This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] See more...

Aliases for LPGAT1 Gene

Aliases for LPGAT1 Gene

  • Lysophosphatidylglycerol Acyltransferase 1 2 3 5
  • Acyl-CoA:Lysophosphatidylglycerol Acyltransferase 1 3 4
  • Family With Sequence Similarity 34, Member A 2 3
  • KIAA0205 2 4
  • FAM34A1 2 3
  • FAM34A 3 4
  • NET8 2 3
  • EC 2.3.1.- 4
  • LPGAT1 5

External Ids for LPGAT1 Gene

Previous HGNC Symbols for LPGAT1 Gene

  • FAM34A

Previous GeneCards Identifiers for LPGAT1 Gene

  • GC01M208307
  • GC01M209983
  • GC01M211916
  • GC01M182594

Summaries for LPGAT1 Gene

Entrez Gene Summary for LPGAT1 Gene

  • This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for LPGAT1 Gene

LPGAT1 (Lysophosphatidylglycerol Acyltransferase 1) is a Protein Coding gene. Diseases associated with LPGAT1 include Progressive Familial Heart Block, Type Ii and Cardiomyopathy, Dilated, 1D. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is LCLAT1.

UniProtKB/Swiss-Prot Summary for LPGAT1 Gene

  • Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.

Additional gene information for LPGAT1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for LPGAT1 Gene

Genomics for LPGAT1 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around LPGAT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for LPGAT1

Top Transcription factor binding sites by QIAGEN in the LPGAT1 gene promoter:
  • AML1a
  • ATF6
  • FOXO1
  • FOXO1a
  • Hlf
  • HOXA3
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for LPGAT1 Gene

Genomic Locations for LPGAT1 Gene
chr1:211,743,457-211,830,763
(GRCh38/hg38)
Size:
87,307 bases
Orientation:
Minus strand
chr1:211,916,799-212,004,114
(GRCh37/hg19)
Size:
87,316 bases
Orientation:
Minus strand

Genomic View for LPGAT1 Gene

Genes around LPGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPGAT1 Gene

Proteins for LPGAT1 Gene

  • Protein details for LPGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92604-LGAT1_HUMAN
    Recommended name:
    Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
    Protein Accession:
    Q92604
    Secondary Accessions:
    • Q53YL2

    Protein attributes for LPGAT1 Gene

    Size:
    370 amino acids
    Molecular mass:
    43089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13196.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LPGAT1 Gene

Post-translational modifications for LPGAT1 Gene

  • Ubiquitination at Lys201
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LPGAT1 Gene

Domains & Families for LPGAT1 Gene

Gene Families for LPGAT1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LPGAT1 Gene

InterPro:
Blocks:
  • Phospholipid/glycerol acyltransferase
ProtoNet:

Suggested Antigen Peptide Sequences for LPGAT1 Gene

GenScript: Design optimal peptide antigens:
  • Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LGAT1_HUMAN)
  • Lysophosphatidylglycerol acyltransferase 1, isoform CRA_a (Q53YL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92604

UniProtKB/Swiss-Prot:

LGAT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPGAT1: view

Function for LPGAT1 Gene

Molecular function for LPGAT1 Gene

UniProtKB/Swiss-Prot Function:
Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.

Enzyme Numbers (IUBMB) for LPGAT1 Gene

Phenotypes From GWAS Catalog for LPGAT1 Gene

Gene Ontology (GO) - Molecular Function for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IBA 21873635
genes like me logo Genes that share ontologies with LPGAT1: view
genes like me logo Genes that share phenotypes with LPGAT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPGAT1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPGAT1 Gene

Localization for LPGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPGAT1 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPGAT1 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 3
plasma membrane 2
mitochondrion 2
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1
lysosome 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0012505 endomembrane system IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with LPGAT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPGAT1 Gene

Pathways & Interactions for LPGAT1 Gene

genes like me logo Genes that share pathways with LPGAT1: view

Pathways by source for LPGAT1 Gene

Gene Ontology (GO) - Biological Process for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036148 phosphatidylglycerol acyl-chain remodeling TAS --
GO:0036149 phosphatidylinositol acyl-chain remodeling IBA 21873635
GO:0045723 positive regulation of fatty acid biosynthetic process IMP 23749231
genes like me logo Genes that share ontologies with LPGAT1: view

No data available for SIGNOR curated interactions for LPGAT1 Gene

Drugs & Compounds for LPGAT1 Gene

(131) Additional Compounds for LPGAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPA(0:0/16:0)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic Acid(0:0/18:0)
  • Lysophosphatidic Acid(18:0)
  • 2-stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic Acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic Acid(0:0/18:1)
  • 2-oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic Acid(18:2)
LysoPA(16:0/0:0)
  • 1-Hexadecanoyl-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-sn-glycero-3-phosphoric acid
  • 1-Palmitoylglycerol 3-phosphoric acid
  • 1-Palmitoyl-sn-glycerol 3-phosphate
  • PLPA
genes like me logo Genes that share compounds with LPGAT1: view

Transcripts for LPGAT1 Gene

mRNA/cDNA for LPGAT1 Gene

6 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LPGAT1

Alternative Splicing Database (ASD) splice patterns (SP) for LPGAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for LPGAT1 Gene

GeneLoc Exon Structure for
LPGAT1

Expression for LPGAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPGAT1 Gene

This gene is overexpressed in Fetal gut (18.3), Islet of Langerhans (10.4), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LPGAT1 Gene



Protein tissue co-expression partners for LPGAT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for LPGAT1

SOURCE GeneReport for Unigene cluster for LPGAT1 Gene:

Hs.744851

mRNA Expression by UniProt/SwissProt for LPGAT1 Gene:

Q92604-LGAT1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.

Evidence on tissue expression from TISSUES for LPGAT1 Gene

  • Liver(4.5)
  • Bone marrow(4.2)
  • Nervous system(3.9)
  • Blood(2.3)
  • Heart(2.2)
  • Kidney(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with LPGAT1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPGAT1 Gene

Orthologs for LPGAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LPGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LPGAT1 30 31
  • 99.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LPGAT1 30 31
  • 93.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LPGAT1 30 31
  • 92.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Lpgat1 30 17 31
  • 89.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Lpgat1 30
  • 89.28 (n)
Oppossum
(Monodelphis domestica)
Mammalia LPGAT1 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia LPGAT1 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LPGAT1 30 31
  • 79.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia LPGAT1 31
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68966 30
Zebrafish
(Danio rerio)
Actinopterygii lpgat1 30 31
  • 66.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002482 30
  • 52.14 (n)
Worm
(Caenorhabditis elegans)
Secernentea acl-14 30 31
  • 49.13 (n)
OneToMany
acl-12 31
  • 25 (a)
OneToMany
acl-13 31
  • 23 (a)
OneToMany
Species where no ortholog for LPGAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for LPGAT1 Gene

ENSEMBL:
Gene Tree for LPGAT1 (if available)
TreeFam:
Gene Tree for LPGAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LPGAT1: view image

Paralogs for LPGAT1 Gene

Paralogs for LPGAT1 Gene

Pseudogenes.org Pseudogenes for LPGAT1 Gene

genes like me logo Genes that share paralogs with LPGAT1: view

Variants for LPGAT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for LPGAT1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
783964 Benign: not provided 211,751,077(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for LPGAT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LPGAT1 Gene

Variant ID Type Subtype PubMed ID
esv2665423 CNV deletion 23128226
esv2722406 CNV deletion 23290073
esv3418118 CNV insertion 20981092
esv3440536 CNV insertion 20981092
esv3546055 CNV deletion 23714750
esv3588735 CNV gain 21293372
esv3588737 CNV loss 21293372
esv3588738 CNV loss 21293372
nsv1068853 CNV deletion 25765185
nsv1137844 CNV deletion 24896259
nsv826553 CNV loss 20364138

Variation tolerance for LPGAT1 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LPGAT1 Gene

Human Gene Mutation Database (HGMD)
LPGAT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPGAT1 Gene

Disorders for LPGAT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LPGAT1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LPGAT1

genes like me logo Genes that share disorders with LPGAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPGAT1 Gene

Publications for LPGAT1 Gene

  1. Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase. (PMID: 15485873) Yang Y … Shi Y (The Journal of biological chemistry 2004) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for LPGAT1 Gene

Sources for LPGAT1 Gene