Aliases for LPIN2 Gene
External Ids for LPIN2 Gene
Previous GeneCards Identifiers for LPIN2 Gene
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
GeneCards Summary for LPIN2 Gene
LPIN2 (Lipin 2) is a Protein Coding gene. Diseases associated with LPIN2 include Majeed Syndrome and Chronic Recurrent Multifocal Osteomyelitis. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and phosphatidate phosphatase activity. An important paralog of this gene is LPIN1.
UniProtKB/Swiss-Prot Summary for LPIN2 Gene
Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).