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This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
LPGAT1 (Lysophosphatidylglycerol Acyltransferase 1) is a Protein Coding gene. Diseases associated with LPGAT1 include Progressive Familial Heart Block, Type Ii and Cardiomyopathy, Dilated, 1D. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is LCLAT1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016746 | transferase activity, transferring acyl groups | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 10942595 |
GO:0005783 | endoplasmic reticulum | IBA | 21873635 |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0012505 | endomembrane system | IBA | 21873635 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
SuperPathway | Contained pathways | ||
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1 | Glycerophospholipid biosynthesis | ||
2 | Metabolism |
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Symbol | External ID(s) | Details |
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CLN3 | ||
ENSG00000272822 | ||
HSPA1L | ||
HSPA8 | ||
IZUMO1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0008654 | phospholipid biosynthetic process | IEA | -- |
GO:0036148 | phosphatidylglycerol acyl-chain remodeling | TAS | -- |
GO:0036149 | phosphatidylinositol acyl-chain remodeling | IBA | 21873635 |
GO:0045723 | positive regulation of fatty acid biosynthetic process | IMP | 23749231 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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LysoPA(0:0/16:0) |
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LysoPA(0:0/18:0) |
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LysoPA(0:0/18:1(9Z)) |
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LysoPA(0:0/18:2(9Z,12Z)) |
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LysoPA(16:0/0:0) |
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ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
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SP1: | |||||||||||||||||
SP2: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LPGAT1 30 31 |
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OneToOne | |
Dog (Canis familiaris) |
Mammalia | LPGAT1 30 31 |
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OneToOne | |
Cow (Bos Taurus) |
Mammalia | LPGAT1 30 31 |
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OneToOne | |
Mouse (Mus musculus) |
Mammalia | Lpgat1 30 17 31 |
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OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Lpgat1 30 |
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Oppossum (Monodelphis domestica) |
Mammalia | LPGAT1 31 |
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OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | LPGAT1 31 |
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OneToOne | |
Chicken (Gallus gallus) |
Aves | LPGAT1 30 31 |
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OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | LPGAT1 31 |
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OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | MGC68966 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | lpgat1 30 31 |
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OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002482 30 |
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Worm (Caenorhabditis elegans) |
Secernentea | acl-14 30 31 |
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OneToMany | |
acl-12 31 |
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OneToMany | |||
acl-13 31 |
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OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
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783964 | Benign: not provided | 211,751,077(-) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2665423 | CNV | deletion | 23128226 |
esv2722406 | CNV | deletion | 23290073 |
esv3418118 | CNV | insertion | 20981092 |
esv3440536 | CNV | insertion | 20981092 |
esv3546055 | CNV | deletion | 23714750 |
esv3588735 | CNV | gain | 21293372 |
esv3588737 | CNV | loss | 21293372 |
esv3588738 | CNV | loss | 21293372 |
nsv1068853 | CNV | deletion | 25765185 |
nsv1137844 | CNV | deletion | 24896259 |
nsv826553 | CNV | loss | 20364138 |
Disorder | Aliases | PubMed IDs |
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progressive familial heart block, type ii |
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cardiomyopathy, dilated, 1d |
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progressive familial heart block |
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