism.